Pentapeptide-18 (Leuphasyl) (200mg) – Premium Enkephalin-Mimetic Peptide for Research

 

Welcome to Liaocheng Yixin Company, your trusted source for premium pentapeptide-18 leuphasyl 200mg for research. As a specialized peptide synthesis manufacturer operating from our facility in Shandong Province, China, we provide high-quality research compounds for the global scientific community. pentapeptide-18 leuphasyl 200mg for research

Pentapeptide-18 (Leuphasyl®) is a synthetic pentapeptide with the sequence Tyr-D-Ala-Gly-Phe-Leu that functions as a δ-opioid receptor agonist, mimicking the action of natural enkephalins . It is also known commercially as Leuphasyl, a name derived from its leucine content and enkephalin-mimicking properties . This peptide offers a distinct research tool for studying G-protein-coupled receptor signaling, neuromuscular communication, and cellular aging pathways . Our pentapeptide-18 leuphasyl 200mg for research provides a reliable, high-purity compound for advanced dermatological, neuropharmacological, and receptor biology studies.

What is Pentapeptide-18 (Leuphasyl)?

Pentapeptide-18 is a synthetic analog of endogenous enkephalins, designed to resist enzymatic degradation and provide a stable probe for studying opioid receptor pathways. The substitution of glycine at position 2 with D-alanine enhances its stability against proteolytic cleavage . This structural modification makes it significantly more resistant to degradation than native leucine-enkephalin, a key feature for prolonged signaling studies .pentapeptide-18 leuphasyl 200mg for research

Key identifiers:

• CAS Number: 64963-01-5

• Molecular Formula: C29H39N5O7 

• Molecular Weight: 569.65 g/mol 

• Sequence: H-Tyr-D-Ala-Gly-Phe-Leu-OH (YdAGFL)

• Synonyms: Leuphasyl, Pentapeptide-18, Leu-enkephalin analog

• Purity: ≥99% verified by HPLC

• pentapeptide-18 leuphasyl 200mg for research

Mechanism of Action in Research

Pentapeptide-18 operates through a well-characterized mechanism centered on opioid receptor modulation, offering avenues for research into neuromuscular regulation and anti-aging pathways.

Enkephalin Receptor Agonism

Pentapeptide-18 binds to δ-opioid receptors (enkephalin receptors), which are G-protein-coupled receptors (GPCRs) located on the presynaptic membrane of neurons . Upon binding, it initiates a signaling cascade that activates inhibitory G-proteins (Gi/o), leading to the inhibition of voltage-gated calcium channels . This process reduces the influx of calcium into the presynaptic terminal, thereby decreasing the release of the neurotransmitter acetylcholine (ACh) into the synaptic cleft, resulting in a reduction in the frequency and intensity of muscle contractions .

Neuromodulation and Calcium Signaling

By influencing calcium-dependent pathways involved in muscle contraction, Pentapeptide-18 helps modulate neuronal signaling and reduces neurotransmitter release without the complete paralysis associated with botulinum toxin . The peptide is often described as providing a “subtle relaxation mechanism” that avoids a “frozen” appearance, making it ideal for research on delicate tissues . This mechanism is complementary to other “Botox-like” peptides like Argireline (Acetyl Hexapeptide-8), which targets a different stage of the neuromuscular signaling cascade (SNARE complex) .pentapeptide-18 leuphasyl 200mg for research

Anti-Aging Pathway Interactions

Recent 2026 research has revealed that Pentapeptide-18 is not limited to neuromodulatory effects; it also possesses biophysical properties capable of influencing cellular aging processes at the molecular level. Molecular docking and dynamics studies have demonstrated stable binding to key signaling proteins implicated in skin aging, including TGF-β receptor-I, TNF-α, MAPK14, and PI3K/AKT, which collectively regulate inflammatory responses, oxidative stress, and extracellular matrix (ECM) remodeling .

Scientific Research Applications

Pentapeptide-18 has been studied across multiple research domains, with 2026 publications reinforcing its multi-target profile.

Receptor and GPCR Pharmacology

• Studying δ-opioid receptor binding kinetics, downstream signaling pathways (Gi protein activation, calcium channel modulation), and structure-activity relationships 

• Utilized as a stable research probe and comparator for investigating enkephalin receptor pharmacology in dermal and neuronal model systems 

Dermatological and Cutaneous Signaling Research

• Investigating mechanisms of expression line formation and neuromuscular communication in skin models 

• Recent in silico studies (Akhan et al., 2026) have demonstrated interactions with MAPK, TNF-α, and NF-κB pathways, suggesting applications in skin inflammation and ECM remodeling research 

• In 2025, Pentapeptide-18 passed cosmetic ingredient registration in China (NMPA备案号 20250152), with an approved safe use level up to 1.86% in cosmetic products, making it a reference standard in regulatory research pentapeptide-18 leuphasyl 200mg for research

Melanogenesis and Pigmentation Research

• Research has explored Pentapeptide-18 derivatives containing D-tyrosine for studying melanin synthesis inhibition and tyrosinase activity in melanoma cell models 

Synergy and Formulation Studies

• Widely used in experimental formulations for studying synergistic effects with other neurotransmitter-inhibiting peptides like Argireline, targeting different stages of neuromuscular signaling 

Why Choose Liaocheng Yixin Company?

When sourcing pentapeptide-18 leuphasyl 200mg for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards and follows standard protocols for solid-phase peptide synthesis (SPPS) .

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC and mass spectrometry. Certificates of Analysis confirming purity exceeding 99% are available upon request .

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• Sequence: H-Tyr-D-Ala-Gly-Phe-Leu-OH (YdAGFL)

• Molecular Weight: 569.65 g/mol

• Appearance: White to off-white lyophilized powder

• Storage: Store powder at -20°C in a sealed, desiccated container, protected from light and moisture. Avoid moisture exposure .

• Form: Lyophilized powder for research use

• pentapeptide-18 leuphasyl 200mg for research

Quality Assurance 

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis (SPPS)

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. Packaged under desiccated, sterile conditions for research use

6. pentapeptide-18 leuphasyl 200mg for research

: What is Pentapeptide-18 (Leuphasyl) and how does it work in research?

A: Pentapeptide-18 (Leuphasyl) is a synthetic pentapeptide that acts as a δ-opioid receptor agonist, mimicking the body’s own enkephalin system . Its primary research mechanism involves binding to opioid receptors on presynaptic neurons, activating inhibitory G-proteins, and reducing calcium influx, which leads to decreased acetylcholine release and modulation of muscle contractions . Recent research has also demonstrated its potential to interact with key aging-related signaling proteins like TGF-β and MAPK .

: What are the key research applications for Pentapeptide-18?

A: Pentapeptide-18 is used in receptor pharmacology (studying opioid receptor signaling), dermatological and cutaneous research (expression lines, aging pathways), melanogenesis studies, and formulation synergy research with other neurotransmitter-inhibiting peptides .

: How does Pentapeptide-18 differ from other “Botox-like” peptides?

A: Its mechanism is distinct from Argireline (Acetyl Hexapeptide-8) and SNAP-8. Pentapeptide-18 acts as an enkephalin receptor agonist, inhibiting acetylcholine release via G-protein-coupled signaling, while Argireline/SNAP-8 block SNARE complex assembly . This mechanistic difference is the basis for their synergistic effect when combined in research. pentapeptide-18 leuphasyl 200mg for research

: What purity level can I expect?

A: All batches are tested to ensure ≥99% purity by HPLC analysis. Certificates of Analysis are available upon request .

: Is this product for human use?

A: No. Our Pentapeptide-18 is manufactured strictly for research use only (RUO). It is not intended for human consumption, injection, or clinical applications.

When you need premium pentapeptide-18 leuphasyl 200mg for research for your receptor pharmacology, dermatological, or cellular signaling studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust. pentapeptide-18 leuphasyl 200mg for research