CJC-1295 NO DAC (Mod GRF 1-29) (5mg) – Premium Research Peptide

Welcome to Liaocheng Yixin Company, your trusted source for premium cjc-1295 no dac mod grf 1-29 5mg for research. As a specialized peptide synthesis manufacturer operating from our facility in Shandong Province, China, we provide high-quality research compounds for the global scientific community.

CJC-1295 without DAC (also known as Modified GRF 1-29 or Mod GRF 1-29) is a synthetic analog of Growth Hormone Releasing Hormone (GHRH) featuring four specific amino acid substitutions that enhance its stability and biological activity. Unlike its DAC-conjugated counterpart, this No DAC version lacks the Drug Affinity Complex moiety, resulting in a shorter half-life that more closely mimics the body’s natural pulsatile release of growth hormone. Our cjc-1295 no dac mod grf 1-29 5mg for research offers investigators a reliable, high-purity compound for endocrinology and growth hormone axis studies.cjc-1295 no dac mod grf 1-29 5mg for research

What is CJC-1295 No DAC?

CJC-1295 without DAC, scientifically classified as Modified GRF 1-29, is a tetrasubstituted analog of the first 29 amino acids of GHRH. The modifications—substitutions at positions 2 (D-Ala), 8, 15 (Ala), and 27—confer resistance to enzymatic degradation by dipeptidyl peptidase-4 (DPP-IV) and other proteases, extending its half-life compared to native GRF 1-29 (Sermorelin).

Key identifiers:

• CAS Number: 446036-97-1

• Molecular Formula: C152H252N44O42

• Molecular Weight: 3367.9 g/mol

• Synonyms: Modified GRF 1-29, CJC-1295-no DAC, GHRH (1-29)-NH2, Tetrasubstituted GRF 1-29

• Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2

• Purity: ≥99% verified by HPLC

• cjc-1295 no dac mod grf 1-29 5mg for research

Mechanism of Action in Research

GHRH Receptor Binding and Signaling

Mod GRF 1-29 binds to the GHRH receptor (GHRHR) on anterior pituitary somatotrophs, activating Gs-coupled adenylyl cyclase signaling. This elevates intracellular cAMP, activates protein kinase A (PKA), and drives GH gene transcription and secretion.

Enhanced Stability and Half-Life

The tetrasubstitution of Mod GRF 1-29 significantly improves its resistance to enzymatic degradation. Native GRF 1-29 (Sermorelin) has a half-life of approximately 5 minutes, while Mod GRF 1-29 achieves a half-life of about 30 minutes. This extended duration makes it a more reliable research tool without the risks associated with ultra-long-acting DAC variants.

Pulsatile GH Release Preservation

Unlike the DAC-conjugated version that provides sustained, non-physiologic GH elevation (“GH bleed”), CJC-1295 No DAC supports a pulsatile release pattern that mimics the body’s natural circadian rhythm. This pulsatility is critical for maintaining normal physiologic responses and avoiding pituitary desensitization.

Scientific Research Applications

Pulsatile Signaling Research

CJC-1295 No DAC is the gold-standard reagent for investigating physiologic, pulsatile GH secretion. Researchers utilize this peptide to study how short-acting GHRH analogs amplify the natural peaks of GH secretion when timed with endogenous somatostatin inhibition.

Synergy Studies with GHRPs

Mod GRF 1-29 is frequently used in combination with GHRPs (such as Ipamorelin or GHRP-6) to study the synergistic “multiplier effect” on pituitary somatotrophs. The blend allows researchers to investigate the interconnected pathways of GH regulation.cjc-1295 no dac mod grf 1-29 5mg for research

Sleep Architecture and Chronobiology

Research investigates the impact of amplified GH pulses on Slow Wave Sleep (SWS) and recovery cycles in animal models. This application explores the relationship between growth hormone dynamics and circadian rhythms.

Metabolic and Body Composition Studies

Investigations explore the effects of Mod GRF 1-29 on adipose tissue function, including lipolysis, adipogenesis, and adipokine secretion. Researchers also study its impact on osteoblast activity, bone mineral density, and collagen synthesis.

Endocrinology and Cellular Signaling

Mod GRF 1-29 provides insights into endocrine feedback mechanisms and intracellular signaling networks by engaging growth hormone-related pathways. This research advances the understanding of hormonal regulation in both normal and disease states.

Why Choose Liaocheng Yixin Company?

When sourcing cjc-1295 no dac mod grf 1-29 5mg for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. Independent analysis confirms peptide purity exceeding 99%. Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• Appearance: Lyophilized powder

• Solubility: DMSO: 1 mg/mL, DMF: slightly soluble

• Storage: Store at -20°C; -80°C for up to 6 months

• Form: Lyophilized powder for research use

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase techniques

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. TFA Removal via acetate exchange for cell culture applications

6. cjc-1295 no dac mod grf 1-29 5mg for research

: What is the difference between CJC-1295 No DAC and CJC-1295 with DAC?

A: CJC-1295 with DAC contains a Drug Affinity Complex that binds to serum albumin, extending its half-life to approximately 8 days and providing sustained GH elevation. CJC-1295 No DAC lacks this complex, has a half-life of about 30 minutes, and supports pulsatile GH release that mimics natural circadian rhythms.

: How does Mod GRF 1-29 compare to Sermorelin (GRF 1-29)?

A: Mod GRF 1-29 features four amino acid substitutions that protect it from enzymatic degradation, extending its half-life from ~5 minutes (Sermorelin) to ~30 minutes. This makes it a more stable and reliable research tool.

: What research applications use CJC-1295 No DAC?

A: The peptide is used in pulsatile signaling research, synergy studies with GHRPs, sleep architecture research, metabolic and body composition studies, and endocrinology investigations.

: What purity level can I expect?

A: All batches are tested to ensure ≥99% purity by HPLC analysis. Certificates of Analysis are available upon request.

: Is this product for human use?

A: No. Our CJC-1295 No DAC is manufactured strictly for research use only (RUO). It is not intended for human consumption or clinical applications.

When you need premium cjc-1295 no dac mod grf 1-29 5mg for research for your growth hormone axis, metabolic, or chronobiology studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.