FOXO4-DRI (10mg) – Premium Senolytic Peptide for Cellular Aging Research

Welcome to Liaocheng Yixin Company, your trusted source for premium foxo4-dri 10mg peptide for research. As a specialized peptide synthesis manufacturer operating from our facility at No. 9 Lushan Road, Dongcheng Street, Liaocheng Economic and Technological Development Zone, Shandong Province, we provide high-quality research compounds for the global scientific community. foxo4-dri 10mg peptide for research

FOXO4-DRI is a cell-permeable peptide antagonist that selectively targets and induces apoptosis in senescent cells by disrupting the interaction between the transcription factor FOXO4 and the tumor suppressor protein p53 . This innovative senolytic peptide has been shown to restore tissue homeostasis, reverse age-related decline, and neutralize chemotherapy-induced toxicity in preclinical models . Our foxo4-dri 10mg peptide for research offers investigators a reliable, high-purity compound for senescence, aging, and regenerative medicine studies.

What is FOXO4-DRI?

FOXO4-DRI (Forkhead Box O4-D-Retro-Inverso) is a synthetic peptide specifically designed to bind to p53 with greater stability than the natural FOXO4 protein, competitively inhibiting the FOXO4-p53 interaction that helps maintain senescent cells . The peptide is a cell-permeable antagonist that induces apoptosis of senescent cells while sparing non-senescent populations .

Key identifiers:

• CAS Number: 2460055-10-9 

• Molecular Formula: C₂₂₈H₃₈₈N₈₆O₆₄ 

• Molecular Weight: 5358.06 g/mol 

• Sequence: D-(Leu-Thr-Leu-Arg-Lys-Glu-Pro-Ala-Ser-Glu-Ile-Ala-Gln-Ser-Ile-Leu-Glu-Ala-Tyr-Ser-Gln-Asn-Gly-Trp-Ala-Asn-Arg-Arg-Ser-Gly-Gly-Lys-Arg-Pro-Pro-Pro-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly) 

• Synonyms: FOXO4-D-Retro-Inverso peptide

• Purity: ≥99% verified by HPLC 

• foxo4-dri 10mg peptide for research

Mechanism of Action in Research

FOXO4-DRI exerts its senolytic effects through a highly specific and selective mechanism :

Targeted Disruption of FOXO4-p53 Interaction

FOXO4-DRI is a peptide antagonist that blocks the interaction between FOXO4 and p53, a well-established inducer of senescence . The competitive inhibition of this complex forces the disruption of a survival pathway that is crucial for senescent cells .

Nuclear Exclusion and Apoptosis Induction

By inhibiting FOXO4-p53 binding, the peptide facilitates the nuclear exclusion of phosphorylated p53, which then translocates to the mitochondria to initiate apoptosis . This mechanism activates the p53/BCL-2/Caspase-3 signaling pathway, triggering BAX and cleaved caspase-3 to promote apoptosis . The resulting process is non-inflammatory, as apoptosis does not create further inflammation, unlike necrotic cell death .

High Selectivity for Senescent Cells

FOXO4-DRI’s mechanism is highly selective because senescent cells are dependent on the FOXO4-p53 interaction for their survival . The peptide has been shown to efficiently kill senescent cells without affecting non-senescent cells when administered in a range of concentrations . This selectivity is a key advantage over other senolytic agents that target more general survival pathways .

Scientific Research Applications

FOXO4-DRI has been studied across multiple research domains:

Aging and Longevity Research

FOXO4-DRI is the anchor of the senolytic category and is a primary research tool for investigating cellular senescence. Research has demonstrated that FOXO4-DRI reduces markers of senescence and improves physiological function in aged mice :

• Restoration of Kidney Function: Reversed age-related decline in kidney biomarkers .

• Physical Function Improvement: Restored fur density and increased voluntary physical activity .

• Reversal of Testicular Aging: Increased serum testosterone levels and reduced senescence markers in naturally aged mice .

Pulmonary Fibrosis Research

FOXO4-DRI has been investigated in models of fibrosis. A 2022 study published in Nature Communications found that FOXO4-DRI decreased senescent cells, downregulated the senescence-associated secretory phenotype (SASP), and attenuated bleomycin-induced morphological changes and collagen deposition . The peptide was shown to decrease myofibroblasts and reduce the extracellular matrix (ECM) receptor interaction pathway .

Cardiovascular and Endothelial Research

A 2025 study in Frontiers in Bioengineering and Biotechnology demonstrated that FOXO4-DRI regulates endothelial cell senescence via the p53 signaling pathway . The research found that FOXO4-DRI alleviates endothelial cell senescence, enhances endothelial cell function, and suppresses aortic aging . It also downregulates pro-inflammatory cytokines IL-1β, IL-6, IL-8, and TNF-α .

Chemotherapy-Induced Senescence Models

FOXO4-DRI has been studied in models of chemotherapy-induced senescence. In doxorubicin-treated mice, FOXO4-DRI cleared senescent cells and neutralized the drug’s toxic side effects . This suggests potential research applications for evaluating senolytic agents in mitigating therapy-related side effects.

Why Choose Liaocheng Yixin Company?

When sourcing foxo4-dri 10mg peptide for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. Certificates of Analysis confirming purity exceeding 99% are available upon request .

Research-Grade Specifications

• foxo4-dri 10mg peptide for research

• Purity: ≥99% verified by HPLC

• Appearance: White to off-white lyophilized powder 

• Solubility: Soluble in H₂O (125.75 mg/mL), DMSO (50 mg/mL) 

• Storage: Store powder at -20°C in a sealed, desiccated container, protected from light and moisture 

• Form: Lyophilized powder for research use

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis

2. Purification via preparative HPLC

3. foxo4-dri 10mg peptide for research

4. Analysis using HPLC for purity verification (>99%)

5. Mass Spectrometry for molecular weight confirmation

6. Packaged in sterile conditions for research use

: What is FOXO4-DRI and how does it work in research?

A: FOXO4-DRI is a cell-permeable peptide antagonist that blocks the interaction between FOXO4 and p53 . This disruption forces the nuclear exclusion of phosphorylated p53, which then translocates to the mitochondria to initiate apoptosis in senescent cells . The peptide has been shown to selectively kill senescent cells without affecting non-senescent populations .

: What is the significance of FOXO4-DRI’s selectivity?

A: FOXO4-DRI’s specificity is a major point of interest in senescence research. The FOXO4-p53 interaction is a key survival pathway primarily in senescent cells, so FOXO4-DRI should, in principle, have little to no effect on healthy, proliferating cells . This is a significant advantage over other senolytic agents that target more general survival pathways .

: What research applications use FOXO4-DRI?

A: FOXO4-DRI is used in aging and longevity research, pulmonary fibrosis studies, endothelial function research, chemotherapy-induced senescence models, and various other investigations involving cellular senescence .

: Is there published human research on FOXO4-DRI?

A: As of current literature, there are no published, peer-reviewed human clinical trials for FOXO4-DRI . The effects in humans—including efficacy, dosage, safety, and side effects—remain unknown. The peptide is for research use only.

: What purity level can I expect?

A: All batches are tested to ensure ≥99% purity by HPLC analysis. Certificates of Analysis are available upon request.

: Is this product for human use?

A: No. Our FOXO4-DRI is manufactured strictly for research use only (RUO). It is not intended for human consumption or clinical applications.

When you need premium foxo4-dri 10mg peptide for research for your senescence, aging, or regenerative medicine studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.foxo4-dri 10mg peptide for research