Receptor Grade IGF-1 LR3 (100mcg) – Premium Research Peptide for Cell Culture & Regenerative Studies

Welcome to Liaocheng Yixin Company, your trusted source for premium receptor grade igf-1 lr3 100mcg. As a specialized peptide synthesis manufacturer operating from our facility in Shandong Province, China, we provide high-quality research compounds for the global scientific community.

Receptor Grade IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a synthetic analog of the naturally occurring IGF-1 protein, specifically engineered for enhanced potency in research applications . Our receptor grade igf-1 lr3 100mcg offers investigators a reliable, high-purity compound for cell culture studies, growth factor signaling research, and tissue engineering applications.

What is Receptor Grade IGF-1 LR3?

Insulin-like Growth Factor-1 (IGF-1) is a naturally produced protein with 70 amino acids that plays a central role in cellular growth and development . Receptor Grade IGF-1 LR3 is a synthetic variant containing an extended N-terminal structure of 13 amino acids and an arginine substitution at position 3, resulting in an 83-amino acid peptide .

Key identifiers:

• Molecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉ 

• Molecular Weight: ~9,117.5 g/mol 

• Synonyms: Long-(arg3) insulin-like growth factor-I, LR3-IGF-1

• Purity: >95% by SDS-PAGE 

Mechanism of Action in Research

Enhanced Potency Through Reduced Binding

The structural modifications in IGF-1 LR3 serve a specific research purpose: the extended N-terminus and arginine substitution markedly decrease the peptide’s affinity for IGF binding proteins (IGFBPs) . Since IGFBPs typically inhibit the biological actions of IGFs, this reduced binding results in enhanced potency and bioavailability in research settings .

Receptor Binding Profile

Despite its reduced IGFBP binding, IGF-1 LR3 retains similar affinity for the type 1 IGF receptor as native IGF-1 . This allows researchers to study IGF-1 signaling pathways with a more potent and persistent tool.

Receptor Grade Distinction

The “Receptor Grade” designation indicates higher purity compared to Media Grade IGF-1 LR3, making it suitable for receptor-binding studies and sensitive signaling assays where purity is paramount .

Scientific Research Applications

Cell Culture and Proliferation Studies

Receptor Grade IGF-1 LR3 was specifically developed for supplementation of mammalian cell culture to support cell survival and proliferation . Supplementation at much lower concentrations than standard insulin concentrations can achieve equivalent or better productivity . Research suggests IGF-1 LR3 may be approximately 2.5-fold more potent than IGF-I in promoting anabolic effects in certain models .

Tissue Engineering and Regenerative Research

Emerging research has investigated IGF-1 LR3 in tissue engineering contexts. A 2024 study explored the use of a decellularized plant-based nerve conduit with controlled IGF-1 LR3 release to enhance nerve regeneration . The findings demonstrated significantly enhanced axonal regeneration and Schwann cell activity during the early stages of nerve repair .

Neuroscience and Cognitive Function Research

Research has explored IGF-1 LR3 in Alzheimer’s disease models. One study examined the effects of intranasal LR3-IGF-1 treatment in 5XFAD mice, investigating potential amyloid plaque remodeling and cognitive function .

Fetal Growth Research

A 2024 study investigated IGF-1 LR3 as a potential therapeutic for fetal growth restriction. One-week IGF-1 LR3 treatment in fetal sheep did not improve growth in FGR fetuses, though circulating amino acids decreased, suggesting increased amino acid utilization .

Muscle Research and Anabolic Studies

In studies on normal and dexamethasone-induced catabolic murine models, IGF-1 LR3 appeared to be 1.5 to 2 times as anabolic as IGF-I in inducing weight gain and increasing visceral organ weights . Research also suggested IGF-1 LR3 may reduce markers of muscle protein breakdown more effectively than IGF-I .

Why Choose Liaocheng Yixin Company?

When sourcing receptor grade igf-1 lr3 100mcg, quality and reliability are paramount. Here’s why researchers trust us:

Verified Quality Standards

Every batch meets rigorous specifications:

• Purity: >95% by SDS-PAGE 

• Biological Activity: ED50 <10 ng/ml, measured by dose-dependent proliferation of CHO cells 

• Endotoxin Level: <1 EU/μg by gel clotting method 

Research-Grade Specifications

• Appearance: White lyophilized powder

• Storage: Lyophilized product stable at -80°C for up to 6 months 

• Form: Lyophilized powder for research use

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using recombinant E. coli expression systems 

2. Purification via proprietary chromatographic techniques

3. Analysis using SDS-PAGE for purity verification

4. Biological Activity Testing via cell-based proliferation assays

5. Endotoxin Testing using LAL method

When you need premium receptor grade igf-1 lr3 100mcg for your cell culture, signaling, or regenerative research, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.