MGF IGF-1 EC (5mg) – Premium Research Peptide for Muscle & Tissue Studies

welcome to Liaocheng Yixin Company, your trusted source for premium mgf igf-1 ec 5mg for research. As a specialized peptide synthesis manufacturer operating from our facility at No. 9 Lushan Road, Dongcheng Street, Liaocheng Economic and Technological Development Zone, Shandong Province, we provide high-quality research compounds for the global scientific community.

MGF (Mechano Growth Factor), also known as IGF-1Ec, is a splice variant of the Insulin-like Growth Factor-1 (IGF-1) gene that is produced in response to mechanical stress or muscle damage . It features a unique E-domain that sets it apart from other IGF-1 isoforms, conferring specialized activity in muscle repair and regeneration . Our mgf igf-1 ec 5mg for research offers investigators a reliable, high-purity compound for muscle physiology, tissue repair, and regenerative studies.

What is MGF IGF-1 EC?

MGF (IGF-1Ec) is a 24-amino-acid peptide derived from the E-domain of the Mechano Growth Factor isoform of IGF-1 . It contains a unique 49-base pair insert in humans that causes a reading frame shift during gene splicing, producing a distinct mature isoform with specialized biological activity .

Key identifiers:

• CAS Number: 62031-54-3 

• Molecular Formula: C₁₂₁H₂₀₀N₄₂O₃₉ 

• Molecular Weight: 2867.21 g/mol 

• Sequence: H-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys-OH (YQPPSTNKNTKSQRRKGSTFEERK) 

• Synonyms: IGF-1Ec, Mechano Growth Factor, MGF-E peptide 

• Purity: ≥99% verified by HPLC 

Mechanism of Action in Research

Myoblast Proliferation and Fusion

MGF is distinct from mature IGF-1 in that its primary function is to stimulate myoblast proliferation rather than differentiation . Research shows that MGF-E peptide significantly increases the proliferative life span and delays senescence of satellite cells isolated from muscle tissue . MGF enhances satellite cell activation, proliferation, and fusion for muscle repair and maintenance .

Unique Receptor Pathway

Critically, MGF appears to act through a pathway independent of the classical IGF-1 receptor. Research demonstrates that MGF activates ERK1/2 phosphorylation but does not activate AKT phosphorylation . This pattern suggests that synthetic MGF E-peptide activity is mediated via a different, as-yet-unidentified receptor molecule . Blocking the IGF-1 receptor with a specific antibody does not inhibit MGF function .

Distinctive Signaling Pattern

Unlike mature IGF-1, which promotes differentiation via the PI3K-Akt pathway, MGF activates the Raf-MEK-ERK pathway, which is associated with myoblast proliferation . This unique signaling profile makes MGF a valuable tool for dissecting muscle regeneration mechanisms .

Scientific Research Applications

Muscle Regeneration Studies

MGF is widely used to examine processes governing skeletal muscle regeneration and hypertrophy . The peptide demonstrates marked ability to enhance satellite cell activation, proliferation, and fusion . However, it’s important to note that MGF-E peptide significantly increases proliferative life span in satellite cells from neonatal and young adult muscle, but this effect was not observed in old adult muscle .

Tissue Engineering and Repair Research

In basic research settings, MGF is employed to study muscle plasticity at the cellular and molecular levels . Experimental application in cultured myoblasts enables detailed analysis of regenerative pathways and supports tissue engineering research .

Cellular Adaptation Models

MGF is expressed following mechanical overload or injury, making it an important agent for modeling cellular adaptation to environmental stressors . Scientists use synthetic MGF to mimic effects of mechanical strain, investigating cytoskeletal remodeling and cellular proliferation .

Cancer Research Applications

Recent studies have investigated MGF (IGF-1Ec) in oncology contexts. IGF-1Ec may act independently of the classical IGF-1 receptor pathway and potentially contribute to aggressive tumor behavior . Ongoing research is examining MGF levels as potential biomarkers in solid tumors .

Why Choose Liaocheng Yixin Company?

When sourcing mgf igf-1 ec 5mg for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. Our MGF IGF-1 EC meets ≥99% purity standards . Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC 

• Appearance: White lyophilized powder 

• Solubility: Soluble in bacteriostatic water 

• Storage: Store powder at -20°C in a sealed container, protected from light and moisture 

• Form: Lyophilized powder for research use

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. Packaged in sterile conditions for research use

When you need premium mgf igf-1 ec 5mg for research for your muscle physiology, tissue regeneration, or cellular signaling studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.