Buy ACE-031 (1mg) – Premium Research Grade Myostatin Inhibitor

Welcome to Liaocheng Yixin Company, your trusted source to buy ACE-031 1mg for research. As a licensed peptide synthesis manufacturer operating from our facility in Shandong Province, China, we provide high-quality research compounds for the global scientific community.

ACE-031 (also known as Ramatercept) is a recombinant fusion protein comprised of the extracellular domain of the activin receptor type IIB (ActRIIB) linked to the Fc region of human immunoglobulin IgG1 . It functions as a potent inhibitor of myostatin and other negative regulators of skeletal muscle mass . When you buy ACE-031 1mg for research, you gain access to a well-characterized tool for studies on muscle growth, muscular dystrophy, and age-related muscle loss. buy ace-031 1mg for research

What is ACE-031?

ACE-031 is a soluble ActRIIB receptor that acts as a myostatin inhibitor by binding to myostatin (GDF-8) and activin A, preventing these negative regulators from signaling through the native ActRIIB receptor . It is also known by the USAN/INN name Ramatercept.

Key identifiers:

• USAN/INN: Ramatercept

• Molecular Weight: ~77.24 kDa (dimer)

• Class: Recombinant fusion protein (ACVR2B-Fc)

• Target: Myostatin (MSTN) and activin A

• Purity: ≥99% verified by HPLC 

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Mechanism of Action in Research

ACE-031 promotes muscle growth through a well-characterized mechanism that has been validated in multiple research models .

ActRIIB Receptor Antagonism

ACE-031 acts as a soluble decoy receptor that binds to myostatin and other ActRIIB ligands . By preventing these negative regulators from signaling through the native ActRIIB receptor, it releases the brake on muscle growth. Research confirms that targeting myostatin and activin A simultaneously produces greater muscle growth than targeting myostatin alone .

Skeletal Muscle Growth and Function

Pharmacological blockade of myostatin and activin A through ACE-031 promotes significant muscle growth. In a non-human primate model, marmosets administered ACE-031 for 14 weeks showed significant increases in lean body mass and biceps brachii cross-sectional area of both type I and type II fibers . Ex vivo contractile properties showed increases in absolute and specific force production .

Half-Life and Pharmacokinetics

ACE-031 has a half-life of approximately 10-15 days, supporting sustained biological activity with infrequent dosing . This extended half-life is a key feature for research applications requiring prolonged exposure. buy ace-031 1mg for research

Scientific Research Applications

ACE-031 has been studied across multiple research domains, with clinical data supporting its efficacy .

Muscle Growth and Atrophy Research

Phase 1 clinical trials in healthy postmenopausal women demonstrated that a single 3 mg/kg dose of ACE-031 resulted in statistically significant increases in total body lean mass (3.3%) and thigh muscle volume (5.1%) . These results establish ACE-031 as a robust tool for investigating the effects of ActRIIB blockade on human muscle physiology.

Duchenne Muscular Dystrophy Research

ACE-031 was investigated in a Phase 2 clinical trial for Duchenne Muscular Dystrophy (DMD) . The study enrolled male subjects aged 4 years and older to evaluate safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple ascending doses . While the trial was terminated, it provides valuable research data on ActRIIB inhibition in neuromuscular disease models .

Bone and Fat Metabolism Research

Studies suggest ACE-031 affects bone and fat metabolism. Healthy volunteers receiving ACE-031 showed favorable changes in biomarkers of bone formation (increased BSAP) and fat mass (increased adiponectin, decreased leptin) .

Why Choose Liaocheng Yixin Company?

When you buy ACE-031 1mg for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC and mass spectrometry. Our ACE-031 meets ≥99% purity standards. Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• CAS Number: 1169766-01-1

• Appearance: Colorless to light yellow liquid

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• Storage: Store at -20°C or -80°C for long-term storage; shipping with dry ice recommended

• Form: Lyophilized powder or liquid for research use

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced biochemists using recombinant protein expression

2. Purification via protein chromatography

3. Analysis using HPLC and mass spectrometry for identity and purity verification

4. Activity testing to confirm ActRIIB binding and myostatin inhibition

5. Packaged under sterile conditions for research use

6. buy ace-031 1mg for research

: What is ACE-031 and how does it work in research?

A: ACE-031 is a recombinant fusion protein consisting of the ActRIIB receptor extracellular domain fused to human IgG1 Fc . It binds to myostatin and other negative regulators of muscle mass, preventing them from signaling and thereby promoting muscle growth . Research confirms that targeting both myostatin and activin A produces greater muscle growth than targeting myostatin alone .

: What is the half-life of ACE-031?

A: Clinical studies demonstrate ACE-031 has a half-life of approximately 10-15 days . This extended half-life supports sustained biological activity with infrequent dosing.

: What research applications use ACE-031?

A: ACE-031 is used in muscle growth and atrophy research, Duchenne Muscular Dystrophy studies, neuromuscular disease models, and metabolic research (bone and fat metabolism) .

: What is the evidence for ACE-031 efficacy?

A: Phase 1 clinical trials in healthy volunteers showed a 3.3% increase in total body lean mass and 5.1% increase in thigh muscle volume following a single 3 mg/kg dose . Preclinical studies in marmosets demonstrated increases in lean body mass and muscle fiber cross-sectional area . Phase 2 studies in DMD provided additional efficacy and safety data .

: Is this product for human use?

A: No. Our ACE-031 is manufactured strictly for research use only (RUO). It is not intended for human consumption or clinical applications.

When you need to buy ACE-031 1mg for research for your muscle biology, neuromuscular disease, or metabolic studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.