Nonapeptide-1 (200mg) – Premium MC1R Antagonist Peptide for Research

Welcome to Liaocheng Yixin Company, your trusted source for premium nonapeptide-1 200mg for research. As a specialized peptide synthesis manufacturer operating from our facility in Shandong Province, China, we provide high-quality research compounds for the global scientific community.

Nonapeptide-1 is a synthetic peptide hormone that functions as a selective antagonist of the melanocortin 1 receptor (MC1R), one of the key regulators of melanogenesis in human skin . By blocking the action of α-melanocyte-stimulating hormone (α-MSH), it prevents the cascade of signals that lead to melanin production . Our nonapeptide-1 200mg for research offers investigators a reliable, high-purity compound for dermatological, pigmentation, and MC1R pharmacology studies.

What is Nonapeptide-1?

Nonapeptide-1 is a synthetic 9-amino-acid peptide with the sequence H-Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH₂ (MP-DPhe-R-DTrp-FKPV-NH₂) . It was developed through the screening of a multi-use peptide library based on the α-MSH-[5-13] sequence and is designed to mimic the structure of the natural melanocortin ligand while opposing its activity .

Key identifiers:

• CAS Number: 158563-45-2 

• Molecular Formula: C₆₁H₈₇N₁₅O₉S 

• Molecular Weight: 1206.50 g/mol 

• Sequence: H-MP-DPhe-R-DTrp-FKPV-NH₂ 

• Synonyms: Melanostatine-5

• Purity: ≥99% verified by HPLC

Mechanism of Action in Research

Nonapeptide-1 exerts its effects through a highly specific receptor antagonism mechanism at the MC1R .

Competitive α-MSH Receptor Antagonism

Nonapeptide-1 acts as a competitive antagonist of the α-MSH receptor MC1R, binding to the same site as the natural melanocortin ligand . Its binding affinity for MC1R is characterized by a Ki of 40 nM, with remarkable selectivity over related melanocortin receptors MC3R, MC4R, and MC5R (Ki values of 0.47, 1.34, and 2.4 μM, respectively) . This makes Nonapeptide-1 a highly selective tool for studying MC1R-specific signaling pathways.

Inhibition of Melanogenesis Signaling

Upon binding to MC1R, Nonapeptide-1 blocks the intracellular signaling cascade that normally follows α-MSH activation. It inhibits α-MSH-induced cAMP accumulation in melanocytes with an IC₅₀ of 2.5 nM and prevents α-MSH-induced melanosome dispersion with an IC₅₀ of 11 nM . This downstream signaling blockade downregulates the expression of key melanogenic enzymes and transcription factors—including tyrosinase, TRP1, TRP2, and MITF—through MC1R binding .

Scientific Research Applications

Nonapeptide-1 has been studied across several research domains:

Dermatological and Pigmentation Research

Nonapeptide-1 has demonstrated potent melanin-inhibiting properties in human epidermal melanocytes (HEM) and HaCaT keratinocyte models . At a concentration of 20 μM, it inhibited basal melanin synthesis and reversed UVA-induced melanin increase . Its ultra-low IC₅₀ of 2.5 nM makes it one of the most potent melanogenesis inhibitors available for research use . This high potency is particularly valuable for studying the molecular pathways of skin pigmentation disorders, including melasma and UV-induced hyperpigmentation .nonapeptide-1 200mg for research

MC1R Pharmacology and Melanocortin Signaling

As a highly selective MC1R antagonist, Nonapeptide-1 serves as a valuable research tool for studying melanocortin receptor interactions and understanding the structural determinants required for receptor antagonism . It provides a cleaner, more targeted approach to melanogenesis research compared to enzymatic inhibitors, as it interferes with the hormonal trigger of pigmentation rather than enzymatic activity . Researchers use it to investigate α-MSH-receptor interactions, cAMP signaling pathways, and regulatory mechanisms of melanin production.

Skin Cancer and Steroid Regulation Research

Nonapeptide-1 has been investigated for its potential in research on the regulation of steroid production in the adrenal gland and skin cancer models . Its ability to inhibit melanin synthesis and reduce melanocyte activation makes it relevant for studies on pigment-related disorders. nonapeptide-1 200mg for research

Why Choose Liaocheng Yixin Company?

When sourcing nonapeptide-1 200mg for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards, producing Nonapeptide-1 via solid-phase peptide synthesis (SPPS) .

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC and mass spectrometry. Our Nonapeptide-1 meets ≥99% purity standards. Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• CAS Number: 158563-45-2 

• Appearance: White to off-white lyophilized powder 

• nonapeptide-1 200mg for research

• Storage: Store powder at -20°C in a sealed, desiccated container, protected from light and moisture (sealed storage, away from moisture, stable for 2 years at -80°C or 1 year at -20°C) 

• Form: Lyophilized powder for research use

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis (SPPS) 

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. Packaged in sterile conditions for research use

6. nonapeptide-1 200mg for research

: What is Nonapeptide-1 and how does it work in research?

A: Nonapeptide-1 is a synthetic peptide hormone that acts as a competitive antagonist of the MC1R (melanocortin 1 receptor), blocking α-MSH-induced melanogenesis . It inhibits intracellular cAMP accumulation and melanosome dispersion, downregulating key melanogenic enzymes including tyrosinase, TRP1, TRP2, and MITF .

: What is the binding affinity of Nonapeptide-1 for MC1R?

A: Nonapeptide-1 has an IC₅₀ of 2.5 nM for inhibiting α-MSH-induced cAMP and 11 nM for inhibiting melanosome dispersion . It exhibits a Ki of 40 nM for MC1R with high selectivity over MC3R, MC4R, and MC5R .

: What research applications use Nonapeptide-1?

A: Nonapeptide-1 is used in dermatological and pigmentation research (melanin inhibition, melasma, UV-induced hyperpigmentation), MC1R pharmacology studies, melanocortin signaling research, and skin cancer investigations .

: How does Nonapeptide-1 compare to other melanin inhibitors?

A: Nonapeptide-1’s ultra-low IC₅₀ (2.5 nM) makes it one of the most potent melanogenesis inhibitors available for research. Its receptor-level specificity means it interferes with the hormonal trigger of pigmentation rather than enzymatic activity, providing clean, targeted inhibition without melanocyte toxicity .

: What purity level can I expect?

A: All batches are tested to ensure ≥99% purity by HPLC analysis. Certificates of Analysis are available upon request.

: Is this product for human use?

A: No. Our Nonapeptide-1 is manufactured strictly for research use only (RUO). It is not intended for human consumption or clinical applications.

When you need premium nonapeptide-1 200mg for research for your dermatological, pigmentation, or MC1R pharmacology studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.