Pinealon (20mg) – Premium Neuroprotective Tripeptide for Research

Welcome to Liaocheng Yixin Company, your trusted source for premium pinealon 20mg peptide for research. As a specialized peptide synthesis manufacturer operating from our facility in Shandong Province, China, we provide high-quality research compounds for the global scientific community.

Pinealon is a synthetic tripeptide composed of glutamic acid, aspartic acid, and arginine (Glu-Asp-Arg or EDR). Developed within the St. Petersburg Institute of Bioregulation and Gerontology, it sits at the intersection of neuroprotection, cognitive enhancement, and the biology of the pineal gland—a small brain structure that regulates circadian timing through melatonin production. Unlike many peptides that interact with cell surface receptors, Pinealon’s small size is believed to allow it to cross cellular and nuclear membranes to interact directly with DNA, thereby modulating gene expression. Our pinealon 20mg peptide for research offers investigators a reliable, high-purity compound for advanced neurobiology, gerontology, and circadian rhythm studies.  pinealon 20mg peptide for research

What is Pinealon?

Pinealon is a synthetic tripeptide with the sequence Glu-Asp-Arg (EDR). It belongs to a class of short regulatory peptides derived from tissue-specific proteins that represent an underexplored area in the biology of aging. Research indicates that Pinealon operates through a combination of antioxidant activity and direct genomic interaction, making it a uniquely versatile probe for cellular and cognitive studies. pinealon 20mg peptide for research

Key identifiers:

• Sequence: Glu-Asp-Arg (EDR)

• Molecular Formula: C₁₅H₂₅N₇O₈

• Molecular Weight: 418.41 g/mol

• Purity: ≥99% verified by HPLC

•  pinealon 20mg peptide for research

Mechanism of Action in Research

Pinealon’s research appeal is rooted in its dual mechanism of action, offering a unique window into neuroprotection and gene regulation.

• Antioxidant and Neuroprotective Activity: Pinealon demonstrates a dose-dependent restriction of reactive oxygen species (ROS) accumulation in cerebellar granule cells, neutrophils, and PC12 cells induced by oxidative stress. This protective effect is accompanied by a delayed time course of ERK 1/2 activation and modification of the cell cycle. The restriction of ROS accumulation and cell mortality saturates at lower concentrations, whereas cell cycle modulation continues at higher concentrations, suggesting that beyond its antioxidant activity, Pinealon can interact directly with the cell genome.

• Genomic Interaction and Gene Expression: Pinealon is believed to cross cellular and nuclear membranes to interact directly with DNA, thereby modulating gene expression. This mechanism is proposed to restore youthful gene expression patterns in ageing neurons.  pinealon 20mg peptide for research

• Cognitive and Behavioral Effects: Research on rhesus monkeys demonstrated that a 10-day course of Pinealon significantly reduced training duration, reduced motor reaction time when choosing stimuli, and improved selective attention. The study noted enhanced connections between the frontal-temporal-parietal structures responsible for cognitive properties. It has also been shown to improve spatial orientation and learning ability in rat models.  pinealon 20mg peptide for research

Scientific Research Applications

• Neuroprotection and Oxidative Stress Research: Pinealon is a valuable tool for studying the cellular mechanisms of neuroprotection, particularly the interplay between oxidative stress, apoptosis, and the MAPK/ERK signaling pathway.

• Cognitive Enhancement and Aging: It is investigated for its ability to improve cognitive function, spatial orientation, learning, and attention in models of ageing and cognitive decline, including in primate studies.

• Circadian Rhythm and Pineal Gland Biology: Pinealon is studied for its potential influence on the pineal gland and the modulation of circadian rhythms, offering a molecular probe into the connection between circadian timing and aging.

Important Research Considerations

Evidence Base: Pinealon has a narrower evidence base than some other peptides. Almost all of the research originates from a single research tradition—the St. Petersburg School of Bioregulatory Peptide Science—and has not been independently replicated by Western research groups. It has not been the subject of large, randomized controlled trials. The biological target is considered highly legitimate, but the evidence is primarily preclinical.

Why Choose Liaocheng Yixin Company?

When sourcing pinealon 20mg peptide for research, quality and reliability are paramount. Here’s why researchers trust us:

Manufacturer-Direct Quality

We are a legitimate, licensed peptide synthesis company with a physical headquarters in Shandong Province, China. Our facility maintains strict quality control standards.

Verified Purity Standards

Every batch undergoes rigorous testing using HPLC and mass spectrometry. Certificates of Analysis confirming purity exceeding 99% are available upon request.

Research-Grade Specifications

• Purity: ≥99% verified by HPLC

• Sequence: Glu-Asp-Arg (EDR)

• Molecular Weight: 418.41 g/mol

• Appearance: White to off-white lyophilized powder

• Storage: Store powder at -20°C in a sealed, desiccated container, protected from light and moisture

•  pinealon 20mg peptide for research

Quality Assurance & Testing

Every batch undergoes comprehensive quality control:

1. Synthesis by experienced chemists using solid-phase peptide synthesis

2. Purification via preparative HPLC

3. Analysis using HPLC for purity verification

4. Mass Spectrometry for molecular weight confirmation

5. Packaged in sterile conditions for research use

6.  pinealon 20mg peptide for research

: What is Pinealon and how does it work in research?

A: Pinealon is a synthetic tripeptide (Glu-Asp-Arg) that exhibits neuroprotective, antioxidant, and cognitive-enhancing properties. Its mechanisms include reducing oxidative stress, modulating ERK 1/2 signaling, and potentially interacting directly with the cell genome to modulate gene expression.

: What are the key research applications for Pinealon?

A: Pinealon is used in neuroprotection and oxidative stress research, cognitive enhancement studies, and circadian rhythm biology research.

: What is the evidence base for Pinealon?

A: The evidence for Pinealon is primarily preclinical, originating from a single research tradition. While its biological target is considered legitimate, it has not been independently replicated by Western research groups and lacks large, randomized clinical trial data.

: What purity level can I expect?

A: All batches are tested to ensure ≥99% purity by HPLC analysis. Certificates of Analysis are available upon request.

: Is this product for human use?

A: No. Our Pinealon is manufactured strictly for research use only (RUO). It is not intended for human consumption or clinical applications.

When you need premium pinealon 20mg peptide for research for your neurobiology, gerontology, or circadian rhythm studies, choose a manufacturer that prioritizes quality, transparency, and reliability. Liaocheng Yixin Company combines expert peptide synthesis capabilities with rigorous quality control to deliver research materials you can trust. pinealon 20mg peptide for research