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Welcome to Liaocheng Yixin Company, your trusted source to buy AICAR 50mg online at competitive wholesale prices. As a licensed manufacturer operating from our facility in Shandong Province, China, we provide high-quality research compounds for the global scientific community.

AICAR (5-Aminoimidazole-4-carboxamide ribonucleoside), also known as Acadesine, is a synthetic nucleoside analogue widely used in research as a cell-permeable activator of AMP-activated protein kinase (AMPK) . It is not a peptide but is often studied alongside peptide-based tools in metabolic and cell-signaling research . When you buy AICAR 50mg online from us, you gain access to a well-characterized compound for investigating cellular energy sensing, glucose metabolism, and endurance pathways.

What is AICAR?

AICAR is a synthetic nucleoside analogue that serves as a precursor to ZMP (5-aminoimidazole-4-carboxamide ribonucleotide), an AMP analogue that directly activates AMPK . Its molecular formula is C₉H₁₄N₄O₅ with a molecular weight of 258.23 g/mol (CAS: 2627-69-2) . This compound is supplied as a lyophilized research material in 50mg vials .

Key identifiers:

• CAS Number: 2627-69-2 

• Molecular Formula: C₉H₁₄N₄O₅ 

• Molecular Weight: 258.23 g/mol 

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• Synonyms: Acadesine, AICA-Riboside 

• Purity: ≥98% (HPLC) 

Mechanism of Action in Research

AICAR is a potent and widely used research tool for activating the AMPK pathway, a master regulator of cellular energy metabolism .

AMPK Activation Pathway

Once inside the cell, AICAR is phosphorylated to ZMP, an AMP analogue that binds to and activates AMPK . This activation mimics the effects of cellular energy stress, such as low ATP or high AMP levels . AMPK activation leads to phosphorylation of downstream targets including acetyl-CoA carboxylase (ACC) and inhibition of mTOR signaling .

Metabolic Effects

In research models, AICAR has demonstrated the ability to promote glucose uptake in skeletal muscle through an insulin-independent mechanism . It may reduce hepatic glucose output and stimulate fatty acid oxidation while inhibiting lipolysis . It also inhibits PPARα transcription and antagonizes isoprenaline-induced lipolysis in adipocyte studies .

Endurance Research

Research in murine models demonstrated that AICAR may increase running endurance by 44% through activation of the AMPK-PPARδ pathway . This effect has been described as potentially mimicking some adaptive responses to exercise training in sedentary models.

Research Applications

Metabolic and Energy Research

• AMPK signaling pathway studies

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• Glucose uptake and insulin sensitivity investigations 

• Fatty acid oxidation and lipid metabolism research 

• Cellular energy-sensing models 

Endurance and Muscle Research

• Mitochondrial biogenesis and oxidative metabolism studies 

• Skeletal muscle adaptation research

• Exercise mimetic investigations 

Oncology Research

• Cancer cell viability and proliferation studies in MCF-7 breast cancer cells 

• Autophagy and apoptosis pathway research 

• AMPK/mTOR/ULK1 signaling investigations 

CYP450 Enzyme Research

• Studies on CYP4F2 expression regulation 

• AMPK-dependent gene expression investigations

Why Choose Liaocheng Yixin Company?

When you buy AICAR 50mg online from us, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed manufacturer with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC. Our AICAR meets ≥98% purity standards . Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥98% (HPLC) 

• CAS Number: 2627-69-2 

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• Molecular Weight: 258.23 g/mol 

• Appearance: Off-white powder 

• Solubility: Water (9 mg/mL), DMSO 

• Storage: Store at 4°C or -20°C 

• Form: Lyophilized powder for research use

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists

2. Purification via preparative HPLC

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4. Analysis using HPLC for purity verification (≥98%)

5. Mass Spectrometry for molecular weight confirmation

6. Packaged under sterile conditions for research use

FAQ Section

: What is AICAR and how does it work in research?

A: AICAR is a nucleoside analogue that serves as a cell-permeable AMPK activator . Once inside cells, it is phosphorylated to ZMP, which mimics AMP and activates AMPK. This is widely used to study cellular energy metabolism, glucose uptake, and fatty acid oxidation in research models .

: What are the key research applications for AICAR?

A: AICAR is used in metabolic research (AMPK signaling, glucose uptake), endurance and muscle studies (mitochondrial biogenesis), oncology research (cancer cell viability and autophagy), and CYP450 enzyme expression studies .

: Is AICAR approved for human use?

A: No. AICAR is strictly for research and laboratory use only. It is not intended for human consumption, therapeutic application, or diagnostic procedures .: What purity level can I expect?

A: All batches are tested to ensure ≥98% purity by HPLC analysis . Certificates of Analysis are available upon request.

: Is this product for human use?

A: No. Our AICAR is manufactured strictly for research use only (RUO). It is not intended for human consumption or clinical applications .

When you need to buy AICAR 50mg online at competitive wholesale pricing for your metabolic, endurance, or oncology research, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert synthesis capabilities with rigorous quality control to deliver research materials you can trust.