PE-22-28 (8mg) – Premium Research Peptide for Neuroscience Studies

Welcome to Liaocheng Yixin Company, your trusted source for premium pe-22-28 8mg for research. As a specialized peptide synthesis manufacturer operating from our facility at No. 9 Lushan Road, Dongcheng Street, Liaocheng Economic and Technological Development Zone, Shandong Province, we provide high-quality research compounds for the global scientific community.

PE-22-28 is a synthetic seven-amino-acid peptide derived from a larger naturally occurring peptide called spadin, which is itself processed from the sortilin protein . This peptide functions as a potent and selective inhibitor of the TREK-1 potassium channel, a key regulator of neuronal excitability . Our pe-22-28 8mg for research offers investigators a reliable, high-purity compound for neuroscience, neuroplasticity, and antidepressant research.

What is PE-22-28?

PE-22-28 (CAS: 1801959-12-5) is a shortened analog of spadin (PE 12-28), designed to improve in vivo stability and bioavailability . It is a 7-amino-acid peptide with the sequence GVSWGLR (Gly-Val-Ser-Trp-Gly-Leu-Arg) .

Key identifiers:

• CAS Number: 1801959-12-5 

• Molecular Formula: C35H55N11O9 

• Molecular Weight: 773.89 Da 

• Sequence: GVSWGLR (Gly-Val-Ser-Trp-Gly-Leu-Arg) 

• Parent Compound: Spadin (17-mer from sortilin propeptide) 

• Target: TREK-1 (KCNK2) potassium channel 

• Purity: ≥99% verified by HPLC

Mechanism of Action in Research

PE-22-28 exerts its effects through selective inhibition of the TREK-1 (TWIK-related potassium channel-1) channel :

TREK-1 Channel Inhibition

PE-22-28 displays exceptional potency as a TREK-1 channel inhibitor. In vitro patch-clamp studies on hTREK-1/HEK cells demonstrated that PE-22-28 has an IC50 of 0.12 nM, compared to 40–60 nM for spadin . This represents a significantly improved specificity and affinity .

TREK-1 channels are two-pore domain potassium channels that play a pivotal role in stabilizing membrane potential and preventing cellular excitability . They are involved in various physiological processes, including pain, epilepsy, stroke, and depression .

Neuronal Excitability Modulation

PE-22-28 increases neuronal excitability, which is thought to support antidepressant-like effects. Research has demonstrated that PE-22-28 promotes neurogenesis and synaptogenesis through modulation of the serotonergic neurotransmission system .

Scientific Research Applications

PE-22-28 has been extensively studied across multiple research domains:

Antidepressant Research

PE-22-28 is primarily investigated for its rapid antidepressant-like effects in research models :

• Forced Swimming Test (FST): Mice treated with PE-22-28 showed a significant reduction in immobility time, indicating antidepressant-like activity .

• Novelty Suppressed Feeding Test (NSFT): After a 4-day sub-chronic treatment, PE-22-28 significantly reduced the latency to eat the food pellet .

• Fast Onset: PE-22-28 demonstrates antidepressant-like effects within 4 days of treatment, compared to 3-4 weeks for classical antidepressants like SSRIs .

Neurogenesis Research

PE-22-28 was shown to induce neurogenesis after only a 4-day treatment, with a prominent effect observed in its G/A-PE 22-28 derivative .

Synaptogenesis Research

On mouse cortical neurons, PE-22-28 and its derivatives enhanced synaptogenesis, measured by an increase in PSD-95 expression levels .

Action Duration Studies

The action duration of PE-22-28 was significantly improved compared to spadin, lasting up to 23 hours instead of 7 hours . This makes PE-22-28 a valuable research tool for studying sustained TREK-1 inhibition.

Why Choose Liaocheng Yixin Company?

When sourcing pe-22-28 8mg for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• Appearance: White lyophilized powder

• Solubility: Water soluble up to 2 mg/mL 

• Storage: Store powder at -20°C in a sealed container, protected from light and moisture 

• Form: Lyophilized powder for research use

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. Packaged in sterile conditions for research use

When you need premium pe-22-28 8mg for research for your neuroscience, antidepressant, or neuroplasticity studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.