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5-Amino-1MQ (5-amino-1-methylquinolinium iodide) is a selective, substrate site-targeting inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT is an enzyme that methylates nicotinamide, consuming the methyl donor SAM, and influencing key pathways like NAD+ biosynthesis and cellular methylation potential. When you buy 5-Amino-1MQ for research, you gain access to a well-characterized tool for metabolic, muscle regeneration, and oncology studies. buy 5-amino-1mq for research

What is 5-Amino-1MQ?

5-Amino-1MQ is a small, membrane-permeable molecule that functions as a selective NNMT inhibitor with an IC50 of 1.2 μM. It has been validated across numerous preclinical models for its effects on obesity-related metabolic dysfunction, muscle regeneration, and cancer metastasis.

Key identifiers:

• Purity: ≥98% verified by HPLC

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• Form: Powder

• Color: Faint red to dark brown

• Solubility: DMSO (2 mg/mL, clear)

• Storage: -20°C

Mechanism of Action in Research

NNMT Inhibition

5-Amino-1MQ binds to the substrate site of NNMT, competitively inhibiting the methylation of nicotinamide. This block prevents the conversion of SAM to SAH, preserving the cellular methylation potential (SAM/SAH ratio).

NAD+ Salvage Pathway Modulation

By inhibiting NNMT consumption of nicotinamide, 5-Amino-1MQ increases the availability of nicotinamide for the NAD+ salvage pathway. This leads to increased cellular NAD+ levels, activating NAD+-dependent enzymes including SIRT1.

Selectivity Profile

5-Amino-1MQ demonstrates high selectivity for NNMT over related methyltransferases and NAD+ salvage pathway enzymes:

• NNMT IC50: 1.2 μM

• Off-target effects: Does not significantly inhibit DNA methyltransferase 1 (DNMT1), protein arginine methyltransferase 3 (PRMT3), catechol-O-methyltransferase (COMT), nicotinamide phosphoribosyltransferase (NAMPT), or SIRT1

• Selectivity margin: At least 83-fold selectivity over tested off-targets

Research Applications

Metabolic and Obesity Research

Preclinical studies demonstrate that 5-Amino-1MQ reverses key features of diet-induced obesity (DIO) in murine models:

• Dosing: 20 mg/kg/day subcutaneous

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• Efficacy: Corrects serum chemistry markers, triglycerides, ALT, AST, and ketone bodies

• Mechanism: Reduces lipogenesis in 3T3-L1 adipocytes (EC50 = 30 μM) and lowers intracellular 1-MNA levels (EC50 = 2.3 μM)

Muscle Regeneration Research

5-Amino-1MQ has demonstrated significant efficacy in activating senescent muscle stem cells:

• Aged mice (24 months): 1.8-fold increase in cross-sectional area of regenerating muscle fibers after injury

• Satellite cell activation: 60-75% increase in proliferating satellite cells

• Functional outcome: ~70% increase in peak torque (strength) compared to controls

• Mechanism: Effects were abolished in MuSC-specific SIRT1 knockout models, confirming the NAD+-SIRT1 axis

Oncology Research

5-Amino-1MQ has been studied in models of ovarian cancer metastasis:

• Dosing: 20 mg/kg/day intraperitoneal in HeyA8 ovarian cancer metastasis model

• Safety: No adverse effects observed in animals up to 60 mg/kg/day

Pharmacokinetic Profile

Validated pharmacokinetics in rats using LC-MS/MS methodology:

• Oral bioavailability: 38.4%

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• Cmax (oral): 2252 ng/mL

• AUC0-∞ (IV): 3708 h·ng/mL; (oral): 14431 h·ng/mL

• Half-life: 3.80 ± 1.10 h (IV) and 6.90 ± 1.20 h (oral)

Important Research Considerations

Regulatory Status

As of 2026, 5-Amino-1MQ is a preclinical research compound and has not entered the FDA regulatory pathway. No IND application has been announced, no Phase 1 trial has been registered, and the compound has no projected approval timeline. This is strictly a research compound.

Safety Profile

The human safety profile of 5-Amino-1MQ has not been established. Theoretical concerns include unknown effects on cellular methylation broadly, unknown drug interactions, and unknown long-term effects on cancer biology. No formal contraindications derived from human data exist.

Why Choose Liaocheng Yixin Company?

When you buy 5-amino-1mq for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed manufacturer with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC. Our 5-Amino-1MQ meets ≥98% purity standards. Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥98% verified by HPLC

• Form: Powder

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• Color: Faint red to dark brown

• Solubility: DMSO (2 mg/mL, clear)

• Storage: -20°C

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists

2. Purification via preparative HPLC

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4. Analysis using HPLC for purity verification (≥98%)

5. Mass Spectrometry for molecular weight confirmation

6. Packaged under sterile conditions for research use

FAQ Section

: What is 5-Amino-1MQ and how does it work in research?

A: 5-Amino-1MQ is a selective inhibitor of nicotinamide N-methyltransferase (NNMT) with an IC50 of 1.2 μM. By inhibiting NNMT, it preserves cellular methylation potential, increases NAD+ levels, and activates NAD+-dependent pathways including SIRT1.

: What are the key research applications for 5-Amino-1MQ?

A: 5-Amino-1MQ is used in metabolic and obesity research, muscle regeneration and satellite cell activation studies, and oncology research. It has been validated in DIO mouse models, aged mouse muscle injury models, and ovarian cancer metastasis models.

: Is 5-Amino-1MQ approved for human use?

A: No. As of 2026, 5-Amino-1MQ is a preclinical research compound that has not entered the FDA regulatory pathway. It is strictly for research use only.

: What purity level can I expect?

A: All batches are tested to ensure ≥98% purity by HPLC analysis. Certificates of Analysis are available upon request.

: Is this product for human use?

A: No. Our 5-Amino-1MQ is manufactured strictly for research use only (RUO). It is not intended for human consumption or clinical applications.

When you need premium 5-amino-1mq for research for your metabolic, muscle regeneration, or oncology studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert synthesis capabilities with rigorous quality control to deliver research materials you can trust.