Humanin (10mg) – Premium Mitochondrial Peptide for Research

Welcome to Liaocheng Yixin Company, your trusted source for premium humanin 10mg peptide for research. As a specialized peptide synthesis manufacturer operating from our facility at No. 9 Lushan Road, Dongcheng Street, Liaocheng Economic and Technological Development Zone, Shandong Province, we provide high-quality research compounds for the global scientific community.

Humanin is a 24-amino acid mitochondrial-derived peptide (MDP) first discovered in the early 2000s as a neuroprotective factor that rescues neuronal cells from Alzheimer’s disease-associated insults . It is encoded by mitochondrial DNA and has since been shown to exert broad cytoprotective effects across various experimental models, including neurodegenerative disorders, cardiovascular diseases, metabolic disorders, and age-related conditions . Our humanin 10mg peptide for research offers investigators a reliable, high-purity compound for neuroprotection, apoptosis, and metabolic research. humanin 10mg peptide for research

What is Humanin?

Humanin is a naturally occurring mitochondrial peptide consisting of 24 amino acids with the sequence MAPRGFSCLLLLTSEIDLPVKRRA, and a molecular weight of approximately 2687 Da . It is characterized by three distinct regions: a polar C-terminal (PVKRRA), a positively charged N-terminal (MAPR), and a central hydrophobic region (GFSCLLLLTSEIDL) . Humanin is also known by the CAS number 330936-69-1 .

Key identifiers:

• CAS Number: 330936-69-1 

• Molecular Formula: C₁₁₉H₂₀₄N₃₄O₃₂S₂ 

• Molecular Weight: ~2687.23 g/mol 

• Sequence: MAPRGFSCLLLLTSEIDLPVKRRA (24 amino acids) 

• Synonyms: HN, Mitochondrial-derived peptide

• Purity: ≥99% verified by HPLC

• humanin 10mg peptide for research

Mechanism of Action in Research

Humanin exerts its effects through multiple well-characterized mechanisms:

Anti-Apoptotic Activity

Humanin binds to and inhibits pro-apoptotic proteins, particularly Bax (a proapoptotic member of the Bcl-2 family), preventing mitochondrial-mediated apoptosis . Through this interaction, it blocks Bax-induced cell death and inhibits the transition from its active conformation . Humanin also binds and inhibits BimEL, another pro-apoptotic Bcl-2 family member .

Neuroprotective Signaling

Humanin protects neurons from the toxic effects of amyloid-beta (Aβ) peptides and familial Alzheimer’s disease-causing gene mutations . It activates cellular signaling cascades that intervene in c-Jun N-terminal kinase (JNK) activation and improves hippocampal acetylcholine levels while attenuating oxidative stress and associated neurotoxicity .

Autophagy Induction

Recent research has identified Humanin as an autophagy inducer that promotes cell survival under metabolic and oxidative stress conditions . This function is particularly significant for research into metabolic disorders and conditions involving impaired autophagy.

Receptor-Mediated Signaling

Humanin acts through cell surface receptors, including CNTFR, WSX-1, and gp130, which activate the STAT3 signaling pathway . This pathway contributes to increased cell survival, particularly in pancreatic beta cells.

humanin 10mg peptide for research

Scientific Research Applications

Humanin has been extensively studied across multiple research domains:

Neurodegenerative Disease Research

Humanin is a cornerstone of Alzheimer’s disease research, demonstrating neuroprotective effects against amyloid-beta toxicity in both neuronal and cerebrovascular smooth muscle cells . Research shows that aging reduces brain expression of Humanin, leading to cognitive impairment and elevating neurodegeneration risk . The analog HNG (Ser¹⁴→Gly) exhibits 1000-fold greater neuroprotective potency than native Humanin .

Metabolic Disorder Research

Humanin improves systemic insulin sensitivity and enhances glucose uptake in skeletal muscle . Research has identified Humanin as a more influential biomarker than traditional markers in T2DM risk prediction . Studies have also evaluated Humanin’s role in regulating autophagy pathways in metabolic diseases .

Cardiovascular Research

Humanin demonstrates protective effects in cardiac myoblasts, decreasing oxidative stress and preserving mitochondrial integrity . It exhibits broad-spectrum activity on pancreas, brain, testis, and heart tissues .

Cancer Research

Humanin acts as a pro-survival factor in certain tumor cell lines, including KGN cells, where it decreases apoptosis . It has been investigated as a potential biomarker for prostate disease risk stratification .

Aging and Longevity Research

Humanin levels are associated with increased lifespan in aged rat models, and its longevity effects extend to a range of biological activities including anti-apoptosis and oxidative stress protection across multiple organs . Research suggests Humanin may promote healthy aging and maintain mitochondrial function .

Why Choose Liaocheng Yixin Company?

When sourcing humanin 10mg peptide for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC analysis. Our Humanin meets ≥99% purity standards. Certificates of Analysis are available upon request.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• Appearance: White to off-white lyophilized powder 

• Solubility: Formic acid: 1 mg/ml ; soluble in DMSO and other organic solvents

• Storage: Store powder at -20°C in a sealed, desiccated container, protected from light 

• Form: Lyophilized powder for research use

• humanin 10mg peptide for research

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. Packaged in sterile conditions for research use

6. humanin 10mg peptide for research

: What is Humanin and how does it work in research?

A: Humanin is a 24-amino acid mitochondrial-derived peptide (MDP) with neuroprotective and anti-apoptotic properties . It binds to and inhibits pro-apoptotic proteins such as Bax and BimEL, preventing mitochondrial-mediated apoptosis, and activates protective signaling pathways including STAT3 .

: What makes the HNG analog of Humanin significant in research?

A: HNG (Humanin-Glycine) is a synthetic analog where the serine at position 14 is replaced with glycine. It exhibits approximately 1000-fold greater neuroprotective potency than native Humanin and is the most widely studied analog in both in vivo and in vitro disease models .

: What research applications use Humanin?humanin 10mg peptide for research

A: Humanin is used in neurodegenerative disease research (Alzheimer’s, Parkinson’s), metabolic disorder studies (diabetes, insulin sensitivity), cardiovascular research, cancer research, apoptosis studies, and aging/longevity research .

: What purity level can I expect?

A: All batches are tested to ensure ≥99% purity by HPLC analysis. Certificates of Analysis are available upon request.

: Is this product for human use?

A: No. Our Humanin is manufactured strictly for research use only (RUO). It is not intended for human consumption or clinical applications .

When you need premium humanin 10mg peptide for research for your neurodegenerative, metabolic, or apoptosis studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust.