Gonadorelin (GnRH) (10mg) – Premium Research Decapeptide

Welcome to Liaocheng Yixin Company, your trusted source for premium gonadorelin gnrh 10mg for research. As a specialized peptide synthesis manufacturer operating from our facility at No. 9 Lushan Road, Dongcheng Street, Liaocheng Economic and Technological Development Zone, Shandong Province, we provide high-quality research compounds for the global scientific community.

Gonadorelin is a synthetic decapeptide identical to the naturally occurring gonadotropin-releasing hormone (GnRH) produced by the hypothalamus . As a cornerstone of reproductive research, it plays a pivotal role in regulating the hypothalamic-pituitary-gonadal (HPG) axis . Our gonadorelin gnrh 10mg for research offers investigators a reliable, high-purity compound for endocrinology, reproductive physiology, and neuroendocrine studies.

What is Gonadorelin?

Gonadorelin is a synthetic decapeptide (10-amino-acid chain) prepared using solid-phase peptide synthesis . It serves as a specific agonist for the GnRH receptor , triggering a signaling cascade that promotes the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland .

Key identifiers:

• CAS Number: 34973-08-5 

• Molecular Formula: C57H79N17O15 

• Molecular Weight: 1242.34 g/mol 

• Synonyms: GnRH, Gonadorelin acetate, LHRH, LH-RH

• Purity: ≥99% verified by HPLC

• gonadorelin gnrh 10mg for research

Mechanism of Action in Research

Gonadorelin exerts its effects through specific receptor-mediated signaling:

GnRH Receptor Activation

Gonadorelin binds to GnRH receptors in the anterior pituitary gland . Upon binding, it activates the phosphatidylinositol pathway, which leads to the activation of protein kinase C and calmodulin through increased calcium ion levels in the cytoplasm . This signaling cascade drives the synthesis and secretion of both LH and FSH .

Pulse Frequency-Dependent Effects

The frequency and amplitude of GnRH pulses determine the ratio of LH and FSH secreted . This differential regulation is a cornerstone of reproductive physiology—high-frequency administration favors LH secretion, while low-frequency administration promotes FSH secretion . This makes gonadorelin a powerful tool for investigating how hormone pulse patterns influence reproductive function. gonadorelin gnrh 10mg for research

Short Half-Life

Gonadorelin has a short half-life in the systemic circulation of approximately 2-4 minutes following intravenous administration . After intramuscular administration in cows, the plasma half-life is approximately 20 minutes . This rapid clearance requires infusion pumps for continuous pulsatile administration in certain applications .

Scientific Research Applications

Endocrine Signaling Studies

Gonadorelin is studied in laboratory models investigating hypothalamic-pituitary-gonadal axis function, reproductive endocrinology, and receptor-mediated hormonal regulation .

Receptor Pharmacology

As a specific GnRH receptor agonist, gonadorelin is used to investigate receptor binding affinity, signal transduction pathways, and receptor regulation . Research demonstrates that gonadorelin binds with high specificity to GnRH receptors .

Reproductive Research

Gonadorelin is widely used in models of ovulation induction, fertility, and spermatogenesis . In women with hypothalamic amenorrhea, pulsatile administration mimics physiological GnRH secretion to induce ovulation . In male research models, gonadorelin has been studied for its ability to stimulate testicular function and spermatogenesis .

Immunological and Cancer Research

In vitro studies have examined gonadorelin’s effects on cancer cell proliferation . Research suggests GnRH agonists may exhibit potential in mitigating mitogen action in healthy cells . Studies have also investigated gonadorelin in the context of breast and prostate cancer research models .

Why Choose Liaocheng Yixin Company?

When sourcing gonadorelin gnrh 10mg for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. Commercially available gonadorelin typically achieves HPLC purity ≥98.0% and peptide content ≥80.0% by weight . Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• Appearance: White lyophilized powder

• Solubility: DMSO ≥12.5 mg/mL; 25mg/mL in water 

• Storage: Store powder at -20°C in a sealed container, protected from light and moisture 

• Form: Lyophilized powder for research use 

• gonadorelin gnrh 10mg for research

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis 

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. Packaged in sterile conditions for research use

: What is gonadorelin and how does it work in research?

A: Gonadorelin is a synthetic decapeptide identical to natural GnRH . It activates GnRH receptors in the anterior pituitary, stimulating synthesis and secretion of LH and FSH . Its effects depend on pulse frequency—high-frequency pulses favor LH, while low-frequency pulses favor FSH .

: What is the half-life of gonadorelin?

A: Gonadorelin has a short half-life of approximately 2-4 minutes following intravenous administration . Following intramuscular injection, the plasma half-life is approximately 20 minutes . This rapid clearance necessitates pulsatile delivery to mimic physiological conditions .

: What research applications use gonadorelin?

A: Gonadorelin is used in endocrine signaling studies, receptor pharmacology, reproductive research (ovulation induction, spermatogenesis models), and immunological/cancer research .

: What purity level can I expect?

A: All batches are tested to ensure ≥99% purity by HPLC analysis. Certificates of Analysis are available upon request. USP-grade specifications typically require ≥80% peptide content by weight .

: How should gonadorelin be stored?

A: Store lyophilized powder at -20°C in a sealed container, protected from light and moisture. Stock solutions should be stored at -80°C for up to 6 months or -20°C for up to 1 month .

: Is this product for human use?

A: No. Our gonadorelin is manufactured strictly for research use only (RUO). It is not intended for human consumption or clinical applications .

When you need premium gonadorelin gnrh 10mg for research for your endocrinology, reproductive physiology, or receptor signaling studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.