CJC-1295 DAC (5mg) – Premium Sustained-Release GHRH Analog for Research

Welcome to Liaocheng Yixin Company, your trusted source for premium cjc-1295 dac 5mg for research. As a specialized peptide synthesis manufacturer operating from our facility at No. 9 Lushan Road, Dongcheng Street, Liaocheng Economic and Technological Development Zone, Shandong Province, we provide high-quality research compounds for the global scientific community.

CJC-1295 DAC is a synthetic peptide analogue of growth hormone-releasing hormone (GHRH) that incorporates a Drug Affinity Complex (DAC) moiety designed to dramatically extend the compound’s half-life by binding to serum albumin . Unlike non-DAC GHRH analogs that produce brief, pulsatile GH pulses, CJC-1295 DAC is engineered for sustained signaling, maintaining elevated plasma growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels for extended periods . Our cjc-1295 dac 5mg for research offers investigators a reliable, high-purity compound for studying sustained GH exposure, receptor downregulation, and pharmacokinetic profiling.

What is CJC-1295 DAC?

CJC-1295 DAC is a modified form of growth hormone-releasing hormone that facilitates the prolonged release of growth hormone from the anterior pituitary . The DAC modification consists of a maleimidoproprionic acid (MPA) moiety that forms a covalent bond with serum albumin, protecting the peptide from enzymatic degradation and renal clearance .

Key identifiers:

• CAS Number: 863288-34-0 (free base) 

• Molecular Formula: C154H256N44O44 

• Molecular Weight: 3428.01 g/mol 

• Synonyms: DAC:GRF, CJC-1295 with DAC, CJC-1295 Drug Affinity Complex

• Sequence: H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2 

• Purity: ≥99% verified by HPLC

Mechanism of Action in Research

CJC-1295 DAC functions through a mechanism that distinguishes it from short-acting GHRH analogs, with implications for pituitary receptor biology.

Extended Plasma Half-Life

The DAC modification extends the plasma half-life of CJC-1295 from minutes to approximately 7-8 days . Teichman et al. (2006) reported that a single subcutaneous injection results in drug concentrations measurable for 10 to 13 days after administration, with a half-life of up to 8 days . This sustained presence in circulation allows for continuous GHRH receptor engagement.

GHRH Receptor Agonism

CJC-1295 DAC binds to the GHRH receptor (GHRHR) on anterior pituitary somatotrophs, activating Gs-coupled adenylyl cyclase signaling. With a single injection, CJC-1295 increases plasma GH levels by 2- to 10-fold for 6 days or longer, and plasma IGF-1 levels by 0.5- to 3-fold for 9 to 11 days . With multiple doses, IGF-1 levels can remain elevated for up to 28 days .

Sustained vs. Pulsatile GH Release

Unlike short-acting GHRH analogs such as Mod GRF 1-29 (CJC-1295 No DAC), which produce brief 30-minute pulses that mimic natural GH rhythm, CJC-1295 DAC creates sustained GH elevation . This distinction is critical in research design: pulsatile GH exposure is considered more physiologic and may have different downstream effects than continuous GH elevation.

Receptor Desensitization Concerns

The sustained activation profile of CJC-1295 DAC raises important questions for receptor biology. FDA documentation notes that the loss of GH secretagogue activity in the presence of sustained CJC-1295 DAC levels could be due to: (1) CJC-1295 DAC-induced down-regulation of GHRH receptors in the anterior pituitary gland; (2) a decline in pituitary GH content; and/or (3) activation of a negative feedback loop regulated by somatostatin and IGF-1 .cjc-1295 dac 5mg for research

Scientific Research Applications

CJC-1295 DAC has been studied across multiple research domains:

Growth Hormone Axis Research

CJC-1295 DAC is used to investigate sustained GH and IGF-1 elevation mechanisms, pituitary receptor regulation, and the feedback loops governing GH secretion.

Visceral Obesity and Metabolic Research

A Phase 2 clinical trial (NCT00267527) evaluated CJC-1295 in HIV patients with visceral obesity . This application stemmed from the premise that increased GH levels promote lipolysis, making sustained GH elevation a potential research tool for fat metabolism studies .

Receptor Pharmacodynamics

The sustained receptor engagement profile of CJC-1295 DAC makes it valuable for studying receptor downregulation, desensitization, and recovery kinetics. FDA documentation notes that Jette et al. (2005) suggested the DAC modification accounts for the peptide’s greater stability and longer half-life compared to native GHRH 1-29 .

Comparative GHRH Analog Studies

Researchers use CJC-1295 DAC alongside no-DAC versions (Mod GRF 1-29) to compare sustained versus pulsatile GH exposure kinetics, assessing how the pattern of receptor activation influences downstream biology.

Combination Research

Some research protocols combine CJC-1295 DAC with GHRPs such as GHRP-6 or Ipamorelin. Studies suggest that combining a GHRP with CJC-1295 DAC significantly increases GH and IGF-1 production . The GHRP-6 suppresses somatostatin to “make way” for the GHRH pulse, creating a permissive environment for GH release .

Why Choose Liaocheng Yixin Company?

When sourcing cjc-1295 dac 5mg for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. Our CJC-1295 DAC meets ≥99% purity standards. Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• Molecular Weight: 3428.01 g/mol 

• Appearance: White lyophilized powder 

• Storage: Powder at -20°C for up to 3 years; 4°C for up to 2 years; in solvent at -80°C for up to 6 months 

• Form: Lyophilized powder for research use

• cjc-1295 dac 5mg for research

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis 

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. Packaged in sterile conditions for research use

6. cjc-1295 dac 5mg for research

: What is the distinction between CJC-1295 DAC and CJC-1295 No DAC in research?

A: CJC-1295 DAC incorporates a Drug Affinity Complex that binds to albumin, extending its half-life to approximately 7-8 days and producing sustained GH elevation . CJC-1295 No DAC (also known as Modified GRF 1-29 or Mod GRF 1-29) has no DAC, a half-life of approximately 30 minutes, and produces brief, pulsatile GH release that mimics natural secretory patterns . This distinction is critical in research design: sustained vs. pulsatile exposure may have different effects on receptor regulation and downstream biology.

: What research applications use CJC-1295 DAC?

A: CJC-1295 DAC is used in growth hormone axis research, visceral obesity and metabolic studies, receptor pharmacodynamics, comparative GHRH analog studies, and combination research with GHRPs.

: What are the key pharmacokinetic properties of CJC-1295 DAC?

A: With a single injection in human subjects, CJC-1295 DAC increases plasma GH levels by 2- to 10-fold for 6 days or longer, and plasma IGF-1 levels by 0.5- to 3-fold for 9 to 11 days . The drug has an estimated half-life of about 6 to 8 days in humans .cjc-1295 dac 5mg for research

: What is the rationale for combining CJC-1295 DAC with GHRPs?

A: GHRPs such as GHRP-6 suppress somatostatin (growth hormone-inhibiting hormone), creating a permissive environment for the GHRH pulse from CJC-1295 DAC . Studies suggest that combining a GHRP with CJC-1295 DAC significantly increases GH and IGF-1 production without increasing prolactin .

: What purity level can I expect?

A: All batches are tested to ensure ≥99% purity by HPLC analysis. Certificates of Analysis are available upon request.

: Is this product for human use?

A: No. Our CJC-1295 DAC is manufactured strictly for research use only (RUO). It is not intended for human consumption or clinical applications .

When you need premium cjc-1295 dac 5mg for research for your sustained GH exposure, receptor pharmacodynamics, or metabolic studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust. cjc-1295 dac 5mg for research