Epithalon (25mg) – Premium Research Peptide for Longevity & Circadian Studies

Welcome to Liaocheng Yixin Company, your trusted source for premium epithalon 25mg peptide for research. As a specialized peptide synthesis manufacturer operating from our facility at No. 9 Lushan Road, Dongcheng Street, Liaocheng Economic and Technological Development Zone, Shandong Province, we provide high-quality research compounds for the global scientific community.

•  epithalon 25mg peptide for research

Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) that mimics the naturally occurring polypeptide Epithalamin, which is produced in the pineal gland region of the brain . This peptide has been the subject of over 15 years of research for its ability to regulate telomerase activity and influence circadian rhythms . Our epithalon 25mg peptide for research offers investigators a reliable, high-purity compound for longevity, cellular senescence, and chronobiology studies.

What is Epithalon?

Epithalon (also known as Epitalon or Epithalone) is a synthetic tetrapeptide composed of the amino acid sequence Ala-Glu-Asp-Gly (AEDG) . It is the defined synthetic version of Epithalamin, a crude polypeptide extract derived from the pineal gland .

Key identifiers:

• CAS Number: 307297-39-8 

• Molecular Formula: C₁₄H₂₂N₄O₉ 

• Molecular Weight: 390.35 g/mol 

• Sequence: H-Ala-Glu-Asp-Gly-OH (AEDG) 

• Synonyms: Epitalon, Epithalone, AEDG peptide 

• Purity: ≥99% verified by HPLC 

•  epithalon 25mg peptide for research

Mechanism of Action in Research

Epithalon exerts its effects through two primary pathways that intersect in aging and cellular health research.

Telomerase Activation

Epithalon’s most studied mechanism is the induction of telomerase activity in human somatic cells . Telomerase is the enzyme responsible for maintaining and extending telomeres—the protective DNA sequences at the ends of chromosomes that shorten with each cell division . Research by Khavinson et al. (PMID 12937682) demonstrated that Epithalon induces both telomerase activity and telomere elongation in telomerase-negative human fetal fibroblast cultures .

Circadian Rhythm Regulation

Epithalon functions as a multi-pathway chronobiotic modulator, influencing the master circadian clock in the suprachiasmatic nucleus (SCN) . It restores pineal gland function and stimulates melatonin production, which declines significantly with age . A randomized clinical study demonstrated that Epithalon administration can modulate core clock gene expression, decreasing Clock while doubling Cry2 expression—indicating capacity to re-entrain disrupted biological rhythms at the genomic level .

Scientific Research Applications

Aging and Longevity Research

Epithalon is the anchor of the longevity peptide category and is frequently studied for its geroprotective properties . Research has shown that Epithalon activates telomerase, extending telomeres and supporting continued cell division . The peptide suppresses CCL11 and HMGB1 genes, increasing lifespan in test subjects .

Anti-Aging and Cellular Senescence

Epithalon has demonstrated anti-aging effects through telomerase-mediated telomere maintenance and antioxidant activity . Studies have reported significant antioxidant effects and inhibition of carcinogenic receptor expression, prompting research into potential anti-tumor applications .

•  epithalon 25mg peptide for research

Sleep and Circadian Research

Given its pineal gland origin, Epithalon is studied for its ability to restore and normalize melatonin levels in older patients . Research indicates it can improve disrupted sleeping patterns through circadian rhythm restoration .

Metabolic Research

Epithalon has shown metabolic benefits in research settings, including improved glucose tolerance and decreased insulin and triglyceride levels . These findings support investigation into its broader systemic effects.

Immunology and Inflammation

Epithalon has been investigated as a potential research tool in inflammation studies due to its ability to regulate biomolecules involved in the inflammatory process, such as cytokines and C-reactive protein .

Why Choose Liaocheng Yixin Company?

When sourcing epithalon 25mg peptide for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. Our Epithalon meets ≥99% purity standards . Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC 

• Appearance: White lyophilized powder

• Solubility: H₂O: ≥40 mg/mL (with sonication) 

• Storage: Powder at -20°C for up to 3 years; in solvent at -80°C for up to 1 year 

• Form: Lyophilized powder for research use

•  epithalon 25mg peptide for research

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. Packaged in sterile conditions for research use

: What is Epithalon and how does it work in research?

A: Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland polypeptide Epithalamin . It activates telomerase, the enzyme responsible for maintaining telomeres, supporting cellular replication and DNA integrity . It also regulates circadian rhythms by restoring pineal function and modulating core clock gene expression .

: What is the significance of Epithalon’s telomerase activation?

A: Research by Khavinson et al. demonstrated that Epithalon induces telomerase activity and telomere elongation in human somatic cells . Telomerase activation is the basis for Epithalon’s longevity research applications, as telomere shortening is a hallmark of cellular aging .

: What research applications use Epithalon?

A: Epithalon is used in aging and longevity research, cellular senescence studies, sleep and circadian rhythm research, metabolic studies, and immunology investigations .

: What is the typical dosage used in research?

A: Research protocols vary, but 25mg vials are standard for reconstitution and experimental use. Epithalon is typically administered in short cycles rather than continuously . The peptide is for research use only.

•  epithalon 25mg peptide for research

: What purity level can I expect?

A: All batches are tested to ensure ≥99% purity by HPLC analysis . Certificates of Analysis are available upon request.

: Is this product for human use?

A: No. Our Epithalon is manufactured strictly for research use only (RUO). It is not intended for human consumption or clinical applications .

When you need premium epithalon 25mg peptide for research for your longevity, cellular senescence, or chronobiology studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.