Pal-GHK (200mg) – Premium Palmitoyl Tripeptide-1 for Research

Welcome to Liaocheng Yixin Company, your trusted source for premium pal-ghk 200mg peptide for research. As a specialized peptide synthesis manufacturer operating from our facility in Shandong Province, China, we provide high-quality research compounds for the global scientific community.

Pal-GHK (Palmitoyl Tripeptide-1) is a synthetic lipopeptide consisting of the tripeptide Gly-His-Lys (GHK) conjugated to a palmitoyl fatty acid chain . This palmitoyl modification enhances lipophilicity and skin permeability, allowing it to penetrate the stratum corneum to reach the epidermal and dermal layers . As a well-characterized “signal peptide,” it can “tell” skin cells to produce more collagen and repair visible damage . Our pal-ghk 200mg peptide for research offers investigators a reliable, high-purity compound for advanced dermatological, extracellular matrix, and matrikine signaling studies.

• pal-ghk 200mg peptide for research

What is Pal-GHK?

Pal-GHK is a synthetic peptide in which the GHK tripeptide has been linked to a palmitoyl fatty acid molecule . It is also known as Palmitoyl Tripeptide-1, Palmitoyl Oligopeptide, or C16-GHK . This palmitoyl modification makes the peptide more fat-soluble, which may increase its cell penetration and absorption . As a core component of the widely studied Matrixyl 3000® complex, Pal-GHK is one of the most commercially proven anti-aging peptide complexes with substantial clinical evidence .

Key identifiers:

• CAS Number: 147732-56-7 

• Molecular Formula: C30H54N6O5 

• Molecular Weight: 578.79 g/mol 

• Synonyms: Palmitoyl Tripeptide-1, Palmitoyl Oligopeptide, C16-GHK, C16-GK-3 

• Purity: ≥99% verified by HPLC

• pal-ghk 200mg peptide for research

Mechanism of Action in Research

Pal-GHK operates through several well-characterized mechanisms that make it a valuable research tool :

Signal Peptide Activity and Matrikine Signaling

Pal-GHK is a “signal peptide” that tells skin cells how to behave, specifically regarding reducing signs of sun damage like wrinkles and rough texture . It functions through the matrikine signaling pathway—the same endogenous GHK signaling that naturally occurs during collagen matrix remodeling . This signaling activity stimulates fibroblast production of Collagen I, Collagen III, and Fibronectin .

Collagen Synthesis and ECM Modulation

In vitro studies demonstrate that Pal-GHK (0.5 µM) increases collagen synthesis in human skin fibroblasts . When combined with Palmitoyl Tetrapeptide-7 (as Matrixyl 3000), the complex demonstrates a 258% increase in Collagen I synthesis—approximately double the collagen stimulation achieved by Pal-GHK alone under the same experimental conditions .

Dual-Action Protection

Pal-GHK not only stimulates new collagen production but also protects existing collagen from degradation. At 6 ppm concentration, it reduces collagen degradation in patient-derived human skin samples irradiated with UVA light, demonstrating a functional protective effect against matrix metalloproteinase (MMP)-mediated ECM breakdown—a hallmark of photoaging .

Enhanced Skin Permeability via Palmitoylation

Franz diffusion cell assays with 3D human reconstructed skin demonstrate that skin permeability is slightly increased by attaching a palmitoyl group at the N-terminus of GHK . This establishes the functional advantage of the palmitoyl modification for delivery applications, distinguishing Pal-GHK from unmodified GHK .

Clinical Anti-Wrinkle Efficacy

In a blinded, randomized clinical study, 28 volunteers applied a cream containing palmitoyl tripeptide-1 to one half of the face and a placebo cream to the other half twice daily, confirming quantifiable anti-wrinkle effects including reductions in wrinkle depth, volume, and density .

• pal-ghk 200mg peptide for research

Scientific Research Applications

Pal-GHK has been studied across multiple research domains :

Extracellular Matrix Modulation Research

Pal-GHK is used to investigate ECM regulation, particularly regarding collagen and matrix remodeling. Research indicates that it may stimulate the production of collagen and elastin, two proteins essential within the ECM of skin cells .

Fibroblast and Matrikine Signaling Studies

Pal-GHK is studied for its ability to stimulate fibroblast activation through matrikine signaling pathways . Researchers use Pal-GHK to study these signaling pathways and their role in tissue repair and remodeling.

Formulation Science and Delivery Research

Pal-GHK has been studied in various delivery systems including vesicular lipid systems, ethosomes, and organogels . Studies have evaluated its release kinetics from semi-solid formulations via Franz cells, demonstrating controlled release properties .

Comparative and Synergy Studies

Research has established that Pal-GHK is compatible with other cosmetic ingredients (e.g., hyaluronic acid, vitamin C) and shows no acute cytotoxicity at concentrations up to 10 µM . The peptide has also been studied in combination with Palmitoyl Tetrapeptide-7 (Matrixyl 3000 complex) .

Analytical Method Development

Pal-GHK has been used as an internal standard for the quantification of pal-KTTKS in anti-wrinkle creams by LC-MS/MS, demonstrating its utility in analytical chemistry research .

Important Research Considerations

Purity and Quality Standards
Pal-GHK is produced via solid-phase peptide synthesis (SPPS) with typical purity exceeding 95% . For research applications, higher purity (≥99%) is recommended for more precise results.

• pal-ghk 200mg peptide for research

Safety Profile
The Cosmetic Ingredient Review Expert Panel evaluated personal care products using palmitoyl tripeptide-1 between 0.0000001% to 0.001% and deemed it safe in current practice of use and concentration . No acute cytotoxicity was observed at concentrations up to 10 μM, with cell viability of human dermal fibroblasts and keratinocytes >95% .

Storage and Handling
Pal-GHK should be stored as lyophilized powder at -20°C in a sealed, desiccated container, protected from light and moisture . The peptide is soluble in DMF (30 mg/mL), DMSO (10 mg/mL), and ethanol (30 mg/mL) .

Why Choose Liaocheng Yixin Company?

When sourcing pal-ghk 200mg peptide for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC and mass spectrometry. Our Pal-GHK meets ≥99% purity standards . Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• CAS Number: 147732-56-7 

• Molecular Weight: 578.79 g/mol 

• Appearance: White to off-white lyophilized powder 

• Solubility: DMF: 30 mg/mL, DMSO: 10 mg/mL, Ethanol: 30 mg/mL 

• Storage: Store powder at -20°C in a sealed, desiccated container, protected from light and moisture 

• Form: Lyophilized powder for research use

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis (SPPS) 

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. Packaged under sterile condit

6.  pal-ghk 200mg peptide for researchions for research use

: What is Pal-GHK and how does it work in research?

A: Pal-GHK is a palmitoyl-modified tripeptide (Gly-His-Lys) that functions as a signal peptide through matrikine signaling . It stimulates fibroblast production of Collagen I, III, and Fibronectin . The palmitoyl modification enhances lipophilicity and skin penetration .

: What are the key research applications for Pal-GHK?

A: Pal-GHK is used in extracellular matrix modulation research (collagen and elastin production), fibroblast and matrikine signaling studies, formulation science and delivery research, comparative and synergy studies, and analytical method development .

: What is Matrixyl 3000 and how does Pal-GHK relate to it?

A: Matrixyl 3000 is a commercially proven anti-aging peptide complex combining Pal-GHK (Palmitoyl Tripeptide-1) with Palmitoyl Tetrapeptide-7 . The combination demonstrates a 258% increase in Collagen I synthesis—approximately double the collagen stimulation achieved by Pal-GHK alone .

: What is the evidence for Pal-GHK efficacy?

A: In vitro studies show Pal-GHK (0.5 µM) increases collagen synthesis in human skin fibroblasts . Clinical studies demonstrate quantifiable anti-wrinkle effects including reductions in wrinkle depth, volume, and density . It also protects existing collagen from degradation under UVA stress .

: What purity level can I expect?

A: All batches are tested to ensure ≥99% purity by HPLC analysis. Certificates of Analysis are available upon request.

: Is this product for human use?

A: No. Our Pal-GHK is manufactured strictly for research use only (RUO). It is not intended for human consumption or clinical applications .

When you need premium pal-ghk 200mg peptide for research for your extracellular matrix, fibroblast, or matrikine signaling studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.  pal-ghk 200mg peptide for research