Kisspeptin-10 (10mg) – Premium Research Peptide for Reproductive & Cancer Studies

Welcome to Liaocheng Yixin Company, your trusted source for premium kisspeptin-10 10mg peptide for research. As a specialized peptide synthesis manufacturer operating from our facility at No. 9 Lushan Road, Dongcheng Street, Liaocheng Economic and Technological Development Zone, Shandong Province, we provide high-quality research compounds for the global scientific community.

Kisspeptin-10 (Kp-10) is the C-terminal decapeptide amide of kisspeptin and the endogenous ligand for the G protein-coupled receptor GPR54 (also known as KISS1R). Among the naturally occurring kisspeptin fragments, Kp-10 contains the basic residues required to retain full functional activity and exhibits higher receptor affinity and biopotency than its longer counterparts . Our kisspeptin-10 10mg peptide for research offers investigators a reliable, high-purity compound for reproductive endocrinology, oncology, and metabolic research.kisspeptin-10 10mg peptide for research

What is Kisspeptin-10?

Kisspeptin-10 is a decapeptide derived from the KISS1 gene product. It plays a central role as a master regulator of the hypothalamic-pituitary-gonadal (HPG) axis and has been studied for its role in tumor metastasis suppression .

Key identifiers:

• CAS Number: 374675-21-5 

• Molecular Formula: C₆₃H₈₃N₁₇O₁₄ 

• Molecular Weight: ~1302.4 g/mol 

• Synonyms: Kp-10, Metastin, Kisspeptin (45-54)

• Purity: ≥99% verified by HPLC

• kisspeptin-10 10mg peptide for research

Mechanism of Action in Research

Kisspeptin-10 exerts its biological effects through activation of the GPR54 (KISS1R) receptor, a member of the G protein-coupled receptor (GPCR) family . The peptide is known to exhibit a helicoidal structure between residues Asn4 and Tyr10, with mixed α- and 310-helix characteristics, which is critical for its receptor binding and agonist activity .

Key signaling pathways:

• Activation of GPR54 stimulates phosphatidylinositol 4,5-bisphosphate hydrolysis, calcium mobilization, and ERK1/2 MAPK phosphorylation 

• Neuroendocrine regulation – modulates the hypothalamic-pituitary-gonadal axis by stimulating gonadotropin-releasing hormone (GnRH) secretion 

• Structure-activity relationships – in vitro assays show that specific Ala substitutions, such as at positions 6 or 10 of Kp-10, result in a significant increase in EC₅₀ values, highlighting the critical role of these residues for receptor agonistic activity 

Scientific Research Applications

Kisspeptin-10 has been extensively studied across multiple research domains:

Reproductive Endocrinology

Kp-10 is a cornerstone of reproductive research. It has been shown to stimulate GnRH and gonadotropin secretion, functioning as the “master switch” for puberty and fertility . Recent studies in stress models demonstrated that Kp-10 administration increases levels of gonadotropin-releasing hormone, kisspeptin, and the kisspeptin receptor in the brain. Intranasal administration in male rat models of post-traumatic stress disorder exerted a central effect independent of sex steroids, indicating therapeutic potential for stress-induced reproductive dysfunction .

Ovulation Research

A study on rabbit models evaluated the ovulatory effect of Kp-10. At a dose of 250 μg, Kp-10 induced ovulation in 87.5% of does, matching the response of the GnRH analog gonadorelin. Histological analysis confirmed that Kp-10 promoted preovulatory follicle development and corpus luteum formation, with enhanced angiogenesis indicated by increased vascular endothelial growth factor (VEGF) expression .

Metabolic Research

Recent research explored Kp-10’s potential in gestational diabetes mellitus (GDM) models. GPR54 expression was found to be significantly downregulated in placental tissues of GDM rats. Kp-10 treatment improved fasting blood glucose, insulin sensitivity, and fetal outcomes by restoring the cAMP/protein kinase A (PKA) signaling pathway and enhancing glucose uptake through upregulation of Glut-4, Insr, and Irs1 expression .

Oncology Research

Kp-10 has demonstrated anti-metastatic and pro-apoptotic effects in cancer research models:

• Metastasis suppression – Kp-10 inhibits bone-directed migration of GPR54-positive breast cancer cells in vitro, with a significant dose-window effect observed at concentrations of 10⁻⁹ M to 10⁻¹¹ M. This anti-migratory action appears to involve the SDF-1/CXCR4 signaling pathway .

• Triple-negative breast cancer – Exogenous Kp-10 treatment reduced cell viability and migration, induced a dose-dependent upregulation of KISS1 mRNA, and promoted apoptosis through upregulation of CASP3, CASP8, CASP9, and BAX while suppressing BCL2, suggesting activation of both apoptotic pathways .

Why Choose Liaocheng Yixin Company?

When sourcing kisspeptin-10 10mg peptide for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• Appearance: White lyophilized powder

• Storage: Store powder at -20°C in a sealed container, protected from light and moisture

• Form: Lyophilized powder for research use

• kisspeptin-10 10mg peptide for research

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. Packaged in sterile conditions for research use

6. kisspeptin-10 10mg peptide for research

: What is Kisspeptin-10 and how does it work in research?
A: Kisspeptin-10 is the endogenous ligand for the GPR54 (KISS1R) receptor and plays a master regulatory role in the hypothalamic-pituitary-gonadal axis. It stimulates GnRH secretion and has been studied for its anti-metastatic and pro-apoptotic properties in cancer research .

: What are the key research applications for Kp-10?
A: Kp-10 is used in reproductive endocrinology (fertility regulation, ovulation induction), oncology (metastasis suppression, apoptosis induction), and metabolic research (insulin signaling, gestational diabetes) .

: What receptor does Kp-10 target?
A: Kp-10 is the endogenous ligand for GPR54 (also known as KISS1R, KiSS-1 receptor, or hOT7T175), a G protein-coupled receptor that activates calcium mobilization and ERK1/2 MAPK phosphorylation pathways .

kisspeptin-10 10mg peptide for research

: What purity level can I expect?
A: All batches are tested to ensure ≥99% purity by HPLC analysis. Certificates of Analysis are available upon request.

: Is this product for human use?
A: No. Our Kisspeptin-10 is manufactured strictly for research use only (RUO). It is not intended for human consumption or clinical applications.

When you need premium kisspeptin-10 10mg peptide for research for your reproductive endocrinology, oncology, or metabolic studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.