Selank (10mg) – Premium Anxiolytic Heptapeptide for Research

Welcome to Liaocheng Yixin Company, your trusted source for premium selank 10mg peptide for research. As a specialized peptide synthesis manufacturer operating from our facility in Shandong Province, China, we provide high-quality research compounds for the global scientific community. selank 10mg peptide for research

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide analogue of the endogenous immunomodulatory peptide tuftsin that exhibits prolonged anti-anxiety and nootropic effects . Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Selank represents a unique research tool for investigating the intersection of neurochemistry, immunology, and behavioral neuroscience . Our selank 10mg peptide for research offers investigators a reliable, high-purity compound for advanced neuropharmacological and behavioral studies.  selank 10mg peptide for research

What is Selank?

Selank is a synthetic heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP) and a molecular weight of 751.90 g/mol . It is structurally related to the immunomodulatory peptide tuftsin, retaining immune-modulating properties while exhibiting significant effects on the central nervous system .

Key identifiers:

• Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)

• Molecular Weight: 751.90 g/mol

• Synonyms: Selank diacetate, Selank acetate

• Purity: ≥99% verified by HPLC

Mechanism of Action in Research

Selank operates through multiple molecular pathways, making it a fascinating research subject in neuroscience:

GABAergic System Modulation

Selank acts as a positive allosteric modulator of GABA-A receptors, enhancing the inhibitory effects of GABA without directly binding to the benzodiazepine site . This indirect modulation may contribute to its anxiolytic effects without causing sedation. Studies show that Selank affects [³H]GABA binding and can block the modulatory activity of Diazepam and Olanzapine .

Enkephalin Degradation Inhibition

Selank inhibits enzymes responsible for the degradation of enkephalins—endogenous opioid peptides with anxiolytic properties . The peptide dose-dependently inhibits enkephalin hydrolysis in blood serum (IC50 ≈ 15 µM) and is more effective than known peptidase inhibitors bacitracin and puromycin .

Neurotrophic Factor Regulation

Selank rapidly increases the expression of Brain-Derived Neurotrophic Factor (BDNF) in the hippocampus following intranasal administration . BDNF is critical for neuronal survival, synaptic plasticity, and cognitive function .

Immunomodulation

As a tuftsin analogue, Selank influences the immune system by suppressing IL-6 gene expression and modulating T-helper cell (Th1/Th2) balance .

Neurotransmitter Modulation

Selank increases norepinephrine levels in the hypothalamus and modulates dopamine and serotonin metabolites in a strain-dependent manner, providing insight into its effects on monoamine systems .selank 10mg peptide for research

Scientific Research Applications

Anxiety Research

Selank has demonstrated anxiolytic effects comparable to the benzodiazepine medazepam in clinical studies of patients with Generalized Anxiety Disorder (GAD) and neurasthenia, but without associated sedation, cognitive impairment, or withdrawal symptoms . Research shows Selank reduces behavioral manifestations of anxiety while exhibiting anti-asthenic and psychostimulant properties .selank 10mg peptide for research

Cognitive Enhancement and Neuroprotection

Selank improves learning and memory processes in animal models and has been shown to compensate for cognitive deficits induced by hypoxia . Research in elderly patients with cognitive disorders of vascular origin demonstrated:

• Reduction in internal stress, irritability, and anxiety

• Increased vigor, improved mood, and enhanced stress resistance

• Improved ability to concentrate and reduced forgetfulness

• Increased speed of sensorimotor reactions and improvement in short-term visual memory

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Neuroprotection and Ischemia Research

Recent transcriptomic studies reveal that Selank exhibits protective effects in cerebral ischemia-reperfusion models by:

• Upregulating protective genes (Hspa1, Hmox1)

• Downregulating microglial genes associated with neuroinflammation (P2ry12)

• Modulating major histocompatibility complex gene expression to exert immunomodulatory effects 

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Synergy Studies

Research indicates that Selank may act synergistically with other compounds. Factorial designs assessing combined administration with diazepam have shown a synergistic anxiolytic effect that is state-dependent and requires careful methodological approaches .selank 10mg peptide for research

Why Choose Liaocheng Yixin Company?

When sourcing selank 10mg peptide for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC and mass spectrometry. Certificates of Analysis confirming purity exceeding 99% are available upon request.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)

• Molecular Weight: 751.90 g/mol

• Appearance: White lyophilized powder

• Storage: Store powder at -20°C in a sealed, desiccated container, protected from light and moisture

• Form: Lyophilized powder for research use

• selank 10mg peptide for research

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. Packaged under sterile conditions for research use

6. selank 10mg peptide for research

: What is Selank and how does it work in research?

A: Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) that acts as a positive allosteric modulator of GABA-A receptors, inhibits enkephalin degradation, increases BDNF expression, and modulates immune function .

: What are the key research applications for Selank?

A: Selank is used in anxiety research (GAD, stress models), cognitive enhancement studies, neuroprotection research, immunomodulation studies, and synergy research with other compounds.

: What is the evidence base for Selank’s anxiolytic effects?

A: Clinical studies have shown Selank’s anxiolytic effects are comparable to medazepam, but without sedative or amnestic side effects . However, international RCTs and large-scale human safety data beyond 30 days do not currently exist .

: What purity level can I expect?

A: All batches are tested to ensure ≥99% purity by HPLC analysis. Certificates of Analysis are available upon request.

: Is this product for human use?

A: No. Our Selank is manufactured strictly for research use only (RUO). It is not intended for human consumption or clinical applications.

When you need premium selank 10mg peptide for research for your neuropharmacological, behavioral, or immunomodulatory studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust .selank 10mg peptide for research