IGF-1 LR3 Research Material Manufacturing

Welcome to Liaocheng Yixin Company, your trusted source for premium igf-1 lr3 peptide for research. As a licensed peptide synthesis manufacturer operating from our facility in Shandong Province, China, we provide high-quality research compounds for the global scientific community. igf-1 lr3 peptide for research

IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a recombinant analog of human IGF-1 specifically engineered for enhanced biological potency and stability . It contains the complete IGF-1 sequence with two key modifications: an Arginine substitution for Glutamic acid at position 3, and a 13-amino-acid N-terminal extension peptide, resulting in a single-chain polypeptide of 83 amino acids with a molecular weight of approximately 9.1 kDa . Our igf-1 lr3 peptide for research offers a reliable, high-purity compound for cell biology, stem cell, and tissue regeneration studies.  igf-1 lr3 peptide for research

What is IGF-1 LR3?

IGF-1 LR3 is a recombinant analog of human IGF-1 designed for mammalian cell culture and research applications. The structural modifications reduce the peptide’s affinity for IGF-binding proteins (IGFBPs)—approximately 1000-fold lower than native IGF-1 —resulting in an extended half-life and significantly higher biological potency . This makes it ideal for both research and large-scale culturing applications .

Key identifiers:

• CAS Number: 946870-92-4 

• Molecular Weight: ~9.1 kDa 

• Amino Acid Length: 83 amino acids 

• Synonyms: Long R3 IGF-1, LR3 IGF, IGF LR3, LArg3 IGF-1 

• Purity: ≥99% verified by HPLC

• igf-1 lr3 peptide for research

Mechanism of Action in Research

Reduced Binding Protein Affinity

The key distinction of IGF-1 LR3 is its extremely low affinity for the six known IGF-binding proteins (IGFBPs)—approximately 1000-fold lower than native IGF-1 . This means the peptide is not sequestered by binding proteins in culture media or biological fluids, making it more bioavailable for receptor activation .

IGF-1 Receptor Activation

IGF-1 LR3 binds to the IGF-1 receptor (IGF1R), a receptor tyrosine kinase homologous to the insulin receptor. This binding induces signaling within the cell by activating the Akt signaling pathway, which stimulates cell growth, proliferation, and inhibits apoptosis . It is one of the most potent activators of this pathway .

Enhanced Biological Potency

Due to its poor association with IGFBPs, LR3IGF-I has been shown to be 5-10 fold more potent than native IGF-I in cultured myoblasts and six-fold more potent in growth-promoting effects in vivo . Even when administered by injection rather than continuous infusion, LR3 IGF-I retains superior potency to IGF-I for several actions . It has demonstrated marked increases in body weight, nitrogen retention, and food conversion efficiency in research models . igf-1 lr3 peptide for research

Scientific Research Applications

Stem Cell Research and Cell Culture

IGF-1 LR3 is ideal for stem cell research and cell manufacturing applications, including cells of the ectoderm lineage (oligodendrocytes, motor neurons) and mesoderm lineage (osteocytes, chondrocytes, and muscle cells) . It can be used to substitute insulin for the maintenance of human pluripotent stem cells .

Muscle and Skeletal Tissue Research

The peptide supports the proliferation and survival of muscle, bone, and cartilage tissue . Research has demonstrated effects on muscle protein synthesis, cell proliferation, and tissue regeneration.

Reproductive Research

Studies have shown that LR3IGF-1 administration can further increase the ovulation rate induced by gonadotropins in rat models, indicating a physiological role in folliculogenesis and reproductive endocrinology .

Research Specifications

Biological Activity

• ED50 (cell proliferation assay): ≤ 2.0 ng/mL, corresponding to a specific activity of ≥ 5 × 10⁵ units/mg 

• ED50 (MCF-7 cells): ~0.3-1.5 ng/mL 

• Specific Activity: > 6.7 × 10⁵ IU/mg in serum-free cell proliferation assay 

• igf-1 lr3 peptide for research

Amino Acid Sequence
MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA 

Why Choose Liaocheng Yixin Company?

When sourcing igf-1 lr3 peptide for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards and follows rigorous protocols for recombinant protein production.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC and SDS-PAGE analysis. Our IGF-1 LR3 meets ≥99% purity standards. Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• CAS Number: 946870-92-4

• Molecular Weight: ~9.1 kDa

• Appearance: Lyophilized powder

• igf-1 lr3 peptide for research

• pH: 6.5-7.5 

• Endotoxin: <5 EU/mg 

• Storage: Store powder at ≤ -20°C . Reconstituted solution can be stored at 2-8°C for 2-7 days and at -20°C for up to 3 months 

• Form: Lyophilized powder for research use

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis in expression systems (E. coli) following cGMP protocols 

2. Purification via chromatography

3. Analysis using SDS-PAGE and HPLC for purity verification (>99%)

4. Mass Spectrometry for molecular weight confirmation

5. Endotoxin testing to ensure low endotoxin levels (<0.1 EU/µg) 

6. Packaged under sterile conditions for research use

: What is IGF-1 LR3 and how does it work in research?

A: IGF-1 LR3 is a recombinant analog of human IGF-1 with two key modifications: an Arginine substitution at position 3 and a 13-amino-acid N-terminal extension . It has approximately 1000-fold lower affinity for IGF binding proteins than native IGF-1, resulting in enhanced bioavailability and biological potency . It activates the Akt signaling pathway to stimulate cell growth, proliferation, and inhibit apoptosis .Q: What are the key research applications for IGF-1 LR3?

A: IGF-1 LR3 is used in stem cell research and cell culture, muscle and skeletal tissue research, and reproductive research models .

: Is IGF-1 LR3 the same as MGF (IGF-1Ec)?

A: No. IGF-1 LR3 is a full-length IGF-1 analog. MGF (Mechano Growth Factor, IGF-1Ec) is a splice variant of IGF-1 with different structural and signaling properties .

: What purity level can I expect?

A: All batches are tested to ensure ≥99% purity by HPLC analysis. Certificates of Analysis are available upon request.

: Is this product for human use?

A: No. Our IGF-1 LR3 is manufactured strictly for research use only (RUO). It is not intended for human consumption or clinical applications .

When you need premium igf-1 lr3 peptide for research for your cell biology, stem cell, or tissue regeneration studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust. igf-1 lr3 peptide for research