Buy Acetyl Hexapeptide-3 (Argireline) – Premium Research Grade Anti-Wrinkle Peptide

 

Welcome to Liaocheng Yixin Company, your trusted source to buy acetyl hexapeptide-3 argireline for research. As a licensed peptide synthesis manufacturer operating from our facility in Shandong Province, China, we provide high-quality research compounds for the global scientific community.

Acetyl hexapeptide-3 (Argireline®) is a synthetic peptide with the sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂ . It is a fragment of the SNAP-25 protein, a key component of the SNARE complex responsible for neurotransmitter release at the neuromuscular junction . When you buy acetyl hexapeptide-3 argireline for research, you gain access to a well-characterized peptide for investigating neuromodulation, anti-aging mechanisms, and cellular signaling pathways.  buy acetyl hexapeptide-3 argireline for research

What is Acetyl Hexapeptide-3 (Argireline)?

Acetyl hexapeptide-3 is a six-amino-acid peptide that mimics the N-terminal end of the SNAP-25 protein . It functions as a competitive inhibitor of the SNARE complex, which is essential for the fusion of synaptic vesicles with the presynaptic membrane during neurotransmitter exocytosis . buy acetyl hexapeptide-3 argireline for research

Key identifiers:

• CAS Number: 616204-22-9 

• Molecular Formula: C₃₄H₆₀N₁₄O₁₂S 

• Molecular Weight: 888.99 g/mol 

• Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂ (Ac-EEMQRR-NH₂) 

• Synonyms: Argireline, Acetyl hexapeptide-8

• Purity: ≥99% verified by HPLC

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Mechanism of Action in Research

Argireline operates through a well-characterized mechanism that makes it a valuable research tool .

SNARE Complex Inhibition

Argireline competes with SNAP-25 for a position in the SNARE complex . The SNARE complex, composed of syntaxin, SNAP-25, and synaptobrevin (VAMP), is the central machinery responsible for the fusion of synaptic vesicles with the presynaptic membrane .

By disrupting the SNARE complex, argireline destabilizes vesicle fusion, leading to a reduction in the release of neurotransmitters like acetylcholine at the neuromuscular junction . This results in attenuated muscle contraction, which is the basis for its anti-wrinkle activity .  buy acetyl hexapeptide-3 argireline for research

In Vitro Activity

In permeabilized chromaffin cells, argireline has been shown to inhibit calcium-dependent catecholamine release . In HEK-293 cells, it exhibits a dose-dependent antiproliferative effect with an IC₅₀ of 34.862 μM . buy acetyl hexapeptide-3 argireline for research

In Vivo Activity

In aged mice treated topically twice daily for six weeks, argireline demonstrated histological improvements in skin tissue, including increased type I collagen fibers and decreased type III collagen fibers .

Scientific Research Applications

Argireline has been studied across multiple research domains:

Anti-Wrinkle Research

Clinical studies have demonstrated argireline’s efficacy in reducing wrinkle depth. In a 30-day study using a 10% solution, subjects showed up to a 30% reduction in wrinkle depth . A randomized, placebo-controlled trial in Chinese subjects demonstrated a 48.9% total anti-wrinkle efficacy .

Skin Penetration and Delivery Research

Argireline’s large molecular size and hydrophilic character limit its diffusion through the lipophilic stratum corneum . Research has explored liposomal formulations to enhance skin permeation, with studies showing that 96.7% of the active can be encapsulated into liposomes . buy acetyl hexapeptide-3 argireline for research

Cellular Signaling Studies

Argireline has been studied for its effects on cell viability in various cell lines, including HEK-293 (IC₅₀ of 34.862 μM) and neuroblastoma IMR-32 cells (IC₅₀ of 68.458 μM) .

Why Choose Liaocheng Yixin Company?

When you buy acetyl hexapeptide-3 argireline for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. Our Argireline meets ≥99% purity standards. Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• Sequence: Ac-EEMQRR-NH₂

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• Molecular Weight: 888.99 g/mol

• Appearance: White lyophilized powder

• Storage: Store powder at -20°C in a sealed, desiccated container, protected from light and moisture 

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification (>99%)

4. Mass Spectrometry for molecular weight confirmation

5. Packaged under sterile conditions for research use

6.  buy acetyl hexapeptide-3 argireline for researchork in research?

: What is Argireline and how does it 

A: Argireline (Acetyl hexapeptide-3) is a synthetic peptide that mimics the N-terminal end of SNAP-25 and competitively inhibits the SNARE complex, reducing neurotransmitter release and muscle contraction .

: What are the key research applications for Argireline?

A: Argireline is used in anti-wrinkle research, skin penetration and delivery studies, and cellular signaling research.

: What is the IC₅₀ of Argireline in cell lines?

A: In HEK-293 cells, the IC₅₀ is 34.862 μM; in neuroblastoma IMR-32 cells, the IC₅₀ is 68.458 μM .

: What purity level can I expect?

A: All batches are tested to ensure ≥99% purity by HPLC analysis. Certificates of Analysis are available upon request.

: Is this product for human use?

A: No. Our Argireline is manufactured strictly for research use only (RUO). It is not intended for human consumption or clinical applications.

When you need to buy acetyl hexapeptide-3 argireline for research for your neuromodulation, anti-aging, or cellular signaling studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.  buy acetyl hexapeptide-3 argireline for research