HGH 191AA (Somatropin) – Premium Research Grade Growth Hormone

Welcome to Liaocheng Yixin Company, your trusted source for premium hgh 191aa somatropin for research. As a licensed peptide synthesis manufacturer operating from our facility in Shandong Province, China, we provide high-quality research compounds for the global scientific community.

HGH 191AA (Somatropin) is recombinant human growth hormone with the full 191 amino acid sequence identical to endogenous pituitary-derived GH . It is produced via recombinant DNA technology, providing a research-grade supply of the same somatropin molecule characterized in the scientific literature . Our hgh 191aa somatropin for research offers a reliable, high-purity compound for growth hormone receptor, IGF-1 axis, and metabolic pathway studies.

What is HGH 191AA (Somatropin)?

Somatropin is a recombinant human growth hormone consisting of 191 amino acids, structurally aligned with endogenous pituitary growth hormone . It has a molecular weight of approximately 22.1 kDa and contains two disulfide bonds essential for its correct three-dimensional structure and receptor binding .

Key identifiers:

• CAS Number: 12629-01-5 

• Molecular Weight: ~22.1 kDa 

• Amino Acid Length: 191 amino acids 

• Synonyms: Somatropin, Recombinant Human Growth Hormone

• Purity: ≥99% verified by HPLC

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Mechanism of Action in Research

HGH 191AA (Somatropin) exerts its effects through a well-characterized mechanism that has been extensively studied in research settings .

Growth Hormone Receptor (GHR) Activation

Somatropin binds directly to the growth hormone receptor (GHR), a class I cytokine receptor, activating intracellular signaling cascades including the JAK2/STAT5 pathway . This leads to the regulation of gene transcription involved in growth, metabolism, and cellular proliferation.

IGF-1 Axis Activation

A key consequence of GHR activation is the stimulation of hepatic IGF-1 production. This pathway serves as a primary mediator of GH’s anabolic and metabolic effects . In research contexts, IGF-1 elevation is a direct marker of somatropin activity .

Physiological Effects in Research

As a direct receptor agonist, somatropin provides exogenous GH independent of pituitary function . This distinguishes it from GH secretagogues (e.g., GHRP-6, Ipamorelin), which stimulate endogenous GH release through the hypothalamic-pituitary axis. In research, somatropin is of interest for studies involving growth hormone receptor binding, downstream signaling pathways, and regulation of IGF-1 in cellular and preclinical models .

Research Applications

GH Receptor and IGF-1 Axis Research

• Investigating GHR binding kinetics and signal transduction pathways

• Studying JAK2/STAT5 and PI3K/AKT signaling cascades

• Examining IGF-1 mediated transcriptional regulation and anabolic effects

Metabolic and Endocrine Research

• Lipid metabolism and lipolysis studies

• Insulin sensitivity and glucose homeostasis research

• Nitrogen balance and protein synthesis investigations

Bioassay and Analytical Method Development

• Immunoassay development and validation

• Potency testing and biomarker assay research

• Stability and degradation profiling under defined experimental conditions

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Comparative Studies

• In vitro and in vivo receptor activation studies

• Comparisons with GH secretagogues and other growth factors

Why Choose Liaocheng Yixin Company?

When sourcing hgh 191aa somatropin for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards, adhering to rigorous protocols for recombinant peptide synthesis.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC and mass spectrometry. Our HGH 191AA meets ≥99% purity standards. Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• CAS Number: 12629-01-5

• hgh 191aa somatropin for research

• Molecular Weight: ~22.1 kDa

• Amino Acid Sequence: 191 amino acids, identical to endogenous pituitary GH 

• Appearance: White lyophilized powder

• Storage: Store powder at -20°C in a sealed, desiccated container, protected from light and moisture. Lyophilized HGH is stable at 2-8°C; reconstituted solution should be refrigerated and used within a few weeks .

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis in controlled expression systems

2. Purification via preparative HPLC

3. hgh 191aa somatropin for research

4. Analysis using HPLC and mass spectrometry for purity verification

5. Sequence confirmation to ensure correct amino acid composition 

6. Packaged under sterile conditions for research use

Important Research Considerations

Distinction from GH Fragments

HGH 191AA (Somatropin) is the full-length growth hormone molecule. It is distinctly different from the HGH Fragment 176-191 (AOD-9604), which is a 16-amino-acid C-terminal fragment that does not activate the GH receptor and does not elevate IGF-1 .

Storage and Stability

• Lyophilized HGH is stable at room temperature for limited periods but should be refrigerated at 2-8°C for long-term storage 

• Reconstituted solution must be refrigerated and used within a few weeks

• Heat, repeated freeze-thaw cycles, and vigorous shaking promote aggregation and denaturation 

Regulatory Status

• Human growth hormone (somatropin) is a Schedule III controlled substance in the United States 

• Listed on the WADA Prohibited List under S2 Peptide Hormones, Growth Factors, Related Substances and Mimetics 

• This product is strictly for research use only

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FAQ Section

: What is HGH 191AA (Somatropin)?

A: HGH 191AA (Somatropin) is recombinant human growth hormone identical in sequence to endogenous pituitary GH . It is produced via recombinant DNA technology and consists of the full 191 amino acid sequence.

: What is the difference between HGH 191AA and HGH Fragment 176-191?

A: HGH 191AA is the full-length growth hormone molecule that activates the GH receptor and elevates IGF-1. HGH Fragment 176-191 (AOD-9604) is a 16-amino-acid C-terminal fragment that does not activate GHR or raise IGF-1 .

: What research applications use HGH 191AA?

A: HGH 191AA is used in GH receptor and IGF-1 axis research, metabolic and endocrine studies, bioassay development, and comparative studies with other growth factors and secretagogues.

: How should HGH 191AA be stored?

A: Lyophilized powder should be stored at -20°C in a sealed, desiccated container. Reconstituted solution should be refrigerated at 2-8°C and used within a few weeks. Avoid repeated freeze-thaw cycles .

: What purity level can I expect?

A: All batches are tested to ensure ≥99% purity by HPLC analysis. Certificates of Analysis are available upon request.

: Is this product for human use?

A: No. Our HGH 191AA is manufactured strictly for research use only (RUO). It is not intended for human consumption or clinical applications .

When you need premium hgh 191aa somatropin for research for your GH receptor, IGF-1 axis, or metabolic studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.