SNAP-8 (200mg) – Premium Octapeptide for Cosmetic and Biochemical Research

Welcome to Liaocheng Yixin Company, your trusted source for premium snap-8 200mg peptide for research. As a specialized peptide synthesis manufacturer operating from our facility in Shandong Province, China, we provide high-quality research compounds for the global scientific community.

SNAP-8 (Acetyl Octapeptide-3) is a synthetic octapeptide derived from the N-terminal domain of the synaptosomal-associated protein of 25 kDa (SNAP-25), a central component of the SNARE (Soluble NSF Attachment Protein Receptor) complex . It functions as a competitive modulator within SNARE-mediated vesicular fusion processes, making it a valuable research tool for studying neurotransmitter release dynamics, cellular communication, and neuromolecular signaling . Our snap-8 200mg peptide for research offers investigators a reliable, high-purity compound for biochemical and cosmetic research applications. snap-8 200mg peptide for research 

What is SNAP-8?

SNAP-8 (Acetyl Octapeptide-3) is an octapeptide designed to mimic a functional motif of SNAP-25 . It represents an upgraded version of the well-known hexapeptide Argireline, with two additional amino acids (alanine and aspartic acid) at the C-terminus to enhance molecular stability and binding affinity .

Key identifiers:

• CAS Number: 868844-74-0 

• Molecular Formula: C41H70N16O16S 

• Molecular Weight: 1075.16 g/mol 

• Sequence: Ac-EEMQRRAD-NH2 (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2) 

• Synonyms: Acetyl Octapeptide-3, Acetyl Glutamyl Heptapeptide-3 

• Purity: ≥99% verified by HPLC

• snap-8 200mg peptide for research

Mechanism of Action in Research

SNAP-8 operates through a well-characterized mechanism that makes it valuable for biochemical and neuromolecular research .

SNARE Complex Modulation

The SNARE complex is a four-helical bundle essential for synaptic vesicle docking and fusion, comprising synaptobrevin (VAMP), syntaxin-1, and SNAP-25 . SNAP-8 mimics the N-terminal sequence of SNAP-25, allowing it to compete for binding sites within the SNARE complex .

Competitive Binding Properties

SNAP-8 binds to syntaxin with high affinity (Kd ≈ 0.8 µM) and synaptobrevin with moderate affinity (Kd ≈ 2.3 µM), occupying sites normally reserved for the N-terminal domain of SNAP-25 . This binding sterically hinders the formation of a functional SNARE complex, destabilizing the initial SNAREpin assembly .

Vesicular Fusion Modulation

The competitive interaction alters the kinetics of SNARE complex assembly, potentially slowing vesicular fusion events and modulating neurotransmitter-like release mechanisms . Research indicates that SNAP-8 analogs reduce the frequency of miniature excitatory postsynaptic currents (mEPSCs) by 35-45%, indicating suppressed spontaneous neurotransmitter release .snap-8 200mg peptide for research

Scientific Research Applications

SNAP-8 has been studied across multiple research domains .

Neurochemical Signaling Research

SNAP-8 is utilized in experimental frameworks to explore how vesicle release frequency, timing, and amplitude are regulated . By introducing controlled perturbation into the SNARE system, researchers may observe shifts in signaling patterns that reveal underlying regulatory principles .

Cellular Communication and Secretion Models

Vesicular trafficking plays a critical role in cellular communication, including hormone-like secretion and intracellular transport. SNAP-8 has been explored as a tool to probe these processes in controlled laboratory settings .

Analytical Method Development

SNAP-8 has been used in the development of analytical methods for quality control applications. Studies have established LC-MS/MS methods with good linearity (r ≥ 0.9971) and a limit of quantification of 0.0125 ng/mL, demonstrating suitability for quantification in patch products .

Comparative Efficacy Research

Research indicates that SNAP-8 demonstrates 30% higher potency in SNARE complex disruption compared to its precursor peptide Argireline due to its extended amino acid sequence, which enhances structural complementarity .

Why Choose Liaocheng Yixin Company?

When sourcing snap-8 200mg peptide for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. Our SNAP-8 meets ≥99% purity standards . Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• Appearance: White to off-white lyophilized powder

• Storage: Store powder at -20°C in a sealed, desiccated container, protected from light and moisture 

• Form: Lyophilized powder for research use

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. Packaged in sterile conditions for research use

6. snap-8 200mg peptide for research

: What is SNAP-8 and how does it work in research?

A: SNAP-8 is a synthetic octapeptide derived from the N-terminal domain of SNAP-25 that functions as a competitive modulator of the SNARE complex, disrupting vesicular fusion and neurotransmitter release mechanisms .

: What are the key research applications for SNAP-8?

A: SNAP-8 is used in neurochemical signaling research, cellular communication studies, analytical method development, and comparative efficacy research for cosmetic peptides .

: How does SNAP-8 differ from Argireline?

A: SNAP-8 is an upgraded version of Argireline (Acetyl Hexapeptide-3) with two additional amino acids (alanine and aspartic acid) that enhance molecular stability and improve SNARE complex binding affinity . Research indicates SNAP-8 demonstrates 30% higher potency in SNARE complex disruption .

: What purity level can I expect?

A: All batches are tested to ensure ≥99% purity by HPLC analysis. Certificates of Analysis are available upon request .snap-8 200mg peptide for research

: Is this product for human use?

A: No. Our SNAP-8 is manufactured strictly for research use only (RUO). It is not intended for human consumption or clinical applications .

When you need premium snap-8 200mg peptide for research for your neurochemical, cellular communication, or cosmetic research studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.