Syn-AKE (200mg) – Premium Synthetic Tripeptide for Research

Welcome to Liaocheng Yixin Company, your trusted source for premium syn-ake 200mg peptide for research. As a specialized peptide synthesis manufacturer operating from our facility at No. 9 Lushan Road, Dongcheng Street, Liaocheng Economic and Technological Development Zone, Shandong Province, we provide high-quality research compounds for the global scientific community. syn-ake 200mg peptide for research

Syn-AKE is a synthetic tripeptide with the sequence beta-Ala-Pro-Dab-NHBzl (CAS: 823202-99-9) that functions as a reversible antagonist of the muscular nicotinic acetylcholine receptor (mnAChR) . Developed by Pentapharm Ltd. (now DSM-Firmenich), it was designed as a simplified structural mimetic of Waglerin-1—a 22-amino-acid peptide found in the venom of the temple viper (Tropidolaemus wagleri) . Our syn-ake 200mg peptide for research offers investigators a reliable, high-purity compound for neuromuscular signaling, receptor pharmacology, and biochemical research applications.

What is Syn-AKE?

Syn-AKE (INCI: Dipeptide Diaminobutyroyl Benzylamide Diacetate) is a synthetic peptide inspired by the molecular structure of Waglerin-1, a venom peptide known for its interaction with nicotinic acetylcholine receptors . Unlike the natural venom peptide, Syn-AKE is fully synthetic, vegan-friendly, and significantly smaller—its molecular weight of approximately 495 Da compared to the much larger Waglerin-1 .

Key identifiers:

• Sequence: beta-Ala-Pro-Dab-NHBzl (beta-alanyl-L-prolyl-3-aminomethyl-L-alanine benzyl amide acetic acid) 

• Molecular Formula: C23H37N5O7 

• Molecular Weight: 495.57 g/mol 

• Synonyms: Tripeptide-3, Syn-Ake acetate, Acetyl Octapeptide-3 (related family), SYN®-AKE

• Purity: ≥99% verified by HPLC 

• syn-ake 200mg peptide for research

Mechanism of Action in Research

Syn-AKE operates through a well-characterized mechanism at the neuromuscular junction, making it valuable for receptor and signaling research .

Nicotinic Acetylcholine Receptor Antagonism

Syn-AKE is a reversible antagonist at the muscular nicotinic acetylcholine receptor (mnAChR) . When acetylcholine binds to these receptors at the neuromuscular junction, it triggers sodium ion influx and muscle contraction. By occupying receptor sites, Syn-AKE prevents acetylcholine binding, keeping sodium channels closed and reducing the frequency of muscle contractions .syn-ake 200mg peptide for research

Key research findings:

• 82% reduction in the frequency of innervated muscle cell contractions after 2 hours of exposure in experimental settings 

• Up to 52% reduction in wrinkle appearance in human volunteer studies with 28-day twice-daily application 

• 62% reduction in muscle contractile response to electrical stimulation compared to untreated controls in vitro 

• In silico studies indicate stable binding to MMP-13 and SIRT1 receptors with docking scores of -9.32 kcal/mol, suggesting potential for broader anti-aging research applications 

Receptor Selectivity

Syn-AKE was specifically designed to lack the activity of Waglerin-1 on GABA receptors in the brain, focusing its action on peripheral neuromuscular receptors . This selectivity makes it a cleaner research tool for studying neuromuscular signaling pathways without central nervous system effects.

Scientific Research Applications

Syn-AKE has been studied across multiple research domains:

Neuromuscular Junction Research

The peptide serves as a model compound for studying nicotinic acetylcholine receptor pharmacology, structure-activity relationships, and receptor-ligand interactions . Its reversible antagonism makes it particularly useful for kinetic studies of receptor binding and dissociation.

Cosmetic Ingredient Research

Syn-AKE is the most widely used synthetic peptide in cosmetic research. A 2025 market analysis of 245 cosmetic products found that Syn-AKE (INCI: Dipeptide Diaminobutyroyl Benzylamide Diacetate) was present in 81% of analyzed products, while natural snake venom appeared in only 13% . This widespread adoption makes it a valuable reference compound in formulation research.syn-ake 200mg peptide for research

Skin Aging and Expression Line Studies

Research has investigated Syn-AKE’s effects on expression lines and skin texture. Human volunteer studies demonstrated visible improvements in wrinkle depth after 28 days of application .

Anti-Aging Research

In silico studies published in the Journal of Biomolecular Structure & Dynamics demonstrated stable binding of Syn-AKE to receptors involved in aging processes including MMP-13 and SIRT1 . It also showed concentration-dependent radical-scavenging activity in antioxidant assays.

Why Choose Liaocheng Yixin Company?

When sourcing syn-ake 200mg peptide for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. Our Syn-AKE meets ≥99% purity standards. Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC 

• Molecular Weight: 495.57 g/mol 

• Appearance: Raw powder form

• Storage: Store powder at -20°C in a sealed, desiccated container, protected from light and moisture

• Form: Raw powder for research use, not for reconstitution 

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using optimized peptide synthesis protocols 

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. Packaged under appropriate conditions for research use

6. syn-ake 200mg peptide for research

: What is Syn-AKE and how does it work in research?

A: Syn-AKE is a synthetic tripeptide (beta-Ala-Pro-Dab-NHBzl) that functions as a reversible antagonist of the muscular nicotinic acetylcholine receptor . It reduces the frequency of muscle contractions by competing with acetylcholine at the neuromuscular junction .

: Is Syn-AKE derived from real snake venom?

A: No. Syn-AKE is fully synthetic and produced in a laboratory—no animal-derived material is required . It is a simplified structural mimetic of Waglerin-1, a peptide found in temple viper venom .

: What are the key research applications for Syn-AKE?

A: Syn-AKE is used in neuromuscular junction receptor research, skin aging and expression line research, antioxidant studies, receptor pharmacology, and cosmetic formulation research .

: What purity level can I expect?

A: All batches are tested to ensure ≥99% purity by HPLC analysis. Certificates of Analysis are available upon request .

: Is this product for human use?

A: No. Our Syn-AKE is manufactured strictly for research use only (RUO). It is not intended for human consumption, injection, or clinical applications .

When you need premium syn-ake 200mg peptide for research for your neuromuscular, receptor pharmacology, or cosmetic research studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust. syn-ake 200mg peptide for research