Melanotan 2 (10mg) – Premium Research Peptide for Melanocortin Receptor Studies

Welcome to Liaocheng Yixin Company, your trusted source for premium melanotan 2 10mg for research. As a specialized peptide synthesis manufacturer operating from our facility in Shandong Province, China, we provide high-quality research compounds for the global scientific community.

Melanotan 2 (MT-II) is a synthetic cyclic peptide analog of alpha-melanocyte-stimulating hormone (α-MSH) developed at the University of Arizona in the 1990s as a more potent and stable alternative to earlier melanocortin peptides . Unlike the linear Melanotan 1 (afamelanotide), MT-II features a cyclic structure that enhances stability and receptor affinity . This structural modification makes MT-II a powerful research tool for investigating the melanocortin receptor system. Our melanotan 2 10mg for research offers investigators a reliable, high-purity compound for studying MC1R-mediated pigmentation and the broader systemic effects mediated by MC3R and MC4R.

What is Melanotan 2?

Melanotan 2 (CAS: 121062-08-6) is a cyclic heptapeptide analog of α-MSH with the sequence Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-NH₂ . Its cyclic structure distinguishes it from the linear Melanotan 1, providing enhanced stability and broader receptor activity.

Key Identifiers:

• CAS Number: 121062-08-6 

• Molecular Formula: C₅₀H₆₉N₁₅O₉ 

• Molecular Weight: ~1,024.18 g/mol 

• Sequence: Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-NH₂ 

• Synonyms: MT-II, MT-2, Melanotan II

• Purity: ≥98% verified by HPLC 

Mechanism of Action in Research

Melanotan 2 functions as a non-selective agonist across multiple melanocortin receptor subtypes, making it a unique tool for studying the entire melanocortin family .

Pan-Melanocortin Receptor Agonism

MT-II’s key research value lies in its broad receptor activity profile. It activates MC1R, MC3R, MC4R, and MC5R with varying affinities :

This non-selectivity makes MT-II valuable for studying the simultaneous activation of multiple melanocortin receptors in in vitro and animal models, providing a comprehensive view of how these receptors interact and influence diverse physiological systems .

Key Research-Relevant Effects

• MC1R-Mediated Melanogenesis: Activates the cAMP signaling pathway in melanocytes, increasing eumelanin production and pigmentation 

• MC4R-Mediated Systemic Effects: Binds central MC3R and MC4R receptors in the hypothalamus, influencing appetite regulation, energy expenditure, and neuroendocrine pathways 

• Neuroendocrine Modulation: Central receptor activation influences oxytocin and dopamine release, making it relevant for behavioral and neuroendocrine research 

Distinction Between Melanotan 1 and Melanotan 2

Understanding the differences between these two peptides is essential for proper research application:

Melanotan 1 is the peptide of choice for studying melanin synthesis and photoprotection. Melanotan 2 broadens the research landscape by engaging multiple melanocortin receptors involved in metabolism, neuroendocrine signaling, and behavioral regulation . Its non-selectivity is what distinguishes MT-II from all other melanocortin molecules that have received marketing authorization .

Scientific Research Applications

Melanotan 2 is a well-established research tool with documented applications across multiple domains:

Melanocortin Receptor Signaling Studies
MT-II serves as the canonical reference agonist for structure-activity relationship studies dissecting the molecular determinants of melanocortin receptor subtype selectivity . Its well-characterized Ki profile across all melanocortin receptors provides a quantitative baseline against which novel synthetic analogs can be benchmarked .

Metabolic and Obesity Research
Through its activity at MC3R and MC4R, MT-II has become a focus of metabolic research . Studies suggest that MC4R activation may influence appetite regulation, thermogenesis, and fat utilization, offering insight into how melanocortin pathways contribute to energy homeostasis .

Neuroendocrine and Sexual Function Studies
MT-II is frequently studied in neuroendocrine models because of its activity at central nervous system melanocortin receptors, particularly MC3R and MC4R . Activation of these receptors has been associated with modulation of sexual arousal and stress responses, making them key targets in behavioral neuroendocrine research . This line of research contributed directly to the development of PT-141 (bremelanotide), a more selective MC4R agonist designed specifically for sexual dysfunction studies .

Photoprotection and Pigmentation Research
MT-II is also investigated for its ability to induce a rapid melanin response, making it a tool for studying melanocortin-mediated tanning .

Important Research Considerations

Regulatory Status
MT-II is NOT FDA-approved for any indication and is not legally marketed for human use in the United States, the United Kingdom, or the European Union . It is available exclusively as a research compound for in-vitro laboratory studies . Products sold online as Melanotan-II are unregulated and may contain contaminants, incorrect dosing, or misidentified compounds .

Documented Adverse Effects in Case Literature
MT-II has been associated with documented adverse events in published case reports:

• Nausea, facial flushing, and vomiting 

• Spontaneous penile erection and priapism (urological emergency) 

• Nevi darkening and new melanocytic nevi formation 

• Multiple independent case reports of melanoma (2011-2025) 

• Rhabdomyolysis and renal infarction 

Safe Handling
MT-II is provided as a lyophilized powder and should be stored desiccated below -18°C . Upon reconstitution, it should be stored at 4°C for 2-21 days and below -18°C for future use, avoiding repeated freeze-thaw cycles .

Why Choose Liaocheng Yixin Company?

When sourcing melanotan 2 10mg for research, quality and reliability are paramount. Here’s why researchers trust us:

Verified Purity Standards
Every batch undergoes rigorous testing using HPLC analysis. Our Melanotan 2 meets ≥98-99% purity standards . Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥98% verified by HPLC 

• Appearance: White lyophilized powder 

• Storage: Store powder desiccated below -18°C 

• Reconstitution: Use sterile bacteriostatic water or sodium chloride 

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification (≥98%)

4. Mass Spectrometry for molecular weight confirmation

5. Packaged in sterile, light-protected conditions for research use

When you need premium melanotan 2 10mg for research for your melanocortin receptor, metabolic, or neuroendocrine studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.