N-Acetyl Semax (25mg)

N-Acetyl Selank (10mg) – Premium Research Peptide for Neuroscience & Neuroimmunology Studies

Welcome to Liaocheng Yixin Company, your trusted source for premium n-acetyl semax 25mg for research. As a specialized peptide synthesis manufacturer operating from our facility in Shandong Province, China, we provide high-quality research compounds for the global scientific community.

N-Acetyl Semax is a modified, potentiated form of the synthetic heptapeptide Semax (Met-Glu-His-Phe-Pro-Gly-Pro) . It was developed by adding an N-acetyl group to the parent peptide, which is based on the ACTH(4-10) fragment. This modification enhances resistance to enzymatic degradation, improves metabolic stability, and may facilitate blood-brain barrier penetration . Our n-acetyl semax 25mg for research offers investigators a reliable, high-purity tool for neurobiology, cognitive function, and neuroprotection studies.

What is N-Acetyl Semax?

The parent compound Semax has been approved in Russia and several CIS countries as a nootropic and neuroprotective agent for conditions including stroke, cognitive disorders, and optic nerve disease . N-Acetyl Semax represents a next-generation optimization with enhanced stability and potentially greater potency . Unlike the standard Semax which is rapidly degraded by plasma aminopeptidases (half-life of several minutes), the acetylated form has an estimated half-life 3-10 times longer .

Key Identifiers:

• CAS Number: 129954-34-3

• Molecular Formula: C₃₇H₅₁N₉O₁₀S

• Molecular Weight: ~858.97 g/mol 

• Sequence: Ac-Met-Glu-His-Phe-Pro-Gly-Pro (Ac-MEHFPGP) 

• Synonyms: AC-SEMAX, ACTH (4-7)PGP

• Purity: ≥99% verified by HPLC

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Mechanism of Action in Research

N-Acetyl Semax exerts its effects through multiple converging mechanisms that make it valuable for neuroscience research:

Neurotrophin Upregulation

The most well-characterized mechanism is robust upregulation of brain-derived neurotrophic factor (BDNF) and its receptor TrkB in the hippocampus, prefrontal cortex, and basal forebrain . Research demonstrates that Semax increases BDNF mRNA and protein levels in these regions critical for learning, memory, and executive function. It also upregulates nerve growth factor (NGF) and glial cell-derived neurotrophic factor (GDNF), shifting the NGF/BDNF ratio toward BDNF dominance . This BDNF/TrkB activation drives MAPK/ERK, PI3K/Akt/mTOR, and PLCγ/CaMKII pathways that strengthen long-term potentiation (LTP), promote dendritic spine remodeling, and stimulate adult hippocampal neurogenesis .

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Melanocortin Receptor Modulation

As an ACTH(4-10) analog, N-Acetyl Semax retains affinity for melanocortin-3 (MC3R) and melanocortin-4 (MC4R) receptors in the CNS . MC4R activation in the hippocampus and cortex stimulates adenylyl cyclase/cAMP/PKA and ERK signaling, modulating attention, memory consolidation, and motivation. Importantly, this melanocortinergic activity is dissociated from the MC2R-mediated adrenal effects of full-length ACTH, allowing cognitive benefits without cortisol elevation . 

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Neurotransmitter System Modulation

N-Acetyl Semax modulates dopamine and serotonin systems by increasing tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) expression and modulating monoamine transporter activity . Research shows that Semax increases striatal levels of 5-hydroxyindoleacetic acid (5-HIAA), a serotonin metabolite, by up to 180% . It also enhances the dopaminergic system’s responsiveness, potentiating the actions of dopaminergic agonists . Additionally, Semax may inhibit enkephalin-degrading enzymes, leading to increased levels of endogenous enkephalins that play roles in nociception and stress response .

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Neuroprotection in Ischemia

N-Acetyl Semax inherits the neuroprotective profile of Semax, which is clinically approved in Russia for ischemic stroke treatment. Its mechanism involves suppression of microglial activation, reduction of inflammatory cytokine release (IL-1β, TNF-α), reduction of glutamate excitotoxicity, stabilization of the blood-brain barrier, and promotion of neurovascular unit survival through BDNF-TrkB and VEGF signaling . A 2019 study in the Pharmaceutical Chemistry Journal specifically identified N-acetyl-Semax as the “most promising” modification for minimizing proteolysis during brain delivery . 

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Scientific Research Applications

Cognitive Function Studies

N-Acetyl Semax is employed in behavioral neuroscience to investigate mechanisms of learning, memory, and cognitive performance . Clinical data on the parent compound Semax demonstrated cognitive enhancement at standard doses (200-600 mcg, 2-3 times daily) in healthy volunteers . Studies on experimental models under stress showed enhanced memory and attention 24 hours after peptide exposure, with no reported negative side effects . Research suggests the peptide may have potential in models of separation anxiety and SSRI-related behavioral effects .

Neuroprotection and Ischemia Research

The peptide serves as a research agent for examining molecular mechanisms of neuroprotection and synaptic plasticity . In acute ischemic stroke research, high-dose Semax (12 mg/day intranasal for 5 days) accelerated neurological recovery in 100 patients compared to placebo . In animal models, Semax prevented hippocampal CA1 neuronal death following transient global ischemia . The peptide modulates expression of over 1,000 genes related to inflammation, apoptosis, and neuroplasticity in ischemic brain tissue .

Peptide Receptor Binding and SAR Studies

N-Acetyl Semax is frequently employed in receptor binding assays to elucidate interaction profiles of modified neuropeptides with their target receptors . Researchers utilize this analog to dissect structural determinants of peptide-receptor engagement and map contributions of N-terminal acetylation to functional properties .

Peptide Stability and Formulation Research

As a model for studying N-terminal modifications on peptide longevity, N-Acetyl Semax is used in comparative assays to assess degradation rates, metabolic processing, and structural resilience under various experimental conditions . Studies have confirmed that the acetylated modification improves resistance to proteolytic cleavage during transversal of the enzyme barrier in the olfactory epithelium . 

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Important Research Consideration

Direct published evidence on N-Acetyl Semax specifically is thinner than the Semax literature might suggest . The strongest data describes the parent molecule (Semax), not this specific modification. However, researchers consider the acetylated version “most promising” based on stability studies . The exact dose equivalence ratios for N-Acetyl Semax have not been established in published research, though enhanced stability predicts equivalent effects at lower doses .

Why Choose Liaocheng Yixin Company?

When sourcing n-acetyl semax 25mg for research, quality and reliability are paramount. Here’s why researchers trust us:

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Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• Appearance: White lyophilized powder

• Storage: Store powder at -20°C in a sealed container, protected from light and moisture

• Form: Lyophilized powder for research use

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Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. Packaged in sterile conditions for research use

6. n-acetyl selank 10mg for research

When you need premium n-acetyl semax 25mg for research for your neuroscience, cognitive, or neuroprotection studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.