TB-500 (Thymosin Beta 4) (5mg) – Premium Research Peptide

Welcome to Liaocheng Yixin Company, your trusted source for premium tb-500 thymosin beta 4 5mg for research. As a specialized peptide synthesis manufacturer operating from our facility at No. 9 Lushan Road, Dongcheng Street, Liaocheng Economic and Technological Development Zone, Shandong Province, we provide high-quality research compounds for the global scientific community.

TB-500 is a synthetic peptide fragment derived from the naturally occurring protein Thymosin Beta-4, which plays fundamental roles in cell structure, migration, and tissue repair . While full Thymosin Beta-4 is a 43-amino acid protein, TB-500 represents a smaller, more readily distributed fragment that retains its core biological activity . Our tb-500 thymosin beta 4 5mg for research offers investigators a reliable, high-purity compound for tissue repair, angiogenesis, and regenerative research. tb-500 thymosin beta 4 5mg for research

What is TB-500?

TB-500 (also known as TB-Frag) is a synthetic heptapeptide (Ac-LKKTETQ) that corresponds to amino acids 17–23 of thymosin beta-4 . The sequence LKKTETQ is the region responsible for the protein’s primary biological activity . This fragment is distinguished from the full endogenous protein by its N-terminal acetylation, a modification that enhances both stability and biological activity .

Key identifiers:

• CAS Number: 885340-08-9 

• Molecular Formula: C38H68N10O14 

• Molecular Weight: 889.01 g/mol 

• Sequence: Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (Ac-LKKTETQ) 

• Synonyms: TB-500, TB-Frag, Thymosin Beta 4 Fragment

• Purity: ≥99% verified by HPLC 

Mechanism of Action in Research

TB-500 exerts its effects through several well-characterized mechanisms:

1. Actin Regulation and Cell Migration

The best-characterized mechanism of TB-500 is its high-affinity binding to G-actin, the monomeric, globular form of actin . This binding sequesters G-actin and enables rapid cytoskeletal remodeling. Actin is the structural protein that determines cell shape, movement, and division. By regulating actin dynamics, TB-500 facilitates the migration of repair cells—including fibroblasts, stem cells, and progenitor cells—to sites of injury .

2. Angiogenesis – Building New Blood Supply

TB-500 upregulates VEGF (Vascular Endothelial Growth Factor) expression by 2.5 to 3.8-fold across multiple cell types in research settings . VEGF is the primary driver of angiogenesis, the formation of new blood vessels. This is critical for tissue repair, since healing tissue cannot receive oxygen, nutrients, or immune cells without adequate blood supply . Research by Smart et al. in Angiogenesis (2007) documented TB-500’s ability to stimulate new blood vessel formation .

3. Anti-Inflammatory Activity

Research shows that Thymosin Beta-4, produced by monocytes in response to tissue injury, blocks neutrophil chemotaxis and reduces macrophage infiltration at injury sites . This represents a meaningful anti-inflammatory signal rather than a blunt suppression of immune function .

Scientific Research Applications

TB-500 has been studied across multiple research domains:

Tissue Repair and Regeneration Research

• TB-500’s actin-regulatory mechanism accelerates repair across muscles, tendons, ligaments, and skin 

• In animal wound healing models, TB-500 increases collagen deposition and angiogenesis in affected tissue 

• Research indicates potential for reducing scar tissue formation and adhesions following injury 

• tb-500 thymosin beta 4 5mg for research

Cardiovascular Research

• TB-500 demonstrates cardioprotective effects through preservation of cardiac muscle viability following ischemic injury 

• Studies suggest the peptide may attenuate scar tissue formation following myocardial infarction and promote neovascularization within ischemic cardiac tissue 

Angiogenesis Studies

• TB-500 promotes endothelial cell migration, capillary tubule formation, and stabilization of new vascular networks 

• The LKKTET sequence is recognized as critical to angiogenic activity 

Important Research Note

Recent scientific investigations have provided important context for TB-500 research. A 2024 study published in the Journal of Chromatography B found that while TB-500 (Ac-LKKTETQ) did not enhance wound healing activity, its metabolite Ac-LKKTE did . This result indicates that reported wound-healing activity attributed to TB-500 might result from its active metabolite rather than the parent fragment itself . This finding highlights the importance of considering metabolic pathways in TB-500 research design.

Why Choose Liaocheng Yixin Company?

When sourcing tb-500 thymosin beta 4 5mg for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. Independent testing confirms purity exceeding 99% . Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC 

• Appearance: White lyophilized powder 

• Solubility: H2O: 247.5 mg/mL (278.4 mM) 

• Storage: Powder: -20°C for up to 3 years; In solvent: -80°C for up to 1 year 

• Form: Lyophilized powder for research use

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification (>99%)

4. Mass Spectrometry for molecular weight confirmation

5. Identity confirmation by IR 

6. Packaged in sterile conditions for research use

7. tb-500 thymosin beta 4 5mg for research

When you need premium tb-500 thymosin beta 4 5mg for research for your tissue repair, angiogenesis, or regenerative studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.