Dihexa

Dihexa – Premium Research Compound for Cognitive Science

Welcome to Liaocheng Yixin Company, your trusted source for premium dihexa peptide for sale. As a specialized peptide synthesis manufacturer operating from our facility at No. 9 Lushan Road, Dongcheng Street, Liaocheng Economic and Technological Development Zone, Shandong Province, we provide high-quality research compounds for the global scientific community.

Dihexa is an advanced oligopeptide compound that has garnered significant attention in neuroscience research for its unique properties and mechanism of action. Our dihexa peptide for sale offers researchers a reliable, high-purity compound for their investigative work in cognitive function and neuroplasticity studies.

What is Dihexa?

Dihexa (also known as PNB-0408, or scientifically as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a derivative of angiotensin IV with the CAS number 1401708-83-5 and molecular formula C27H44N4O5 . It was developed as a metabolically stabilized analog of the angiotensin IV-related peptide Nle1-AngIV, designed to overcome the limitations of earlier peptides that were susceptible to metabolic degradation and unable to penetrate the blood-brain barrier .

Key identifiers:

• CAS Number: 1401708-83-5

• Molecular Weight: 504.66 g/mol 

• Formula: C27H44N4O5

• Synonyms: PNB-0408; Hexanoyl-Tyr-Ile-Ahx-NH2; N-hexanoic-Try-Ile-(6)-amino hexanoic amide

Mechanism of Action in Research

Dihexa’s research significance stems from its unique interaction with the hepatocyte growth factor (HGF)/c-Met system. Dihexa binds to hepatocyte growth factor (HGF) with exceptionally high affinity, demonstrating a Kd value of 65 pM . This binding potentiates HGF’s activity at its receptor, c-Met, triggering downstream signaling pathways involved in neuronal growth and synaptic plasticity .

Key research observations:

• Synaptogenic activity: Dihexa induces hippocampal spinogenesis and synaptogenesis similar to HGF itself 

• Neuronal protection: Studies demonstrate HGF-dependent protection of neuronal cells through c-Met signaling mechanisms 

• Cognitive function studies: Dihexa has been studied for its ability to reverse scopolamine-induced learning deficits in animal models 

Applications in Scientific Research

Research applications for dihexa include:

• Alzheimer’s disease research: Preclinical studies have examined dihexa’s potential to support cognitive function and neuronal health 

• Synaptic plasticity studies: Investigating mechanisms of spinogenesis and synaptogenesis in hippocampal neurons 

• Neuroprotection research: Studies evaluating protective effects on neuronal cells through HGF/c-Met pathway activation 

• Cognitive enhancement research: Examining procognitive properties in various experimental models 

Why Choose Liaocheng Yixin Company?

When sourcing dihexa peptide for sale, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards, ensuring every product meets research-grade specifications.

Verified Purity Standards

Every batch undergoes rigorous testing to ensure minimum 99% purity. We provide Certificates of Analysis with every order.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• Appearance: White to off-white solid 

• Solubility: Soluble in DMSO (≥52.4 mg/mL), ethanol (≥4.21 mg/mL with ultrasonic), insoluble in water 

• Storage: Powder at -20°C for up to 3 years; in solvent at -80°C for 6 months 

Quality Assurance & Testing

Every batch of dihexa peptide for sale undergoes comprehensive quality control:

1. Synthesis by experienced chemists using advanced techniques

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. Packaged in sterile conditions for research use

When you need premium dihexa peptide for sale for your neuroscience research, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.