Ipamorelin (5mg) – Premium Selective GH Secretagogue for Research

Welcome to Liaocheng Yixin Company, your trusted source for premium ipamorelin 5mg peptide for research. As a specialized peptide synthesis manufacturer operating from our facility at No. 9 Lushan Road, Dongcheng Street, Liaocheng Economic and Technological Development Zone, Shandong Province, we provide high-quality research compounds for the global scientific community.

ipamorelin 5mg peptide for research

Ipamorelin is a synthetic pentapeptide growth hormone secretagogue (GHS) and a selective agonist of the growth hormone secretagogue receptor 1a (GHS-R1a). First characterized in 1998 by Raun and colleagues, it was designed specifically to stimulate growth hormone release with minimal off-target hormonal effects. Our ipamorelin 5mg peptide for research offers investigators a reliable, high-purity compound for endocrine signaling, receptor pharmacology, and growth hormone axis studies.

What is Ipamorelin?

Ipamorelin is a pentapeptide with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2. It is classified as a selective growth hormone secretagogue that mimics the action of the natural hormone ghrelin at the GHS-R1a receptor.

Key identifiers:

• CAS Number: 170851-70-4

• Synonyms: NNC 26-0161

• Class: Pentapeptide Growth Hormone Secretagogue (GHS)

• Target Receptor: GHS-R1a (ghrelin receptor)

• Purity: ≥99% verified by HPLC

Mechanism of Action in Research

Receptor Binding and Signaling

Ipamorelin binds to the GHS-R1a receptor (Ki = 63.4 nM) in the hypothalamus and anterior pituitary. Upon binding, it activates signaling cascades that induce inositol-1,4,5-triphosphate (IP3) accumulation (EC50 = 46.9 nM) and stimulate GH release from primary rat pituitary cells (EC50 = 1.3 nM).

Selective GH Release

Ipamorelin is characterized by its high selectivity for the GH pathway. Unlike other growth hormone secretagogues such as GHRP-2 or GHRP-6, ipamorelin produces minimal elevation of cortisol, prolactin, and ACTH. Studies in pigs showed that even at doses of 420 nmol/kg, ipamorelin did not significantly increase plasma levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, or thyroid-stimulating hormone (TSH).

Ghrelin Mimicry

Ipamorelin mimics the action of ghrelin, the endogenous “hunger hormone,” but with a more targeted profile. By activating the ghrelin receptor, it stimulates pulsatile GH release that more closely mimics natural physiological patterns compared to direct GH administration.

ipamorelin 5mg peptide for research

Scientific Research Applications

Endocrine Signaling Studies

Ipamorelin serves as a valuable research tool for investigating the hypothalamic-pituitary axis and GH secretion pathways. Its selective nature allows researchers to isolate GH signaling from confounding cortisol and prolactin effects.

Receptor Pharmacology

As a selective GHS-R1a agonist, ipamorelin is used to study receptor binding, signaling pathways, and receptor regulation.

Gastrointestinal Motility Research

Studies have demonstrated that ipamorelin increases gastric emptying in rat models of postoperative ileus at doses of 0.014 or 0.14 µmol/kg. This application stems from the presence of GHS-R1a receptors in the gastrointestinal tract.

Growth and Bone Research

Research in rats (18-450 µg/animal) has shown that ipamorelin increases body weight and promotes longitudinal bone growth.

Why Choose Liaocheng Yixin Company?

When sourcing ipamorelin 5mg peptide for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. Independent testing confirms purity levels of 99.70% or higher. Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• Appearance: White lyophilized powder

• Storage: Store powder at -20°C in a sealed, desiccated container, protected from light and moisture

• Form: Lyophilized powder for research use

• ipamorelin 5mg peptide for research

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. Packaged in sterile conditions for research use

6. ipamorelin 5mg peptide for research

: How does ipamorelin compare to GHRP-2 and GHRP-6?

A: The key difference is selectivity. Ipamorelin is designed to stimulate GH with minimal effect on cortisol and prolactin, making it the “cleaner” option. GHRP-2 and GHRP-6 are more potent GH releasers but also raise cortisol, prolactin, and appetite.

: What is the selectivity profile of ipamorelin?

A: Ipamorelin selectively binds to GHS-R1a receptors to stimulate GH release without significantly affecting ACTH, cortisol, or prolactin levels. This makes it valuable for research designs requiring isolation of the GH response.

: What are the key research applications for ipamorelin?

A: Ipamorelin is used in endocrine signaling studies, receptor pharmacology, gastrointestinal motility research, and growth and bone studies.

: What purity level can I expect?

A: All batches are tested to ensure ≥99% purity by HPLC analysis. Certificates of Analysis are available upon request. Testing data shows purity levels of 99.70% or higher.

: Is this product for human use?

A: No. Our ipamorelin is manufactured strictly for research use only (RUO). It is not intended for human consumption or clinical applications.

When you need premium ipamorelin 5mg peptide for research for your endocrine, receptor pharmacology, or growth hormone axis studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust. ipamorelin 5mg peptide for research