HGH Fragment 176-191

HGH Fragment 176-191 – Premium Research Peptide

Welcome to Liaocheng Yixin Company, your trusted source for premium hgh fragment 176-191 for sale. As a specialized peptide synthesis manufacturer operating from our facility at No. 9 Lushan Road, Dongcheng Street, Liaocheng Economic and Technological Development Zone, Shandong Province, we provide high-quality research compounds for the global scientific community.

HGH Fragment 176-191 represents a highly specific 16-amino-acid segment derived from the C-terminal region of the human growth hormone (hGH) molecule . This peptide has attracted increasing attention across molecular biology, cellular energetics, metabolic regulation, and biochemical signaling domains. Our hgh fragment 176-191 for sale offers researchers a reliable, high-purity compound for their investigative work.

What is HGH Fragment 176-191?

HGH Fragment 176-191 (also known as AOD-9604) is a synthetic peptide corresponding to residues 176 through 191 of human growth hormone . Unlike full-length hGH, this fragment is structurally distinct from the parent hormone and is believed to selectively target pathways involved in lipid metabolism without significantly impacting systemic growth hormone activity .

Key identifiers:

• CAS Number: 66004-57-7 (free base) 

• Molecular Formula: C78H123N23O23S2 

• Molecular Weight: 1815.09 g/mol 

• Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (Disulfide bridge Cys7-Cys14) 

• Synonyms: AOD-9604, Frag 176-191, HGH Frag 176-191

Mechanism of Action in Research

What makes HGH Fragment 176-191 especially intriguing is its selective profile. Research indicates that this fragment may exhibit metabolic-oriented properties without stimulating the wider somatotropic activities typically linked with full-length GH .

Key research observations:

• Lipid metabolism focus: Investigations purport that the peptide may promote lipolysis (fat breakdown) while inhibiting lipogenesis (fat formation) . One source describes it as “regulating fat metabolism but without the adverse effects on blood sugar or growth” .

• Selective pathway engagement: Unlike growth hormone, AOD-9604 does not activate GH receptors and was designed to minimize negative endocrine effects . It appears to behave in a more targeted fashion, potentially interacting with intracellular pathways related to cAMP signaling .

• Cellular signaling research: It has been hypothesized that the peptide might support signaling proteins associated with energy stress responses, including AMP-activated protein kinase (AMPK) .

• Receptor binding studies: HGH Fragment 176-191 has been shown to bind with high affinity to Ki-67, MiB protein, and estrogen receptor .

Applications in Scientific Research

HGH Fragment 176-191 has been the subject of numerous peer-reviewed studies across multiple research domains:

Metabolic Research

One of the most extensively explored domains for this peptide is its possible impact on lipid metabolism. Research has focused on its potential to support lipolytic pathways and influence energy expenditure, mitochondrial activity, and fuel utilisation . A study published in the Journal of Endocrinology found that GH fragment 176-191 increased lipid oxidation in test systems and did not stimulate IGF-1 or GH signaling like full GH .

Cancer Research

An emerging research direction involves the peptide’s potential role in oncology. A 2022 study published in Drug Design, Development and Therapy evaluated the anticancer efficacy of Chitosan nanoparticles loaded with HGH Fragment 176-191 plus doxorubicin . The study concluded that this dual-loading strategy demonstrated greater anti-proliferative activity against a breast cancer cell line (MCF-7) than doxorubicin alone .

Cartilage and Tissue Research

Some exploratory trials have studied the peptide’s potential role in cartilage regeneration, post-injury recovery, and inflammation modulation . Research indicates that AOD-9604 may influence chondrocyte activity and matrix synthesis, prompting hypotheses that the fragment might influence chondrogenic pathways independently of the full somatotropic axis .

Why Choose Liaocheng Yixin Company?

When sourcing hgh fragment 176-191 for sale, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards, ensuring every product meets research-grade specifications.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. Certificates of Analysis confirming purity levels exceeding 99% are available upon request. Our quality standards align with industry norms where typical HPLC purity exceeds 95% .

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• Appearance: White to off-white lyophilized powder

• Storage: Store powder at -20°C in a sealed container, protected from light and moisture

• Form: Lyophilized powder for research use

Quality Assurance & Testing

Every batch of hgh fragment 176-191 for sale undergoes comprehensive quality control:

1. Synthesis by experienced chemists using advanced solid-phase techniques

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. Packaged in sterile conditions for research use

When you need premium hgh fragment 176-191 for sale for your metabolic, cancer, or tissue research applications, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.