GHRP-2 (5mg) – Premium Research Peptide for Endocrine and Receptor Studies

Welcome to Liaocheng Yixin Company, your trusted source for premium ghrp-2 5mg peptide for research. As a specialized peptide synthesis manufacturer operating from our facility at No. 9 Lushan Road, Dongcheng Street, Liaocheng Economic and Technological Development Zone, Shandong Province, we provide high-quality research compounds for the global scientific community.ghrp-2 5mg peptide for research

GHRP-2 (Pralmorelin) is a synthetic hexapeptide belonging to the growth hormone secretagogue family. It is widely studied for its potent interaction with the ghrelin receptor (GHS-R1a), making it a valuable tool for investigating endocrine signaling, receptor pharmacology, and neuroendocrine communication . Our ghrp-2 5mg peptide for research offers investigators a reliable, high-purity compound for growth hormone axis and immunomodulation studies.

What is GHRP-2?

GHRP-2 (Growth Hormone-Releasing Peptide-2), also known as Pralmorelin, is a synthetic hexapeptide with the sequence DAla-2-DNal-Ala-Trp-DPhe-Lys-NH2 . It acts as a potent agonist of the growth hormone secretagogue receptor type 1a (GHS-R1a), the endogenous receptor for ghrelin . Its molecular weight is approximately 817.9 Da .

Key identifiers:

• CAS Number: 158861-67-7 

• Molecular Weight: 817.9 Da

• Sequence: DAla-2-DNal-Ala-Trp-DPhe-Lys-NH2 

• Synonyms: Pralmorelin, GHRP-2

• Purity: ≥99% verified by HPLC

• ghrp-2 5mg peptide for research

Mechanism of Action in Research

GHRP-2 exerts its effects through specific receptor-mediated pathways that are well-characterized in the scientific literature:

GHS-R1a Receptor Activation

GHRP-2 binds to the ghrelin receptor (GHS-R1a) expressed in the hypothalamus and pituitary gland . This activation triggers a signaling cascade involving Gq-coupled phospholipase C (PLC), generating IP3 and DAG, mobilizing intracellular calcium, and ultimately stimulating growth hormone (GH) secretion .

Distinct from GHRH Receptor

GHRP-2 acts through a receptor distinct from the GHRH receptor (GHRHR), meaning its mechanism is complementary to, rather than redundant with, GHRH signaling . Research demonstrates that GHRP-2 does not act via the GRF receptor, confirming its unique pharmacological profile .

Synergistic Action with GHRH

In experimental systems, GHRP-2 acts synergistically with GHRH to release GH, co-administration producing greater responses than either peptide alone . The GHRPs share a common receptor and mechanism, as GHRP-2 and GHRP-6 stimulate GH release via the same receptor and can desensitize cells to each other, but not to GHRH .

Scientific Research Applications

Growth Hormone Secretagogue Research

GHRP-2 is utilized in laboratory models investigating growth hormone signaling, endocrine regulation, and receptor-mediated cellular communication . Its ability to markedly increase plasma GH levels makes it a valuable tool for studying hypothalamic-pituitary function .

Receptor Pharmacology Studies

Researchers study GHRP-2 for its interaction with GHS-R1a and related receptors. Data indicates potential activity at RXFP3 and RXFP4 receptors, providing avenues for broader receptor pharmacology investigation .ghrp-2 5mg peptide for research

Anti-Inflammatory Research

GHRP-2 has demonstrated anti-inflammatory properties in experimental models. In arthritic rat models, GHRP-2 administration decreased arthritis scores, reduced paw volume, and lowered circulating IL-6 levels, with effects mediated through ghrelin receptors directly on immune cells . In endotoxemia models, GHRP-2 attenuated liver damage, decreased transaminases, and reduced TNF-alpha expression .

Neuroendocrine Communication

GHRP-2 is studied in investigations involving hypothalamic and pituitary signaling mechanisms, providing insights into neuroendocrine communication and hormonal regulation .

Why Choose Liaocheng Yixin Company?

When sourcing ghrp-2 5mg peptide for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. Certificates of Analysis confirming purity exceeding 99% are available upon request .

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• Appearance: White lyophilized powder 

• Storage: Store powder at -20°C in a sealed container, protected from light and moisture 

• Form: Lyophilized powder for research use

• ghrp-2 5mg peptide for research

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. Packaged in sterile conditions for research use 

6. ghrp-2 5mg peptide for research

: How does GHRP-2 work in research models?

A: GHRP-2 is a potent agonist of the ghrelin receptor (GHS-R1a). Its primary research use is to stimulate growth hormone release via a receptor distinct from GHRH . It is studied in experiments focused on hormone regulation, endocrine signaling, and receptor pharmacology .

: How does GHRP-2 compare with Ipamorelin?

A: In research models, GHRP-2 produces more GH per dose than Ipamorelin but has lower receptor selectivity—it is associated with increased cortisol and prolactin alongside GH, whereas Ipamorelin is more selective for somatotrophic GHS-R1a . GHRP-2 is useful for research requiring the broader pharmacology of the ghrelin receptor system.

: What research applications use GHRP-2?

A: GHRP-2 is used in growth hormone secretagogue research, receptor activation studies, neuroendocrine research, hormonal regulation studies, and anti-inflammatory research .

: What purity level can I expect?

A: All batches are tested to ensure ≥99% purity by HPLC analysis. Certificates of Analysis are available upon request .

: Is this product for human use?

A: No. Our GHRP-2 is manufactured strictly for research use only (RUO). It is not intended for human consumption or clinical applications .

When you need premium ghrp-2 5mg peptide for research for your endocrine, receptor pharmacology, or immunomodulation studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.