P21 (5mg) – Premium Research Peptide for Neurogenesis & Alzheimer’s Studies

Welcome to Liaocheng Yixin Company, your trusted source for premium p21 5mg for research. As a specialized peptide synthesis manufacturer operating from our facility in Shandong Province, China, we provide high-quality research compounds for the global scientific community.

P21 (also designated P021) is a synthetic neurotrophic peptide derived from ciliary neurotrophic factor (CNTF) that is designed to promote neurogenesis, enhance cognitive function, and cross the blood-brain barrier . It was developed to capture the neuro-regenerative properties of CNTF while avoiding its undesirable side effects, making it one of the most promising neurogenic peptides in Alzheimer’s disease and cognitive research . Our p21 5mg for research offers investigators a reliable, high-purity compound for neuroscience, neurodegenerative disease, and cognitive enhancement studies.

What is P21?

P21 is a 21-amino-acid fragment derived from the C-terminal portion of ciliary neurotrophic factor (CNTF), identified through structure-activity relationship studies that isolated its neurotrophic activity . The peptide is engineered with an adamantane-based amino acid residue that enhances lipophilicity and facilitates transport across the blood-brain barrier . It is also known as Peptide 021, P021, or GLXC-21260 .

Key Identifiers:

• CAS Number: 1246751-68-7 

• Molecular Formula: C27H42N6O8 

• Molecular Weight: ~578.7 g/mol 

• Synonyms: P021, Peptide 021, CNTF-derived peptide, Ac-DGGLAG-NH2

• Purity: ≥99% verified by HPLC 

Mechanism of Action in Research

P21 exerts its neurotrophic effects through multiple mechanisms that make it valuable for neuroscience research:

CNTF Mimetic Activity

P21 is designed to mimic the neurotrophic properties of ciliary neurotrophic factor while possessing improved pharmacokinetic characteristics, including blood-brain barrier permeability . The peptide incorporates an adamantane moiety that blocks carboxypeptidase activity, stabilizing the peptide in vivo, while its lipophilic nature facilitates central nervous system penetration .

Neurogenesis Enhancement

In biochemical and cellular research systems, P21 promotes neurogenesis, particularly in the dentate gyrus region of the hippocampus . Experimental studies examine its effects on neural progenitor cell proliferation, synaptic plasticity, and cognitive function across various model systems.

Blood-Brain Barrier Permeability

The peptide’s ability to cross the blood-brain barrier makes it particularly valuable for central nervous system research applications . This property distinguishes it from many other neurotrophic compounds that face delivery limitations.

Scientific Research Applications

P21 has been extensively studied in peer-reviewed research, with notable publications supporting its relevance:

Alzheimer’s Disease Research

In the 3xTg-AD mouse model of Alzheimer’s disease, chronic oral P21 treatment initiated early prevented neurodegeneration, reduced Aβ and tau pathologies, and rescued episodic memory impairment . Key findings include:

• Prevention of neurodegeneration with significant reduction in tau hyperphosphorylation at major AD-associated sites

• Decreased soluble Aβ levels

• Rescued episodic memory impairment and reduced mortality rate

Hippocampal Neurogenesis & Synaptic Plasticity

Research demonstrates that P21 significantly enhances synaptic plasticity and promotes cognitive function in hippocampal models . Studies show increased expression of synaptic markers synaptophysin and synapsin I in the hippocampal dentate gyrus, supporting the maintenance of healthy neuronal networks .

Developmental & Cognitive Research

Prenatal to early postnatal P21 treatment has been shown to rescue developmental delay in Ts65Dn mouse pups, a model of Down syndrome . Treated animals exhibited normalized developmental milestones and rescued hippocampus-dependent memory impairments in adulthood.

Neurotrophic Signaling Studies

P21 is used as a molecular probe for investigating neurotrophic factor signalling pathways, particularly CNTF signaling, in controlled laboratory systems .

Why Choose Liaocheng Yixin Company?

When sourcing p21 5mg for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards and advanced solid-phase synthesis capabilities.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. P21 is available with a verified purity of ≥99% by HPLC, with Certificates of Analysis available upon request .

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• Appearance: White to off-white lyophilized powder 

• Solubility: Soluble in sterile water and buffered aqueous solutions 

• Storage: Store powder at -20°C in a sealed container, protected from light and moisture 

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification (≥99%)

4. Mass Spectrometry for molecular weight confirmation

5. Packaged in sterile, light-protected conditions for research use

When you need premium p21 5mg for research for your neurodegenerative disease, neurogenesis, or cognitive function studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.