Melanotan 1 (10mg) – Premium Research Peptide for Melanocortin Studies

Welcome to Liaocheng Yixin Company, your trusted source for premium melanotan 1 10mg for research. As a specialized peptide synthesis manufacturer operating from our facility in Shandong Province, China, we provide high-quality research compounds for the global scientific community.

Melanotan 1, also known as afamelanotide, is a synthetic 13-amino acid linear peptide analog of alpha-melanocyte stimulating hormone (α-MSH) . First synthesized at the University of Arizona in the 1980s, it was developed to investigate the effects of melanocortin receptor activation on pigmentation and photoprotection . Our melanotan 1 10mg for research offers investigators a reliable, high-purity tool for studies on melanocortin receptor 1 (MC1R) agonism, melanin synthesis, and photoprotective mechanisms.

What is Melanotan 1?

Melanotan 1 ([Nle4-D-Phe7]-α-MSH) is a linear 13-amino acid peptide distinguished from endogenous α-MSH by the substitution of norleucine for methionine at position 4 and D-phenylalanine for L-phenylalanine at position 7 . These modifications enhance the peptide’s metabolic stability and potency by increasing resistance to enzymatic degradation . Melanotan 1 is the active pharmaceutical ingredient in Scenesse®, approved by the FDA and EMA for adults with erythropoietic protoporphyria (EPP), a rare photosensitivity disorder .

Key Identifiers:

• CAS Number: 75921-69-6 

• Molecular Formula: C₇₈H₁₁₁N₂₁O₁₉ 

• Molecular Weight: ~1,646.9 g/mol 

• Sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂ 

• Synonyms: Afamelanotide, MT-1, [Nle4-D-Phe7]-α-MSH

• Purity: ≥98% verified by HPLC 

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Mechanism of Action in Research

Melanotan 1 functions as a highly selective agonist at melanocortin receptors, with a primary focus on MC1R .

MC1R Receptor Agonism
Melanotan 1 binds with high affinity to the melanocortin 1 receptor (MC1R) on melanocytes . This binding activates the cAMP signaling pathway, leading to the expression of microphthalmia transcription factor (MITF) and inducing the synthesis of eumelanin, a photoprotective form of melanin .

Melanin Synthesis & Eumelanin Induction
The increase in pigmentation induced by Melanotan 1 consists especially of increased eumelanin levels . Eumelanin provides greater cellular protection than pheomelanin, making this peptide a valuable research tool for studying photoprotective mechanisms .

Enhanced Stability
The incorporation of unnatural amino acids in Melanotan 1 contributes to improved metabolic stability compared to endogenous α-MSH . This makes it a robust model compound for studying peptide stability and degradation pathways under various stress conditions .

Scientific Research Applications

Melanotan 1 is a well-established research tool with documented applications across multiple domains:

Melanocortin Receptor Signaling Studies
Melanotan 1 serves as a positive control in cell culture assays for MC1R-related signaling and is used to study cyclic AMP, MITF expression, and melanin production in melanocytes and artificial skin models.

Photoprotection & Skin Research
MT-1 is investigated in photodermatology for its ability to increase eumelanin synthesis without UV exposure . In preclinical models, MT-1 has been studied as a possible skin cancer chemopreventive molecule, enhancing the skin’s natural protective pigment . Research has also explored its potential in conditions like vitiligo and actinic keratosis, though primary investigational focus has been on photoprotection .

Peptide Stability & Degradation Studies
MT-1 is used to investigate peptide stability under acidic, basic, neutral, oxidative, and photolytic stress conditions . Studies have identified degradation pathways including truncation, methylation, deacetylation, and oxidation . Forced degradation studies guide formulation development and shelf-life estimation .

Drug Formulation & Delivery Research
MT-1 is used to study transdermal peptide delivery and the design of sustained-release formulations such as implants and nanoparticles.

Distinction Between Melanotan 1 and Melanotan 2

Melanotan 1 and Melanotan 2 differ in structure, receptor selectivity, and research applications:

Melanotan 1 is known for its more selective photoprotective profile, whereas Melanotan 2 was found to have additional effects on MC3R and MC4R .

Why Choose Liaocheng Yixin Company?

When sourcing melanotan 1 10mg for research, quality and reliability are paramount. Here’s why researchers trust us:

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. Our Melanotan 1 meets ≥98% purity standards . Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥98% verified by HPLC 

• Appearance: White to off-white lyophilized powder 

• Solubility: Reconstitute in sterile 1% acetic acid at ≥100 µg/ml; dilute further in aqueous solutions 

• Storage: Store powder desiccated below -18°C; reconstituted product stable at 4°C for 2-7 days; avoid freeze-thaw cycles 

• melanotan 1 10mg for research

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis 

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification (≥98%) 

4. Mass Spectrometry for molecular weight confirmation 

5. Packaged in sterile conditions for research use

6. melanotan 1 10mg for research

When you need premium melanotan 1 10mg for research for your melanocortin receptor, pigmentation, or photoprotection studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.