PTD-DBM (5mg) – Premium Research Peptide for Wnt/CXXC5 Studies

Welcome to Liaocheng Yixin Company, your trusted source for premium ptd-dbm 5mg for research. As a specialized peptide synthesis manufacturer operating from our facility at No. 9 Lushan Road, Dongcheng Street, Liaocheng Economic and Technological Development Zone, Shandong Province, we provide high-quality research compounds for the global scientific community.

PTD-DBM is a synthetic peptide designed to target a specific protein-protein interaction involved in hair follicle cycling and wound healing. It represents a mechanistically novel tool for investigating the Wnt/β-catenin signaling pathway, a fundamental regulator of stem cell biology and tissue regeneration. Our ptd-dbm 5mg for research offers investigators a reliable, high-purity peptide for preclinical studies in regenerative biology and dermatology research.

What is PTD-DBM?

PTD-DBM, whose CAS number is 1609454-11-6, is a synthetic peptide that acts as a competitive inhibitor of the CXXC5-Dishevelled (Dvl) interaction . The structure is comprised of a Protein Transduction Domain (PTD), a flexible linker, a Dishevelled Binding Motif (DBM), and often a fluorescent tag for visualization . This domain structure allows the peptide to cross cellular membranes independently, making it a practical tool for studies without the need for transfection reagents .

Key identifiers:

• CAS Number: 1609454-11-6

• Molecular Formula: C₁₂₄H₂₂₅N₆₁O₂₈S₂ 

• Molecular Weight: ~3082.62 g/mol 

• Sequence: RRRRRRRRRGGGRKGTGHQICKFRKC 

• Purity: ≥99% verified by HPLC

• Form: Lyophilized powder for research use

Mechanism of Action in Research

The Wnt/β-Catenin Signaling Pathway

PTD-DBM is designed to modulate the Wnt/β-catenin signaling cascade, a critical pathway that governs hair follicle cycling, wound healing, and tissue regeneration . In the context of hair follicle biology, Wnt signaling promotes the transition from resting to growth phases. The activity of this pathway is negatively regulated by the protein CXXC5, which acts as a molecular brake .

CXXC5-Dishevelled Interaction

PTD-DBM functions by competitively binding to Dishevelled (Dvl), a key mediator in the Wnt pathway, effectively blocking the CXXC5-Dvl interaction . By disrupting this interaction, PTD-DBM prevents CXXC5 from inhibiting the pathway, thereby restoring Wnt/β-catenin signaling .

Intracellular Delivery by PTD Domain

A crucial structural feature of PTD-DBM is the Protein Transduction Domain (PTD), which allows the peptide to penetrate the cell membrane and reach its intracellular target . This delivery system is integral to the peptide’s function, enabling its effect without the need for auxiliary delivery methods.

Scientific Research Applications

PTD-DBM is primarily a tool for preclinical research, specifically investigating the molecular mechanisms of regeneration .

Cutaneous Wound Healing Research

One of the key areas of study is cutaneous wound healing. Research on human dermal fibroblasts has shown that PTD-DBM induces the expression of key proteins involved in tissue repair, such as β-catenin, α-SMA, and type I collagen . In vivo studies on mice have demonstrated that topical application of PTD-DBM accelerates wound closure and promotes collagen synthesis, indicating a potential role in scarless wound healing .

Hair Follicle Research

PTD-DBM is also being investigated for its potential to stimulate hair follicle regeneration. In animal models of androgenetic alopecia (DHT-induced hair loss), PTD-DBM treatment has been shown to reactivate Wnt/β-catenin signaling in dermal papilla cells, restoring hair growth . The peptide appears to achieve this by reversing the suppression of Wnt signaling, a key molecular feature of balding scalp .

Cell Signaling Studies

For researchers studying the Wnt/β-catenin pathway, PTD-DBM serves as a specific tool for disrupting a defined protein-protein interaction. Its ability to directly inhibit the CXXC5-Dvl complex allows for precise investigation of the pathway’s role in cell proliferation, differentiation, and stem cell maintenance .

Why Choose Liaocheng Yixin Company?

When sourcing ptd-dbm 5mg for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• Appearance: White lyophilized powder

• Storage: Store powder at -20°C in a sealed container, protected from light and moisture

• Form: Lyophilized powder for research use

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. Packaged in sterile conditions for research use

When you need premium ptd-dbm 5mg for research for your regenerative biology, wound healing, or Wnt signaling studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.