GHK-Cu (Copper) (50mg) – Premium Research Peptide for Regenerative Studies

Welcome to Liaocheng Yixin Company, your trusted source for premium ghk-cu 50mg for research. As a specialized peptide synthesis manufacturer operating from our facility in Shandong Province, China, we provide high-quality research compounds for the global scientific community.

GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring tripeptide found in human plasma, saliva, and urine that declines significantly with age . First identified in human plasma in the 1970s, this copper-peptide complex has been extensively studied for its regenerative, anti-inflammatory, and neuroprotective properties . Our ghk-cu 50mg for research offers investigators a reliable, high-purity compound for tissue regeneration, extracellular matrix research, and cognitive aging studies.

What is GHK-Cu?

GHK-Cu (CAS: 49557-75-7) is a copper-complexed tripeptide with the amino acid sequence Gly-His-Lys (GHK) that binds copper ions with high affinity through the histidine imidazole ring . The copper component is essential for biological activity—the peptide’s mechanism involves facilitating copper uptake into cells . Reconstituted solutions typically appear slightly blue, a characteristic colour indicating proper copper binding .

Key Identifiers:

• CAS Number: 49557-75-7

• Molecular Formula: C₁₄H₂₃N₆O₄Cu (GHK‑Cu complex)

• Molecular Weight: ~401.91 g/mol 

• Sequence: Gly-His-Lys(Cu²⁺)

• Synonyms: Copper peptide, Copper Tripeptide-1, GHK-Cu acetate

• Purity: ≥99% verified by HPLC

Mechanism of Action in Research

GHK-Cu exerts its effects through multiple mechanisms that make it valuable across research domains:

Gene Expression Modulation

GHK-Cu can influence the expression of over 4,000 genes, including those involved in antioxidant responses, DNA repair, and extracellular matrix remodelling . At the molecular level, copper binding increases the metal’s availability to lysyl oxidase and superoxide dismutase (SOD), enzymes critical for connective tissue integrity and oxidative stress defense .

Extracellular Matrix & Collagen Regulation

GHK-Cu stimulates collagen and glycosaminoglycan synthesis in skin fibroblasts, directly supporting tissue structural integrity . Studies have demonstrated that the combination of GHK-Cu and hyaluronic acid synergistically enhances collagen synthesis in fibroblasts and skin models . Research has also documented effects on collagen production, fibroblast function, and angiogenesis .

Anti-Inflammatory & Antioxidant Effects

GHK-Cu suppresses pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6, while promoting anti-inflammatory cytokine expression . In zebrafish inflammation models, GHK-Cu significantly decreased neutrophil and macrophage migration, suppressed pro-inflammatory cytokine expression, and improved SOD activity . Pathway analysis revealed downregulation of the JAK1-STAT3 pathway . In an injectable gel composite study, GHK-Cu reduced inflammatory factors including NO, TNF-α, IL-1β, and IL-6 .

Cognitive Aging & Neuroprotection

Recent research in aged mice (20-21 months) demonstrated that GHK-Cu improves hippocampal-dependent learning through distinct biological modes depending on administration route . Intranasal GHK-Cu treatment (8 weeks) improved cognitive performance in both sexes, inducing coordinated suppression of oxidative phosphorylation and MYC target pathways. The study identified that GHK-Cu can improve cognitive function through divergent molecular programs—short-term exposure activates repair pathways, while sustained delivery promotes metabolic and transcriptional remodeling of aging neural circuits .

Scientific Research Applications

GHK-Cu is a well-established research tool across multiple domains:

Dermal & Connective Tissue Research

• Fibroblast function and collagen synthesis studies

• Extracellular matrix organization and tissue structure markers

• Copper-linked changes in collagen-associated pathways

Wound Healing & Tissue Regeneration

• Connective tissue deposition and angiogenesis studies

• Preclinical models of wound repair and tissue response

• Scarless wound healing mechanisms 

Inflammation & Oxidative Stress Research

• Investigation of antioxidant pathways

• Cytokine profiling and inflammatory signaling

• JAK1-STAT3 pathway modulation 

Cognitive & Neuroprotection Studies

• Hippocampal-dependent learning mechanisms

• Aging-related transcriptional changes

• Glial activation and synapse studies

Why Choose Liaocheng Yixin Company?

When sourcing ghk-cu 50mg for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. Our GHK-Cu meets ≥99% purity standards with identity and mass confirmed by analytical methods such as HPLC and MS, with lot-specific data documented on the Certificate of Analysis .

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• Appearance: Lyophilised powder (blue/purple tint characteristic of copper binding)

• Storage: Store powder at -20°C or below, protected from light and moisture; avoid repeated freeze-thaw cycles 

• Form: Lyophilised powder for research use

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. Copper content verification to confirm proper complex formation

When you need premium ghk-cu 50mg for research for your tissue regeneration, inflammatory, or cognitive aging studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.