N-Acetyl Selank (10mg) – Premium Research Peptide for Neuroscience & Neuroimmunology Studies

Welcome to Liaocheng Yixin Company, your trusted source for premium n-acetyl selank 10mg for research. As a specialized peptide synthesis manufacturer operating from our facility in Shandong Province, China, we provide high-quality research compounds for the global scientific community.

N-Acetyl Selank is a modified form of the heptapeptide Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro), a synthetic analog of the endogenous immunomodulatory tetrapeptide tuftsin, originally developed by the Institute of Molecular Genetics of the Russian Academy of Sciences . The N-acetylation enhances metabolic stability and may improve bioavailability—making it a valuable tool for studying neuropeptide function, receptor interactions, and the neuroimmune axis . Our n-acetyl selank 10mg for research offers investigators a reliable, high-purity compound for neuroscience, neuroimmunology, and behavioral research.

What is N-Acetyl Selank?

N-Acetyl Selank (CAS: 129954-34-3) is the N-terminally acetylated derivative of Selank, a synthetic heptapeptide that builds upon the endogenous tetrapeptide tuftsin (Thr-Lys-Pro-Arg) with a stabilizing Pro-Gly-Pro extension . This structural modification serves a clear research purpose: the acetyl group protects the peptide from aminopeptidase-mediated degradation, extending its in vivo half-life and potentially improving central nervous system penetration . It is important to distinguish N-Acetyl Selank from N-Acetyl Selank Amidate, which has both N-terminal acetylation and C-terminal amidation—a more heavily modified analog with even less independent research .

Key Identifiers:

• CAS Number: 129954-34-3

• Molecular Formula: C₃₃H₅₇N₁₁O₉

• Molecular Weight: 751.89 g/mol 

• Sequence: Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH 

• Synonyms: N-Acetyl Selank, Acetylated Selank

• Purity: ≥99% verified by HPLC

Mechanism of Action in Research

N-Acetyl Selank’s research value comes from its multi-target pharmacology, bridging neuroscience and immunology through multiple pathways:

GABAergic Anxiolysis 

Selank and its N-acetyl derivative enhance GABAergic neurotransmission in the amygdala, hippocampus, and prefrontal cortex. The peptide increases GABA binding affinity at GABA-A receptors through an allosteric mechanism distinct from benzodiazepines, enhancing chloride conductance without producing sedation, tolerance, or physical dependence. In research, this mechanism allows investigation of non-sedating anxiolytic pathways—a distinct advantage over benzodiazepine-based study models .

BDNF & Neuroplasticity

N-Acetyl Selank increases expression of brain-derived neurotrophic factor (BDNF) and its receptor TrkB in hippocampal neurons . BDNF/TrkB signaling activates cascades that support long-term potentiation (LTP), dendritic spine formation, and neurogenesis—the cellular substrates of learning and memory. This makes the peptide a tool for studying neurotrophic pathways and cognitive enhancement mechanisms .

Enkephalinase Inhibition

Selank has been reported to inhibit peptide-degrading enzymes such as enkephalinases, thereby elevating endogenous regulatory peptides like enkephalins . This positions N-Acetyl Selank as a modulator of endogenous opioid peptide systems, valuable for research into pain, mood, and stress response pathways .

Immunomodulation

Inherited from its tuftsin core, Selank modulates cytokine expression (including IL-6) and influences T-helper cell balance (Th1/Th2) . This neuroimmune bridge makes N-Acetyl Selank relevant for investigating stress-immune interactions and inflammation-linked behavioral states .

Scientific Research Applications

N-Acetyl Selank is a research tool across multiple domains, though it’s important to note that independent clinical validation for the acetylated form specifically is sparse—most evidence is extrapolated from the parent compound Selank .

Anxiety & Stress Research

Clinical data on the parent compound Selank demonstrated anxiolytic efficacy comparable to medazepam in patients with generalized anxiety disorder, with additional antiasthenic and psychostimulant effects . The acetylated form is expected to achieve equivalent effects with potentially lower dosing frequency due to enhanced stability . Unlike traditional anxiolytics, Selank produces no sedation, no cognitive impairment, and no observed dependence or withdrawal—making it a valuable comparator in behavioral pharmacology .

Cognitive & Nootropic Research

Selank has been associated with improved learning and memory, increased sensory attention, and enhanced mental clarity in research settings . The nootropic effects are attributed to BDNF-mediated neuroplasticity, cholinergic modulation, and stabilization of enkephalin metabolism in the brain . N-Acetyl Selank’s extended stability may produce more sustained gene expression changes related to neuroplasticity .   n-acetyl selank 10mg for research

Neuroimmune Research

Selank’s immunomodulatory profile—including IL-6 modulation and T-helper cell balance effects—positions N-Acetyl Selank as a tool for neuroimmune axis studies . This is particularly relevant for research exploring the psychological and immunological components of stress-related disorders .

Receptor Binding & Structure-Activity Studies

The acetylated modification provides a scaffold for examining how N-terminal acetylation influences peptide function, receptor affinity, and metabolic stability . Researchers utilize this analog to compare native versus modified peptide bioactivity and degradation profiles—critical for advancing peptide engineering and rational compound design .

Important Research Limitations

Direct published evidence on N-Acetyl Selank specifically is thinner than the Selank literature might suggest. What exists is largely the assumption that the modified form retains Selank effects while lasting longer—a plausible assumption since the core active sequence is preserved, but not the same as independent validation . The strongest data describes the parent molecule, not this specific modification .

Why Choose Liaocheng Yixin Company?

When sourcing n-acetyl selank 10mg for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• Appearance: White lyophilized powder

• Storage: Store powder at -20°C in a sealed container, protected from light and moisture

• Form: Lyophilized powder for research use

•  n-acetyl selank 10mg for research

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. Packaged in sterile conditions for research use

When you need premium n-acetyl selank 10mg for research for your neuroscience, neuroimmunology, or behavioral studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.