Pancragen (20mg) – Premium Research Tetrapeptide for Pancreatic & Metabolic Studies

Welcome to Liaocheng Yixin Company, your trusted source for premium pancragen 20mg for research. As a specialized peptide synthesis manufacturer operating from our facility in Shandong Province, China, we provide high-quality research compounds for the global scientific community.

Pancragen is a synthetic tetrapeptide bioregulator composed of the amino acid sequence Lys-Glu-Asp-Trp (KEDW) . It belongs to the Khavinson family of short peptide bioregulators and is specifically designed to target pancreatic tissue for investigation into beta-cell function, insulin regulation, and glycemic control . Our pancragen 20mg for research offers investigators a reliable, high-purity tool for metabolic, pancreatic, and age-related endocrine dysfunction studies.

What is Pancragen?

Pancragen is a synthetic tetrapeptide bioregulator with the sequence Lys-Glu-Asp-Trp (KEDW) . It was developed at the Saint Petersburg Institute of Bioregulation and Gerontology under Professor Vladimir Khavinson from fraction analysis of young, healthy pancreatic tissue extracts . Pancragen is the pancreas-specific member of the Khavinson peptide bioregulator family, alongside Epithalon (pineal gland), Thymalin (thymus), and other organ-targeting bioregulators .

Key Identifiers:

• Molecular Formula: C26H36N6O9 

• Molecular Weight: ~576.3 g/mol 

• Sequence: H-Lys-Glu-Asp-Trp-OH (KEDW); literature often uses C-terminal amide KEDW-NH2 

• Synonyms: Pancragen, KEDW, pancreatic peptide bioregulator 

• Purity: ≥99% verified by HPLC

Mechanism of Action in Research

Pancragen exerts its effects through epigenetic regulation of pancreatic gene expression:

Epigenetic Mechanism

Like other Khavinson peptides, Pancragen is proposed to interact directly with DNA in the minor groove of specific promoter sequences . This interaction modulates local chromatin architecture by influencing histone acetylation and methylation patterns, increasing the accessibility of pancreas-specific genes to their cognate transcription factors . Short peptides like Pancragen can penetrate cell nuclei and interact with DNA and histone proteins, regulating cell differentiation through epigenetic mechanisms .

Insulin Production Enhancement

Pancragen’s primary functional effect is enhanced insulin biosynthesis. By facilitating chromatin opening at the insulin gene locus, it enables increased binding of critical beta-cell transcription factors including PDX-1 and MafA . This results in elevated preproinsulin mRNA transcription, increased proinsulin processing, and ultimately greater insulin secretory capacity .

Pancreatic Cell Differentiation

Research demonstrates that Pancragen stimulates the expression of differentiation factors in both acinar cells (Pdx1, Ptf1a) and islet of Langerhans cells (Pdx1, Pax6, Pax4, Foxa2, Nkx2.2) . This tissue-specific stimulation was more pronounced in aged cultures, suggesting a geroprotective mechanism . The inducing effect of peptides on differentiation factor expression in aged cultures can serve as a mechanism of their geroprotective effect .

Scientific Research Applications

Pancragen has been studied across multiple research domains:

Diabetes & Glucose Metabolism Research

In a study on Wistar rats with experimental streptozotocin-induced diabetes, oral Pancragen produced a pronounced hypoglycemic effect during treatment . Intramuscular administration normalized the adhesion of mesenteric capillary endothelium, indicating homeostatic and endothelioprotective effects .

Age-Related Pancreatic Dysfunction Research

In a study on old female rhesus monkeys (20-25 years), Pancragen administration (50 μg/animal/day for 10 days, intramuscularly) markedly increased glucose “disappearance” rate, normalized plasma insulin and C-peptide dynamics in response to glucose administration . The recovering effect partially remained 3 weeks after discontinuation, suggesting sustained impact .

A separate primate study comparing Pancragen to glimepiride demonstrated that Pancragen produced a more moderate glucose-lowering effect but normalized insulin and C-peptide levels, suggesting recovery of physiological pancreatic function rather than forced insulin secretion . Pancragen was described as effective and safe for correcting age-related endocrine pancreatic dysfunction without delayed hypoglycemic effects .

Cellular Differentiation Research

In human embryonic pancreatic cell cultures, Pancragen stimulated expression of differentiation factors for both acinar cells (Pdx1, Ptf1a) and islet cells (Pdx1, Pax6, Pax4, Foxa2, Nkx2.2) in both young and aged cultures . This differentiation mechanism is identified as the basis for Pancragen’s anti-diabetic and anti-inflammatory research applications . Transcription factors regulating pancreatic cell differentiation are considered pharmacological targets for Pancragen, positioning it as an effective research tool in diabetes and pancreatitis models .

Why Choose Liaocheng Yixin Company?

When sourcing pancragen 20mg for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. Certificates of Analysis are available upon request. Typical purity exceeds 99% by HPLC .

Research-Grade Specifications

• Purity: ≥99% verified by HPLC 

• Appearance: White to off-white lyophilized powder 

• Solubility: Soluble in water and buffered aqueous solutions 

• Storage: Store powder at -20°C in a sealed container, protected from light and moisture 

•  pancragen 20mg for research

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. Packaged in sterile conditions for research use

6.  pancragen 20mg for research

When you need premium pancragen 20mg for research for your pancreatic, metabolic, or age-related endocrine dysfunction studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.