Thymosin Alpha-1 (5mg) – Premium Research Grade Immunomodulatory Peptide

Welcome to Liaocheng Yixin Company, your trusted source for premium thymosin alpha-1 5mg for research. As a licensed peptide synthesis manufacturer operating from our facility in Shandong Province, China, we provide high-quality research compounds for the global scientific community.

Thymosin Alpha-1 (Tα1) is a highly conserved 28-amino-acid peptide initially isolated from the thymus gland. It functions as a potent immunomodulator, interacting with Toll-like receptors (TLRs) to enhance both innate and adaptive immune responses . Unlike direct immune stimulants, Tα1 acts through TLR-2, -3, -4, and -9 signaling pathways to promote T-cell differentiation, dendritic cell maturation, and cytokine production . When you buy thymosin alpha-1 for research, you gain access to a well-characterized tool for immunology, infectious disease, and oncology studies.   thymosin alpha-1 5mg for research

What is Thymosin Alpha-1?

Thymosin Alpha-1 is a synthetic 28-amino-acid peptide with the molecular formula C₁₂₉H₂₁₅N₃₃O₅₅ and a molecular weight of 3108.28 g/mol . It is a biological response modifier that has been studied in preclinical and clinical settings for its ability to restore immune function in immunocompromised states .

Key identifiers:

• CAS Number: 62304-98-7 

• Molecular Formula: C₁₂₉H₂₁₅N₃₃O₅₅

• Molecular Weight: 3108.28 g/mol 

•  thymosin alpha-1 5mg for research

• Synonyms: Tα1, Thymosin α-1, immune modulator peptide

• Purity: ≥99% verified by HPLC

Mechanism of Action in Research

Thymosin Alpha-1 exerts its effects through several well-characterized mechanisms that make it a valuable research tool:

Toll-Like Receptor Signaling

Tα1 has been shown to be a TLR-9 and TLR-2 agonist . It activates downstream IRF3 and NF-κB signal pathways, promoting the proliferation and activation of target immune cells. TLR2/NF-κB, TLR2/p38MAPK, and TLR7/MyD88 signaling pathways are activated to promote the production of various cytokines, enhancing both innate and adaptive immune responses .

Dendritic Cell Modulation

Tα1 promotes the expression of activation markers on dendritic cells and drives differentiation of naive T cells toward a Th1 phenotype . This mechanism explains why Tα1 has been studied across such a wide range of immunocompromised states—it restores the upstream decision-making capacity of the innate immune system to direct adaptive responses.

T-Cell and Cytokine Activation

Pharmacologic studies show that Tα1 enhances the immune system by stimulating cytokine secretion and enhancing T-cell function . It promotes CD4-expressed dendritic cell differentiation and enhances the up-regulated levels of mature markers induced by TNF-α .

Research Applications

Immunology and Immunosenescence Research

Aging is characterized by immune decline, primarily due to thymic involution. Tα1 has been shown to restore immune function by stimulating T-cell differentiation, enhancing thymic output, and modulating dendritic cell and macrophage activity in preclinical models . Research has demonstrated Tα1’s ability to improve vaccine response in elderly populations and mitigate immunosenescence .

Infectious Disease Research

Tα1 has been extensively studied in models of both acute and chronic viral, bacterial, and fungal infections . The most consistent evidence base is in chronic hepatitis B research, where randomized controlled trials have demonstrated virological response rates of 40.6% versus 9.4% in controls . Tα1 has also been investigated in severe sepsis models, with studies showing improvements in immune recovery markers such as monocyte HLA-DR expression .

Cancer Research

Tα1 has been explored as an add-on treatment alongside chemotherapy and checkpoint inhibitors . A 2022 study showed Tα1-Fc fusion protein displayed effective antitumor activity in tumor xenograft models by upregulating CD86 expression, secreting IFN-γ and IL-2, and increasing tumor-infiltrating CD4+ and CD8+ T cells . Ongoing clinical trials are evaluating Tα1 combined with anti-PD-1 monoclonal antibody in elderly patients with advanced melanoma . thymosin alpha-1 5mg for research

Important Research Considerations

Evidence Base

Tα1 has been studied in over 4,400 subjects enrolled in US, European, and Chinese clinical trials . It is approved in over 30 countries for viral hepatitis and other immunosuppressive conditions, though it is not FDA-approved in the United States . In early 2026, the FDA announced an advisory panel will review whether restricted peptides—including Tα1—should return to the Category 1 list of bulk substances .

Safety Profile

Past studies looking at the safety of Tα1 found the most common side effects were local irritation, discomfort, or redness at the injection site . Based on substantial evidence from clinical trials, Tα1 emerges as a well-tolerated and effective immune modulator .

Product Quality

Thymosin Alpha-1 is available as a sterile lyophilized powder. Reconstitution is typically performed with bacteriostatic water, with research protocols commonly using concentrations of 2.5-5.0 mg/mL depending on the intended dose and injection volume . Lyophilized vials should be stored at 2-8°C, protected from light, and should not be frozen .

Why Choose Liaocheng Yixin Company?

When sourcing thymosin alpha-1 5mg for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards, adhering to rigorous protocols for peptide synthesis.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. Our Thymosin Alpha-1 meets ≥99% purity standards, and we provide Certificates of Analysis with identity confirmation by mass spectrometry .

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• Molecular Weight: 3108.28 g/mol 

• CAS Number: 62304-98-7

•  thymosin alpha-1 5mg for research

• Appearance: White to off-white lyophilized powder 

• Storage: Store powder at 2-8°C in a sealed, desiccated container, protected from light. Do not freeze 

• Form: Lyophilized powder for research use

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification (>99%) 

4. Mass Spectrometry for molecular weight confirmation

5. Peptide content verification 

6. Packaged under sterile conditions for research use

7.  thymosin alpha-1 5mg for research

: What is Thymosin Alpha-1 and how does it work in research?

A: Thymosin Alpha-1 is a 28-amino-acid peptide that functions as a potent immunomodulator. It acts as a TLR-2, -3, -4, and -9 agonist, activating NF-κB and IRF3 signaling pathways to promote T-cell differentiation, dendritic cell maturation, and cytokine production .

: What research applications use Thymosin Alpha-1?

A: Tα1 is used in immunology research (T-cell differentiation, immunosenescence), infectious disease models (hepatitis, sepsis), cancer research (adjuvant therapy with checkpoint inhibitors), and vaccine enhancement studies .

: Is Thymosin Alpha-1 approved for human use?

A: Tα1 is approved in over 30 countries for viral hepatitis and other immunosuppressive conditions, but it is not FDA-approved in the United States. It is sold strictly for research use only .

: What purity level can I expect?

A: All batches are tested to ensure ≥99% purity by HPLC analysis. Certificates of Analysis with MS identity confirmation are available upon request .

: Is this product for human use?

A: No. Our Thymosin Alpha-1 is manufactured strictly for research use only (RUO). It is not intended for human consumption or clinical applications.

When you need premium thymosin alpha-1 5mg for research for your immunology, infectious disease, or oncology studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.