Hexarelin (5mg) – Premium Research Peptide

Welcome to Liaocheng Yixin Company, your trusted source for premium hexarelin 5mg peptide for research. As a specialized peptide synthesis manufacturer operating from our facility at No. 9 Lushan Road, Dongcheng Street, Liaocheng Economic and Technological Development Zone, Shandong Province, we provide high-quality research compounds for the global scientific community.

Hexarelin is a synthetic hexapeptide growth hormone secretagogue (GHS) known for its potent stimulation of the growth hormone secretagogue receptor (GHSR), also known as the ghrelin receptor . It was developed as an analog of GHRP-6 with enhanced stability and efficacy . Our hexarelin 5mg peptide for research offers investigators a reliable, high-purity compound for a wide range of research applications, from endocrine signaling to cardiovascular protection.

What is Hexarelin?

Hexarelin (Examorelin) is a synthetic growth hormone-releasing peptide with the sequence His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH2 . It is a potent, synthetic agonist of the growth hormone secretagogue receptor (GHS-R1a) .

Key Identifiers:

• CAS Number: 140703-51-1 

• Molecular Formula: C47H58N12O6 

• Molecular Weight: 887.04 g/mol 

• Synonyms: Examorelin, GHRP, Growth Hormone Releasing Hexapeptide

• Sequence: His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH2 

• Purity: ≥99% verified by HPLC

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Mechanism of Action in Research

Hexarelin’s pharmacological profile is characterized by its dual receptor interactions and complex signaling pathways .

GHS-R1a and CD36 Receptor Binding

Hexarelin acts through two primary receptors: the growth hormone secretagogue receptor 1a (GHS-R1a) and the scavenger receptor CD36 . It exhibits a significantly higher affinity for GHS-R1a (IC50 = 15.9 nM) over CD36 (IC50 = 2,080 nM) . This dual binding profile underpins its multifaceted research applications.

Growth Hormone Secretagogue Activity

Hexarelin powerfully stimulates GH secretion in a time- and dose-dependent manner . However, its mechanism of GH release is complex. Studies suggest it involves three, not mutually exclusive, processes:

1. Direct action on the pituitary (though of minor relevance) .

2. Indirect action involving the release of GHRH (particularly relevant in adult rats) .

3. Action through the release of an unknown hypothalamic factor, which acts synergistically with GHRH to stimulate GH release .

Notably, Hexarelin also stimulates the hypothalamic-pituitary-adrenal (HPA) axis . This effect is likely mediated, at least in part, through the stimulation of arginine vasopressin (AVP) rather than corticotrophin-releasing hormone (CRH) .

Cardioprotective Signaling

At the cellular level, hexarelin activates several pro-survival signaling cascades, including anti-apoptotic pathways that upregulate Bcl-2 and downregulate Bax . In cardiomyocytes, hexarelin increases the L-type Ca2+ current (ICa,L) via a GHS-R1a and protein kinase C (PKC) signaling pathway, contributing to a positive inotropic effect . This mechanism protects cells from ischemia/reperfusion injury and other forms of stress .

Scientific Research Applications

Hexarelin is a versatile tool in several research domains:

Cardiovascular and Cardioprotective Research:

• Ischemia/Reperfusion Injury: Protects cardiomyocytes from I/R injury by modifying the IL-1 signaling pathway and improving cardiac systolic function .

• Heart Failure: Improves cardiac dysfunction and cachexia in animal models .

• Cardiac Function: Induces a direct positive inotropic effect on cardiomyocytes by modulating Ca2+ homeostasis .

Endocrine Research:

• Growth Hormone Axis: A powerful tool for studying GH secretion dynamics and GHS receptor function in the hypothalamus and pituitary .

• HPA Axis: Investigates the neuroendocrine regulation of the stress response .

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Cellular and Receptor Pharmacology:

• Receptor Biology: Used to study GHS-R1a and CD36 signaling pathways and their modulation .

Why Choose Liaocheng Yixin Company?

When sourcing hexarelin 5mg peptide for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. Our Hexarelin meets ≥99% purity standards. Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• Appearance: White lyophilized powder

• Storage: Store powder at -20°C in a sealed, desiccated container, protected from light and moisture

• Form: Lyophilized powder for research use

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Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. Packaged in sterile conditions for research use

6. hexarelin 5mg peptide for research

: How does Hexarelin differ from other growth hormone secretagogues like GHRP-6?

A: Hexarelin is an analog of GHRP-6 with a (2-Me)Trp substitution, which confers enhanced stability and potency . It is more effective than GHRP-6 in stimulating GH release . However, unlike some other secretagogues, Hexarelin also stimulates cortisol, ACTH, and PRL release .

: What are the key research applications for Hexarelin?

A: Hexarelin is a valuable research tool in cardiovascular studies for its cardioprotective effects  and in endocrinology for investigating the GH and HPA axes . It is also used in receptor pharmacology and cellular signaling studies .

: Is Hexarelin suitable for long-term receptor studies?

A: Hexarelin has been shown to regulate the expression of its own receptor (GHS-R1a) at the pituitary and hypothalamic levels . Researchers should consider this when designing prolonged experiments, as receptor expression can be modulated by the peptide.

: What purity level can I expect?

A: All batches are tested to ensure ≥99% purity by HPLC analysis. Certificates of Analysis are available upon request.

: Is this product for human use?

A: No. Our Hexarelin is manufactured strictly for research use only (RUO). It is not intended for human consumption or clinical applications .

When you need premium hexarelin 5mg peptide for research for your cardiovascular, endocrine, or receptor signaling studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you canhexarelin 5mg peptide for research trust.